CRCGN015_MCF10A.WT.HP_24H:L20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dichlorobenzidine 32.26 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

163 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:L20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 5.79212
H2BC12 H2B clustered histone 12 5.1698
CXCL2 chemokine (C-X-C motif) ligand 2 4.90752
KCTD5 potassium channel tetramerization domain containing 5 4.24822
AGR2 anterior gradient 2 4.04943
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.91381
IL1B interleukin 1, beta 3.89478
TNIP1 TNFAIP3 interacting protein 1 3.84357
STXBP1 syntaxin binding protein 1 3.79599
CEMIP2 cell migration inducing hyaluronidase 2 3.73101
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.66507
PLEK2 pleckstrin 2 3.4533
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.44126
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.42238
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.10775
IER3 immediate early response 3 3.09439
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.7576
CNRIP1 cannabinoid receptor interacting protein 1 2.71243
CXCL3 chemokine (C-X-C motif) ligand 3 2.70594
S100A4 S100 calcium binding protein A4 2.69379
ZC3H12A zinc finger CCCH-type containing 12A 2.68332
RPP38 ribonuclease P/MRP 38kDa subunit 2.68087
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.66415
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.60157
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.59146
GRN granulin 2.58429
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.52266
H2AC19 H2A clustered histone 19 2.47326
H2BC9 H2B clustered histone 9 2.43182
FOSL1 FOS-like antigen 1 2.35253
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.33936
PLCB4 phospholipase C, beta 4 2.32549
WIF1 WNT inhibitory factor 1 2.30098
AVPI1 arginine vasopressin-induced 1 2.30041
ZC2HC1C zinc finger, C2HC-type containing 1C 2.29651
SH2D2A SH2 domain containing 2A 2.26533
CD83 CD83 molecule 2.26142
PEAK1 pseudopodium-enriched atypical kinase 1 2.24961
HS1BP3 HCLS1 binding protein 3 2.22661
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.20477
OXSR1 oxidative stress responsive 1 2.20225
SPINT2 serine peptidase inhibitor, Kunitz type, 2 2.17876
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.17344
HBEGF heparin-binding EGF-like growth factor 2.15975
LRP10 low density lipoprotein receptor-related protein 10 2.15643
FAT1 FAT atypical cadherin 1 2.14821
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.12959
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 2.12731
FPGS folylpolyglutamate synthase 2.1248
IL23A interleukin 23, alpha subunit p19 2.12001
RGS2 regulator of G-protein signaling 2 2.11926
VAT1 vesicle amine transport 1 2.10836
PRELID3A PRELI domain containing 3A 2.09544
TG thyroglobulin 2.09516
TWF2 twinfilin actin binding protein 2 2.08859
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.05312
SH2B3 SH2B adaptor protein 3 2.02939
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.02266
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.01226
VEGFC vascular endothelial growth factor C 2.00066

decreased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa -5.12374
UBE2C ubiquitin-conjugating enzyme E2C -4.51777
KIF20A kinesin family member 20A -4.23734
CDK1 cyclin-dependent kinase 1 -4.00657
MCM3 minichromosome maintenance complex component 3 -3.68685
TP53 tumor protein p53 -3.64563
COG2 component of oligomeric golgi complex 2 -3.62543
HEATR1 HEAT repeat containing 1 -3.60537
CCNB2 cyclin B2 -3.54043
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.50297
RFC2 replication factor C (activator 1) 2, 40kDa -3.43538
PRR15L proline rich 15-like -3.28149
NUSAP1 nucleolar and spindle associated protein 1 -3.2653
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.17262
HOXA5 homeobox A5 -3.04533
FKBP5 FK506 binding protein 5 -2.98409
NT5DC2 5'-nucleotidase domain containing 2 -2.92606
PSRC1 proline/serine-rich coiled-coil 1 -2.89323
CDT1 chromatin licensing and DNA replication factor 1 -2.8093
