CRCGN015_MCF10A.WT.HP_24H:M03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitromethane 11.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.85976
TGFB3 transforming growth factor, beta 3 4.57001
E2F2 E2F transcription factor 2 3.6657
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.93849
SYNGAP1 synaptic Ras GTPase activating protein 1 2.87841
CDK19 cyclin-dependent kinase 19 2.74908
WIF1 WNT inhibitory factor 1 2.73071
CENPE centromere protein E, 312kDa 2.68801
FYN FYN proto-oncogene, Src family tyrosine kinase 2.6254
GET1 guided entry of tail-anchored proteins factor 1 2.57811
HMGN1 high mobility group nucleosome binding domain 1 2.53172
CHEK2 checkpoint kinase 2 2.45808
RPP38 ribonuclease P/MRP 38kDa subunit 2.11402
RNF139 ring finger protein 139 2.11027
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.10685
PTER phosphotriesterase related 2.06791
CFAP298 cilia and flagella associated protein 298 2.03249
PRB2 proline-rich protein BstNI subfamily 2 2.00399

decreased expression

Symbol Name Standardized Value
STXBP2 syntaxin binding protein 2 -4.77091
HMG20B high mobility group 20B -4.66082
TKT transketolase -4.42211
BPHL biphenyl hydrolase-like (serine hydrolase) -4.38018
GDF15 growth differentiation factor 15 -4.31973
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.06474
FOS FBJ murine osteosarcoma viral oncogene homolog -3.93162
RPIA ribose 5-phosphate isomerase A -3.85239
COG2 component of oligomeric golgi complex 2 -3.66025
MRPS2 mitochondrial ribosomal protein S2 -3.30973
CANT1 calcium activated nucleotidase 1 -2.99658
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.87896
RBM34 RNA binding motif protein 34 -2.76329
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.53782
SCYL3 SCY1-like 3 (S. cerevisiae) -2.47583
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.45194
ATP11B ATPase, class VI, type 11B -2.40567
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.40414
TSC1 tuberous sclerosis 1 -2.39452
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.36471
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.20162
PAEP progestagen-associated endometrial protein -2.19166
RTCA RNA 3'-terminal phosphate cyclase -2.17659
SEC16A SEC16 homolog A (S. cerevisiae) -2.17638
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.17492
ATP5F1D ATP synthase F1 subunit delta -2.16476
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -2.13146
NUAK2 NUAK family, SNF1-like kinase, 2 -2.12052
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.09751
PDZK1IP1 PDZK1 interacting protein 1 -2.08886
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.05631
GALT galactose-1-phosphate uridylyltransferase -2.03444
CEMIP cell migration inducing protein, hyaluronan binding -2.03194
TMEM214 transmembrane protein 214 -2.02913
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.01069
PRRC2B proline-rich coiled-coil 2B -2.00189