CRCGN015_MCF10A.WT.HP_24H:L23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description carbon-tetrachloride 32.77 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:L23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.25581
KIF5C kinesin family member 5C 3.98849
TOPBP1 topoisomerase (DNA) II binding protein 1 3.84483
ACAA1 acetyl-CoA acyltransferase 1 3.14642
WIF1 WNT inhibitory factor 1 2.69443
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.29648
MELK maternal embryonic leucine zipper kinase 2.12537

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -9.65447
CDC20 cell division cycle 20 -4.81474
WASHC4 WASH complex subunit 4 -3.85349
VDAC1 voltage-dependent anion channel 1 -3.55879
PSIP1 PC4 and SFRS1 interacting protein 1 -3.12765
FOXJ3 forkhead box J3 -2.53142
PGR progesterone receptor -2.38772
P3H3 prolyl 3-hydroxylase 3 -2.35436
SZT2 seizure threshold 2 homolog (mouse) -2.35069
EXO5 exonuclease 5 -2.30417
OASL 2'-5'-oligoadenylate synthetase-like -2.22305
ARHGAP22 Rho GTPase activating protein 22 -2.20834
CLEC2D C-type lectin domain family 2, member D -2.15468
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.13959
SFRP4 secreted frizzled-related protein 4 -2.1337
MMP25 matrix metallopeptidase 25 -2.12714
SCG3 secretogranin III -2.11057
HESX1 HESX homeobox 1 -2.10038
KPNA5 karyopherin alpha 5 (importin alpha 6) -2.0709
LEFTY1 left-right determination factor 1 -2.00411