CRCGN015_MCF10A.WT.HP_24H:M13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 96.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

22 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 6.81595
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.96644
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.63976
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.91824
RAB31 RAB31, member RAS oncogene family 2.36926
CCNA1 cyclin A1 2.32415
SLC75A1 solute carrier family 75 member 1 2.30755
ABHD4 abhydrolase domain containing 4 2.27293
DENND2D DENN/MADD domain containing 2D 2.2378
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.20466
SPAG4 sperm associated antigen 4 2.16075
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 2.07733
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.06824

decreased expression

Symbol Name Standardized Value
PARP2 poly (ADP-ribose) polymerase 2 -4.61258
CYCS cytochrome c, somatic -4.40748
PCNA proliferating cell nuclear antigen -3.19112
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.98533
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.95501
RPA3 replication protein A3, 14kDa -2.85899
TES testin LIM domain protein -2.34523
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.25355
FBXO7 F-box protein 7 -2.15316