CRCGN015_MCF10A.WT.HP_24H:M14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 32.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

75 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.16404
KLHL21 kelch-like family member 21 4.68743
PPARG peroxisome proliferator-activated receptor gamma 4.40724
AXIN1 axin 1 4.06204
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.89932
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.43053
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.02355
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.91991
MAP2K5 mitogen-activated protein kinase kinase 5 2.87983
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.82557
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.62288
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.58674
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.57598
ZFAND5 zinc finger, AN1-type domain 5 2.44053
ZC3H4 zinc finger CCCH-type containing 4 2.3633
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.32143
IL2RG interleukin 2 receptor, gamma 2.29326
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.28075
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 2.27092
SATB1 SATB homeobox 1 2.25484
PARN poly(A)-specific ribonuclease 2.22578
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.21936
PCDHB11 protocadherin beta 11 2.21125
CA3 carbonic anhydrase III 2.19941
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.19935
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.19299
GOLGA6L9 golgin A6 family-like 9 2.17253
NAE1 NEDD8 activating enzyme E1 subunit 1 2.14771
DNTT DNA nucleotidylexotransferase 2.0983
NPIPB5 nuclear pore complex interacting protein family, member B5 2.02977
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.0049

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -5.83556
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -5.33044
NPDC1 neural proliferation, differentiation and control, 1 -5.25796
GOLT1B golgi transport 1B -4.80441
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.44385
PCCB propionyl CoA carboxylase, beta polypeptide -4.42007
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -4.13399
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.75762
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -3.40599
FAIM Fas apoptotic inhibitory molecule -3.37713
ERGIC2 ERGIC and golgi 2 -3.19106
CANT1 calcium activated nucleotidase 1 -2.91641
RECQL RecQ helicase-like -2.864
TCTA T-cell leukemia translocation altered -2.76283
MAGEH1 melanoma antigen family H1 -2.65077
SEC62 SEC62 homolog (S. cerevisiae) -2.60267
TMEM39A transmembrane protein 39A -2.42588
INTS13 integrator complex subunit 13 -2.39677
GORASP2 golgi reassembly stacking protein 2, 55kDa -2.39483
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.38267
NTAQ1 N-terminal glutamine amidase 1 -2.36268
CRIP2 cysteine-rich protein 2 -2.34566
SIL1 SIL1 nucleotide exchange factor -2.3172
TTC9 tetratricopeptide repeat domain 9 -2.29007
YEATS2 YEATS domain containing 2 -2.26621
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.2295
MSMO1 methylsterol monooxygenase 1 -2.22642
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.22522
ZNF467 zinc finger protein 467 -2.21645
MAIP1 matrix AAA peptidase interacting protein 1 -2.20939
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -2.19942
SCAMP4 secretory carrier membrane protein 4 -2.18965
PLXND1 plexin D1 -2.17451
CD81 CD81 molecule -2.16128
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase -2.11443
PPDPF pancreatic progenitor cell differentiation and proliferation factor -2.11392
STRA6 stimulated by retinoic acid 6 -2.11384
ZHX2 zinc fingers and homeoboxes 2 -2.10555
PLAAT4 phospholipase A and acyltransferase 4 -2.07911
IFNGR1 interferon gamma receptor 1 -2.07567
INF2 inverted formin, FH2 and WH2 domain containing -2.0678
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -2.05264
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.03793
MCTS1 malignant T cell amplified sequence 1 -2.00242