CRCGN015_MCF10A.WT.HP_24H:M04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimethyl hydrogen phosphite 100.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.00757
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.59543
CCP110 centriolar coiled coil protein 110kDa 3.03335
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.86676
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.45001
MSRA methionine sulfoxide reductase A 2.39627
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.38584
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.33116
ADGRE5 adhesion G protein-coupled receptor E5 2.22807
TBPL1 TBP-like 1 2.22497
CERK ceramide kinase 2.22479
PKN1 protein kinase N1 2.21126
WIF1 WNT inhibitory factor 1 2.19764
THAP12 THAP domain containing 12 2.1647
GAB2 GRB2-associated binding protein 2 2.10628
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 2.0366
RSF1 remodeling and spacing factor 1 2.03564
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.01069
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.00919

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -4.23882
SLC35F2 solute carrier family 35, member F2 -3.79919
CDC45 cell division cycle 45 -3.44057
MRPS2 mitochondrial ribosomal protein S2 -3.35398
MSMO1 methylsterol monooxygenase 1 -3.26105
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.16092
TKT transketolase -3.12699
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.04026
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.93474
CD81 CD81 molecule -2.79741
PAEP progestagen-associated endometrial protein -2.76606
S100A8 S100 calcium binding protein A8 -2.59185
PSRC1 proline/serine-rich coiled-coil 1 -2.52889
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.48164
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.46224
BASP1 brain abundant, membrane attached signal protein 1 -2.44529
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.44242
COQ4 coenzyme Q4 -2.41477
NT5DC2 5'-nucleotidase domain containing 2 -2.41014
TENT4A terminal nucleotidyltransferase 4A -2.39981
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.37909
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.24116
SYNGR2 synaptogyrin 2 -2.19816
CORO1A coronin, actin binding protein, 1A -2.18107
HMG20B high mobility group 20B -2.17142
CLTB clathrin, light chain B -2.13993
CA8 carbonic anhydrase VIII -2.13671
KREMEN2 kringle containing transmembrane protein 2 -2.11743
UBAC1 UBA domain containing 1 -2.11525
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.10153
RCC1L RCC1 like -2.092
CDKN2A cyclin-dependent kinase inhibitor 2A -2.04772
TLK2 tousled-like kinase 2 -2.02397
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.02025
DGCR6L DiGeorge syndrome critical region gene 6-like -2.00454
PPDPF pancreatic progenitor cell differentiation and proliferation factor -2.00395