CRCGN015_MCF10A.WT.HP_24H:M18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cadmium chloride 11.14 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 9.26154
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.59924
BPHL biphenyl hydrolase-like (serine hydrolase) 3.566
HMOX1 heme oxygenase 1 3.35406
ARID5B AT rich interactive domain 5B (MRF1-like) 3.33104
NUCB2 nucleobindin 2 3.08577
MMP1 matrix metallopeptidase 1 2.90665
ACAA1 acetyl-CoA acyltransferase 1 2.85545
TIAM1 T-cell lymphoma invasion and metastasis 1 2.75351
MTM1 myotubularin 1 2.68353
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 2.64649
ANKRD6 ankyrin repeat domain 6 2.59689
FBXL2 F-box and leucine-rich repeat protein 2 2.56806
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.52474
TBX19 T-box 19 2.51813
DLL3 delta-like 3 (Drosophila) 2.49752
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.47004
GRIA3 glutamate receptor, ionotropic, AMPA 3 2.46239
HINT1 histidine triad nucleotide binding protein 1 2.46021
CERK ceramide kinase 2.43002
ZNF711 zinc finger protein 711 2.41662
THNSL1 threonine synthase-like 1 (S. cerevisiae) 2.41314
HSPA12A heat shock 70kDa protein 12A 2.38379
RHEX regulator of hemoglobinization and erythroid cell expansion 2.33963
ARMCX6 armadillo repeat containing, X-linked 6 2.31673
MAGEC1 melanoma antigen family C1 2.29178
UFD1 ubiquitin recognition factor in ER associated degradation 1 2.27343
GPR171 G protein-coupled receptor 171 2.24814
MAPT microtubule-associated protein tau 2.23896
SMIM41 small integral membrane protein 41 2.19717
ARHGAP15 Rho GTPase activating protein 15 2.19252
PDZK1 PDZ domain containing 1 2.183
SLITRK2 SLIT and NTRK-like family, member 2 2.17613
TMEM255A transmembrane protein 255A 2.17147
BCAN brevican 2.16975
OLIG2 oligodendrocyte lineage transcription factor 2 2.16867
IPP intracisternal A particle-promoted polypeptide 2.16571
WNT2 wingless-type MMTV integration site family member 2 2.16427
KIAA1549L KIAA1549-like 2.16336
KRCC1 lysine-rich coiled-coil 1 2.16187
KRT38 keratin 38, type I 2.16094
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.15309
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.14589
NVL nuclear VCP-like 2.14116
AKR1D1 aldo-keto reductase family 1, member D1 2.1356
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.13298
ABI1 abl-interactor 1 2.13219
SP140 SP140 nuclear body protein 2.12517
COPS4 COP9 signalosome subunit 4 2.09225
CFHR3 complement factor H-related 3 2.09063
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.08732
HPS5 Hermansky-Pudlak syndrome 5 2.07923
ZNF184 zinc finger protein 184 2.07807
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.07617
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.07573
ERCC6 excision repair cross-complementation group 6 2.07368
SKAP1 src kinase associated phosphoprotein 1 2.06979
NTAQ1 N-terminal glutamine amidase 1 2.06091
GPR19 G protein-coupled receptor 19 2.05948
ZFYVE21 zinc finger, FYVE domain containing 21 2.05304
MATN2 matrilin 2 2.04669
ATP8B4 ATPase, class I, type 8B, member 4 2.04654
C1QL1 complement component 1, q subcomponent-like 1 2.04572
GALR1 galanin receptor 1 2.03982
GFRA1 GDNF family receptor alpha 1 2.03967
ANKRD28 ankyrin repeat domain 28 2.03143
MELTF melanotransferrin 2.01692
ICOS inducible T-cell co-stimulator 2.00984
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 2.00494
PRR13 proline rich 13 2.004

decreased expression

Symbol Name Standardized Value
TSPAN4 tetraspanin 4 -5.34823
BASP1 brain abundant, membrane attached signal protein 1 -4.94451
MSN moesin -4.34195
CHMP4B charged multivesicular body protein 4B -4.20213
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.11293
CCNB1 cyclin B1 -4.07647
ACOT9 acyl-CoA thioesterase 9 -4.04279
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.61445
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.60848
PCCB propionyl CoA carboxylase, beta polypeptide -3.5907
GDF15 growth differentiation factor 15 -3.20451
VEGFD vascular endothelial growth factor D -2.71175
TMEM115 transmembrane protein 115 -2.65856
IFRD2 interferon-related developmental regulator 2 -2.60057
IRS2 insulin receptor substrate 2 -2.55008
IFNGR1 interferon gamma receptor 1 -2.48421
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.38968
GBE1 glucan (1,4-alpha-), branching enzyme 1 -2.38861
MATK megakaryocyte-associated tyrosine kinase -2.36343
UBE2M ubiquitin-conjugating enzyme E2M -2.28781
POGLUT2 protein O-glucosyltransferase 2 -2.28438
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.16954
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.16091
HYAL2 hyaluronoglucosaminidase 2 -2.13956
TMED1 transmembrane emp24 protein transport domain containing 1 -2.07769
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.076
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.05561
VASP vasodilator-stimulated phosphoprotein -2.04514
LRRC59 leucine rich repeat containing 59 -2.02922
SPRY2 sprouty homolog 2 (Drosophila) -2.02365
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -2.02325
FBXO31 F-box protein 31 -2.01761
MMD monocyte to macrophage differentiation-associated -2.01504