CRCGN015_MCF10A.WT.HP_24H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 10.76 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 4.3387
TLR4 toll-like receptor 4 3.9357
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.88377
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.35142
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.15967
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.1368
RBBP5 retinoblastoma binding protein 5 3.12097
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.80536
SBNO1 strawberry notch homolog 1 (Drosophila) 2.7356
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.64581
GET1 guided entry of tail-anchored proteins factor 1 2.45701
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.35287
TBX2 T-box 2 2.32757
WIF1 WNT inhibitory factor 1 2.28
C5AR1 complement component 5a receptor 1 2.19936
FBXO11 F-box protein 11 2.19126
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.17479
OSTF1 osteoclast stimulating factor 1 2.15802
GSR glutathione reductase 2.1479
NUTF2 nuclear transport factor 2 2.08512
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.05227
MTA2 metastasis associated 1 family, member 2 2.01127
CRIPT cysteine-rich PDZ-binding protein 2.0053

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -3.55621
MPC2 mitochondrial pyruvate carrier 2 -2.95959
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.70705
HAT1 histone acetyltransferase 1 -2.62142
TENT4A terminal nucleotidyltransferase 4A -2.44799
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.02792
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.02649
LMF2 lipase maturation factor 2 -2.02593
GDF15 growth differentiation factor 15 -2.00572