| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | nitromethane 99.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
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116 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 5.26711 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 5.26242 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 4.99836 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.54085 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 4.24415 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 4.00164 |
| CHEK1 | checkpoint kinase 1 | 3.88656 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 3.83591 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.71552 |
| TLCD3A | TLC domain containing 3A | 3.67626 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 3.578 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 3.51509 |
| ANKRD10 | ankyrin repeat domain 10 | 3.15191 |
| ZFY | zinc finger protein, Y-linked | 3.14546 |
| KDM5D | lysine (K)-specific demethylase 5D | 3.01773 |
| IGHMBP2 | immunoglobulin mu binding protein 2 | 2.86522 |
| TASOR2 | transcription activation suppressor family member 2 | 2.82601 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 2.64244 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 2.61838 |
| WIF1 | WNT inhibitory factor 1 | 2.52226 |
| PTK2 | protein tyrosine kinase 2 | 2.46561 |
| MIS18BP1 | MIS18 binding protein 1 | 2.40031 |
| GAB2 | GRB2-associated binding protein 2 | 2.39365 |
| MCM10 | minichromosome maintenance complex component 10 | 2.3802 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 2.34164 |
| NAPG | N-ethylmaleimide-sensitive factor attachment protein, gamma | 2.28091 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 2.27623 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 2.24488 |
| CCSER2 | coiled-coil serine-rich protein 2 | 2.22449 |
| SLC25A32 | solute carrier family 25 (mitochondrial folate carrier), member 32 | 2.22024 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 2.20789 |
| UIMC1 | ubiquitin interaction motif containing 1 | 2.20033 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 2.18315 |
| TRMO | tRNA methyltransferase O | 2.16224 |
| ZNF23 | zinc finger protein 23 | 2.16024 |
| SLC75A1 | solute carrier family 75 member 1 | 2.15806 |
| TMEM268 | transmembrane protein 268 | 2.13636 |
| NAT10 | N-acetyltransferase 10 (GCN5-related) | 2.12473 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 2.10997 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.10839 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 2.10114 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | 2.08325 |
| AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | 2.06183 |
| KPNA3 | karyopherin alpha 3 (importin alpha 4) | 2.05086 |
| LGMN | legumain | 2.0424 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.03995 |
| ZNF706 | zinc finger protein 706 | 2.01973 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | 2.01859 |
| TBPL1 | TBP-like 1 | 2.00759 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 2.00754 |
| IFNG | interferon, gamma | 2.00402 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 2.00215 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RNF167 | ring finger protein 167 | -5.10609 |
| TRAPPC3 | trafficking protein particle complex 3 | -5.05892 |
| HAT1 | histone acetyltransferase 1 | -4.36643 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | -4.26035 |
| DNM1L | dynamin 1-like | -4.20969 |
| MRPS15 | mitochondrial ribosomal protein S15 | -3.57586 |
| SMC1A | structural maintenance of chromosomes 1A | -3.26175 |
| MSN | moesin | -3.20991 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -3.03642 |
| QPRT | quinolinate phosphoribosyltransferase | -2.95851 |
| SLC35F2 | solute carrier family 35, member F2 | -2.92196 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -2.89198 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -2.85752 |
| KDM5C | lysine (K)-specific demethylase 5C | -2.81428 |
| PMM2 | phosphomannomutase 2 | -2.7901 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -2.78427 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -2.71318 |
| STXBP2 | syntaxin binding protein 2 | -2.64965 |
| ECHDC2 | enoyl CoA hydratase domain containing 2 | -2.55833 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | -2.53757 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -2.51701 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -2.4812 |
| RNF146 | ring finger protein 146 | -2.44168 |
| DOK2 | docking protein 2, 56kDa | -2.42634 |
| TRIM66 | tripartite motif containing 66 | -2.35556 |
| CNTN1 | contactin 1 | -2.31387 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | -2.30015 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | -2.29401 |
| LYPD1 | LY6/PLAUR domain containing 1 | -2.29368 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -2.28246 |
| USP48 | ubiquitin specific peptidase 48 | -2.28241 |
| MYO1F | myosin IF | -2.27575 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -2.2738 |
| LGALSL | lectin, galactoside-binding-like | -2.25261 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | -2.23141 |
| HDAC1 | histone deacetylase 1 | -2.22554 |
| TTC38 | tetratricopeptide repeat domain 38 | -2.21098 |
| TUFT1 | tuftelin 1 | -2.20726 |
| AKIRIN1 | akirin 1 | -2.2024 |
| FAIM | Fas apoptotic inhibitory molecule | -2.1902 |
| PGLS | 6-phosphogluconolactonase | -2.17296 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -2.16544 |
| PRR13 | proline rich 13 | -2.1638 |
| VAMP8 | vesicle-associated membrane protein 8 | -2.15787 |
| ISG15 | ISG15 ubiquitin-like modifier | -2.1541 |
| RNF2 | ring finger protein 2 | -2.15324 |
| ZNF562 | zinc finger protein 562 | -2.15242 |
| DENND1A | DENN/MADD domain containing 1A | -2.14574 |
| LOC124905557 | eukaryotic translation initiation factor 1A, X-chromosomal | -2.14282 |
| SPI1 | Spi-1 proto-oncogene | -2.11734 |
| SETMAR | SET domain and mariner transposase fusion gene | -2.10878 |
| LMBR1L | limb development membrane protein 1-like | -2.09737 |
| ZNF93 | zinc finger protein 93 | -2.09592 |
| MAVS | mitochondrial antiviral signaling protein | -2.08782 |
| TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | -2.07409 |
| C1QBP | complement component 1, q subcomponent binding protein | -2.06089 |
| EFNA3 | ephrin-A3 | -2.05245 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | -2.03614 |
| CDK5 | cyclin-dependent kinase 5 | -2.03216 |
| NDUFB11 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa | -2.02148 |
| APEH | acylaminoacyl-peptide hydrolase | -2.01676 |
| RRM2 | ribonucleotide reductase M2 | -2.00871 |
| TRNAU1AP | tRNA selenocysteine 1 associated protein 1 | -2.00565 |
| ZNF217 | zinc finger protein 217 | -2.0036 |
