CRCGN015_MCF10A.WT.HP_24H:L24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description carbon-tetrachloride 10.92 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:L24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 4.10824
CXCL2 chemokine (C-X-C motif) ligand 2 3.49293
KIF5C kinesin family member 5C 3.46858
COQ8A coenzyme Q8A 3.36641
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.2188
E2F2 E2F transcription factor 2 3.14893
CENPE centromere protein E, 312kDa 2.99564
CCP110 centriolar coiled coil protein 110kDa 2.4787
SPAG4 sperm associated antigen 4 2.45873
ANKRD10 ankyrin repeat domain 10 2.43189
EPHB2 EPH receptor B2 2.42027
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.38573
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.35712
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.26916
PDLIM1 PDZ and LIM domain 1 2.12879
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.07347
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.05598
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.05525
AGR2 anterior gradient 2 2.00259

decreased expression

Symbol Name Standardized Value
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.89124
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.81184
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.12022
MSN moesin -2.52076
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.18008