CRCGN015_MCF10A.WT.HP_24H:M10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylhydrazine sulfate 100.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.25082
AMDHD2 amidohydrolase domain containing 2 3.97081
CXCL2 chemokine (C-X-C motif) ligand 2 3.73973
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.60296
KLHL21 kelch-like family member 21 3.11509
MELK maternal embryonic leucine zipper kinase 2.73228
ACAA1 acetyl-CoA acyltransferase 1 2.69608
SNAP25 synaptosomal-associated protein, 25kDa 2.65397
AGR2 anterior gradient 2 2.07682
PSPC1 paraspeckle component 1 2.05757
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 2.01925

decreased expression

Symbol Name Standardized Value
CD58 CD58 molecule -3.28599
TLK2 tousled-like kinase 2 -3.10446
TRAPPC3 trafficking protein particle complex 3 -3.01398
CHIC2 cysteine-rich hydrophobic domain 2 -2.9337
DYNLT3 dynein, light chain, Tctex-type 3 -2.82337
DCK deoxycytidine kinase -2.4437
OXA1L oxidase (cytochrome c) assembly 1-like -2.42722
PFN1 profilin 1 -2.3504
PCCB propionyl CoA carboxylase, beta polypeptide -2.29615
TRIB3 tribbles pseudokinase 3 -2.24674
UBA6 ubiquitin-like modifier activating enzyme 6 -2.06943
FPR3 formyl peptide receptor 3 -2.06341
NCF2 neutrophil cytosolic factor 2 -2.01431