RAD51AP1 RAD51 associated protein 1 -2.74501
HADH hydroxyacyl-CoA dehydrogenase -2.70543
MSMO1 methylsterol monooxygenase 1 -2.69643
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.68391
KIF11 kinesin family member 11 -2.66081
RNF167 ring finger protein 167 -2.65743
SLC25A46 solute carrier family 25, member 46 -2.6266
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.62329
CCNF cyclin F -2.62066
GOLT1B golgi transport 1B -2.57774
CDC45 cell division cycle 45 -2.54952
ESRRG estrogen-related receptor gamma -2.5386
KIF15 kinesin family member 15 -2.53503
NCAPD2 non-SMC condensin I complex, subunit D2 -2.52106
DNM1 dynamin 1 -2.52024
FBXO5 F-box protein 5 -2.51999
PTH1R parathyroid hormone 1 receptor -2.44948
C1QBP complement component 1, q subcomponent binding protein -2.43195
UBE3C ubiquitin protein ligase E3C -2.4298
ARB2A ARB2 cotranscriptional regulator A -2.41043
ASF1B anti-silencing function 1B histone chaperone -2.40297
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.39669
TEX264 testis expressed 264 -2.38028
LYPLA1 lysophospholipase I -2.36363
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.35383
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.346
EMX2 empty spiracles homeobox 2 -2.33535
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 -2.31177
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.31074
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.30815
HJURP Holliday junction recognition protein -2.29197
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.28866
SCYL3 SCY1-like 3 (S. cerevisiae) -2.2861
AURKB aurora kinase B -2.28122
MYG1 MYG1 exonuclease -2.26937
VSIG4 V-set and immunoglobulin domain containing 4 -2.26347
TMEM176A transmembrane protein 176A -2.25183
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.25067
ING4 inhibitor of growth family, member 4 -2.23337
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.20965
RACGAP1 Rac GTPase activating protein 1 -2.2069
COA3 cytochrome c oxidase assembly factor 3 -2.20013
PLK1 polo-like kinase 1 -2.19573
CCNA2 cyclin A2 -2.18277
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 -2.16355
COQ6 coenzyme Q6 monooxygenase -2.15503
C1QA complement component 1, q subcomponent, A chain -2.15072
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.12924
IRAK1 interleukin-1 receptor-associated kinase 1 -2.12661
KIF4A kinesin family member 4A -2.12405
MMP13 matrix metallopeptidase 13 -2.11347
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.10962
UMOD uromodulin -2.10942
FOXM1 forkhead box M1 -2.10762
RBM34 RNA binding motif protein 34 -2.10151
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 -2.10095
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.1001
NLRP4 NLR family, pyrin domain containing 4 -2.09915
MCM5 minichromosome maintenance complex component 5 -2.09423
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.09183
DEPDC1 DEP domain containing 1 -2.08941
POLM polymerase (DNA directed), mu -2.087
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.08146
ZBED1 zinc finger, BED-type containing 1 -2.07503
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) -2.05971
VDAC1 voltage-dependent anion channel 1 -2.05396
CDKN3 cyclin-dependent kinase inhibitor 3 -2.04401
BARD1 BRCA1 associated RING domain 1 -2.04222
CCNC cyclin C -2.04066
CCDC102B coiled-coil domain containing 102B -2.03994
MCTS1 malignant T cell amplified sequence 1 -2.03758
CAB39 calcium binding protein 39 -2.03704
PARPBP PARP1 binding protein -2.02909
BOLA1 bolA family member 1 -2.0268
SLBP stem-loop binding protein -2.02339
NRSN2 neurensin 2 -2.02053
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.01779
CDK4 cyclin-dependent kinase 4 -2.016
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.01556
POT1 protection of telomeres 1 -2.014
GNPAT glyceronephosphate O-acyltransferase -2.01232
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.00595
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.00478
ACSM2A acyl-CoA synthetase medium-chain family member 2A -2.00445