CRCGN015_MCF10A.WT.HP_24H:M22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitropyrene 101.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

208 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 8.47107
CDPF1 cysteine-rich, DPF motif domain containing 1 7.75664
SESN1 sestrin 1 7.51585
RGS2 regulator of G-protein signaling 2 6.84117
GPER1 G protein-coupled estrogen receptor 1 6.42684
INPP1 inositol polyphosphate-1-phosphatase 5.54199
DDB2 damage-specific DNA binding protein 2, 48kDa 5.42071
FDXR ferredoxin reductase 4.46579
LRP10 low density lipoprotein receptor-related protein 10 4.39897
GRN granulin 4.20488
DUSP14 dual specificity phosphatase 14 4.0428
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.77535
AEN apoptosis enhancing nuclease 3.52611
COQ8A coenzyme Q8A 3.51351
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.43459
SMAD3 SMAD family member 3 3.40837
RPS27L ribosomal protein S27-like 3.31111
FPGS folylpolyglutamate synthase 3.2496
BAX BCL2-associated X protein 3.23644
TRIAP1 TP53 regulated inhibitor of apoptosis 1 3.22885
STIMATE STIM activating enhancer 3.2081
MICALL1 MICAL-like 1 3.076
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.02261
SKIC2 SKI2 subunit of superkiller complex 2.9879
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.96695
ABHD4 abhydrolase domain containing 4 2.93919
SNAP25 synaptosomal-associated protein, 25kDa 2.89625
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.89303
CCDC90B coiled-coil domain containing 90B 2.88317
FHL2 four and a half LIM domains 2 2.86135
MEF2C myocyte enhancer factor 2C 2.76673
RALGDS ral guanine nucleotide dissociation stimulator 2.75176
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.74636
TERF2IP telomeric repeat binding factor 2, interacting protein 2.70349
IFI30 interferon, gamma-inducible protein 30 2.66953
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 2.66199
EMC6 ER membrane protein complex subunit 6 2.66104
TIGAR TP53 induced glycolysis regulatory phosphatase 2.62863
PDGFA platelet-derived growth factor alpha polypeptide 2.62468
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.62391
TRIM22 tripartite motif containing 22 2.6237
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.61706
DERA deoxyribose-phosphate aldolase (putative) 2.57933
CCP110 centriolar coiled coil protein 110kDa 2.52258
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.4977
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.494
PRAF2 PRA1 domain family, member 2 2.4928
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 2.47978
HBA1 hemoglobin, alpha 1 2.47822
NOSIP nitric oxide synthase interacting protein 2.47806
BTG2 BTG family, member 2 2.47765
NLRX1 NLR family member X1 2.47362
AAMDC adipogenesis associated, Mth938 domain containing 2.46978
NGRN neugrin, neurite outgrowth associated 2.4697
ECI2 enoyl-CoA delta isomerase 2 2.45717
TCEA2 transcription elongation factor A (SII), 2 2.44273
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.42355
NISCH nischarin 2.38664
PLK2 polo-like kinase 2 2.38039
EPHA2 EPH receptor A2 2.37581
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 2.37518
LAGE3 L antigen family, member 3 2.37219
B4GAT1 beta-1,4-glucuronyltransferase 1 2.36524
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.35843
MRPL33 mitochondrial ribosomal protein L33 2.35577
XPC xeroderma pigmentosum, complementation group C 2.34963
ZBTB32 zinc finger and BTB domain containing 32 2.34688
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.34472
ELP5 elongator acetyltransferase complex subunit 5 2.34257
PNPO pyridoxamine 5'-phosphate oxidase 2.33532
GALE UDP-galactose-4-epimerase 2.33029
ISCU iron-sulfur cluster assembly enzyme 2.32872
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.32849
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.32773
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.31025
CEMIP2 cell migration inducing hyaluronidase 2 2.28141
ZNF79 zinc finger protein 79 2.27716
MYOT myotilin 2.27452
PCNA proliferating cell nuclear antigen 2.26918
SMG8 SMG8 nonsense mediated mRNA decay factor 2.2603
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.24897
RAP1GAP2 RAP1 GTPase activating protein 2 2.24108
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.2395
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.23364
NEFL neurofilament, light polypeptide 2.23238
PARP3 poly (ADP-ribose) polymerase family, member 3 2.22817
RUNDC3B RUN domain containing 3B 2.2224
ZMAT3 zinc finger, matrin-type 3 2.20708
TUSC2 tumor suppressor candidate 2 2.20695
ERCC3 excision repair cross-complementation group 3 2.2047
MINDY1 MINDY lysine 48 deubiquitinase 1 2.20119
ZMIZ1 zinc finger, MIZ-type containing 1 2.19226
HMOX1 heme oxygenase 1 2.18308
TDRD7 tudor domain containing 7 2.18254
TRIM21 tripartite motif containing 21 2.17644
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.15823
SCAMP2 secretory carrier membrane protein 2 2.14136
NME5 NME/NM23 family member 5 2.13724
GSAP gamma-secretase activating protein 2.12034
PRKX protein kinase, X-linked 2.11884
PPME1 protein phosphatase methylesterase 1 2.11019
MYL5 myosin, light chain 5, regulatory 2.10176
ABHD14A abhydrolase domain containing 14A 2.08981
TBX2 T-box 2 2.08414
NINJ1 ninjurin 1 2.08314
IFI35 interferon-induced protein 35 2.08007
SCAND1 SCAN domain containing 1 2.07923
ETNPPL ethanolamine-phosphate phospho-lyase 2.06743
MICA MHC class I polypeptide-related sequence A 2.06614
ITPRID2 ITPR interacting domain containing 2 2.06363
CCDC92 coiled-coil domain containing 92 2.06158
ZNF226 zinc finger protein 226 2.06053
GSTZ1 glutathione S-transferase zeta 1 2.05962
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.05886
MPPE1 metallophosphoesterase 1 2.04535
GAMT guanidinoacetate N-methyltransferase 2.04054
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.03811
PLK3 polo-like kinase 3 2.03625
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.0313
RWDD2B RWD domain containing 2B 2.02774
RTP4 receptor (chemosensory) transporter protein 4 2.02168
IL21R interleukin 21 receptor 2.01929
HCFC2 host cell factor C2 2.00899
BLCAP bladder cancer associated protein 2.00839
FBXO2 F-box protein 2 2.00424
SPATA20 spermatogenesis associated 20 2.0019
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.00145
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.00113

