CRCGN015_MCF10A.WT.HP_24H:L15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description etodolac 11.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:L15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 4.19535
SYNGAP1 synaptic Ras GTPase activating protein 1 4.17963
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.84689
SPAG4 sperm associated antigen 4 3.29656
FAM20B family with sequence similarity 20, member B 3.18181
KLHL21 kelch-like family member 21 3.13322
WFS1 Wolfram syndrome 1 (wolframin) 2.91096
CXCR4 chemokine (C-X-C motif) receptor 4 2.89037
ACAA1 acetyl-CoA acyltransferase 1 2.38117
HBA1 hemoglobin, alpha 1 2.27668
FZD7 frizzled class receptor 7 2.14925
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.06134
PRKCH protein kinase C, eta 2.04748

decreased expression

Symbol Name Standardized Value
DIPK1A divergent protein kinase domain 1A -4.03541
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.51609
CDC25B cell division cycle 25B -3.38696
NLRP4 NLR family, pyrin domain containing 4 -3.32718
HMG20B high mobility group 20B -3.32069
HSPA8 heat shock 70kDa protein 8 -3.273
DYNLT3 dynein, light chain, Tctex-type 3 -3.13702
NUP85 nucleoporin 85kDa -3.10999
CHMP4B charged multivesicular body protein 4B -3.04793
CD58 CD58 molecule -2.99375
KIF20A kinesin family member 20A -2.90429
BPHL biphenyl hydrolase-like (serine hydrolase) -2.78164
GDF15 growth differentiation factor 15 -2.67045
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.53113
TENT4A terminal nucleotidyltransferase 4A -2.42877
MTERF3 mitochondrial transcription termination factor 3 -2.23186
WDR46 WD repeat domain 46 -2.16107
BASP1 brain abundant, membrane attached signal protein 1 -2.09268