decreased expression

Symbol Name Standardized Value
MSRA methionine sulfoxide reductase A -7.72979
PSRC1 proline/serine-rich coiled-coil 1 -5.99471
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -4.9007
UBE2C ubiquitin-conjugating enzyme E2C -4.75593
MSMO1 methylsterol monooxygenase 1 -4.7424
ANXA2 annexin A2 -4.19927
LBR lamin B receptor -4.14458
DDIT4 DNA-damage-inducible transcript 4 -3.97511
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.82955
THAP11 THAP domain containing 11 -3.60953
TOP2A topoisomerase (DNA) II alpha 170kDa -3.58402
SSBP2 single-stranded DNA binding protein 2 -3.54737
ELOVL6 ELOVL fatty acid elongase 6 -3.51445
ANO10 anoctamin 10 -3.46235
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -3.23712
CRTAP cartilage associated protein -3.22896
EPHB2 EPH receptor B2 -3.12903
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -3.11746
BID BH3 interacting domain death agonist -2.89305
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -2.87557
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -2.85179
TMEM109 transmembrane protein 109 -2.84301
PTK2 protein tyrosine kinase 2 -2.76748
MCM3 minichromosome maintenance complex component 3 -2.7461
INSIG1 insulin induced gene 1 -2.72531
TRIM24 tripartite motif containing 24 -2.72496
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -2.68698
KIF15 kinesin family member 15 -2.68215
SLC35F2 solute carrier family 35, member F2 -2.57094
COL4A1 collagen, type IV, alpha 1 -2.54281
MAPK13 mitogen-activated protein kinase 13 -2.53866
CCNB2 cyclin B2 -2.53251
CHMP4B charged multivesicular body protein 4B -2.52284
RPIA ribose 5-phosphate isomerase A -2.50346
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.48518
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.4818
CDC25B cell division cycle 25B -2.47128
ATF6 activating transcription factor 6 -2.46148
CDC20 cell division cycle 20 -2.41628
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.40811
TCTA T-cell leukemia translocation altered -2.40027
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.40022
PDGFC platelet derived growth factor C -2.39443
COG7 component of oligomeric golgi complex 7 -2.38815
NCAPD2 non-SMC condensin I complex, subunit D2 -2.38673
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.38214
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.35003
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -2.33715
ANKRD28 ankyrin repeat domain 28 -2.3092
NTHL1 nth endonuclease III-like 1 (E. coli) -2.29941
CADPS2 Ca++-dependent secretion activator 2 -2.27636
MGA MGA, MAX dimerization protein -2.22929
RSU1 Ras suppressor protein 1 -2.21068
MSH2 mutS homolog 2 -2.20855
HILPDA hypoxia inducible lipid droplet-associated -2.18504
OIP5 Opa interacting protein 5 -2.17108
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.16847
AURKA aurora kinase A -2.15796
SETD3 SET domain containing 3 -2.15018
PHKB phosphorylase kinase, beta -2.14772
RBM6 RNA binding motif protein 6 -2.14075
CNN3 calponin 3, acidic -2.13355
RAB5B RAB5B, member RAS oncogene family -2.13174
PLK1 polo-like kinase 1 -2.11854
NFIL3 nuclear factor, interleukin 3 regulated -2.11663
FBLN5 fibulin 5 -2.11465
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.11227
NUSAP1 nucleolar and spindle associated protein 1 -2.11104
GPD1L glycerol-3-phosphate dehydrogenase 1-like -2.10357
GRB10 growth factor receptor-bound protein 10 -2.08083
AFAP1 actin filament associated protein 1 -2.07191
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.06246
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -2.05281
SEC61G Sec61 gamma subunit -2.04444
GSTM5 glutathione S-transferase mu 5 -2.04357
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.04335
KIF11 kinesin family member 11 -2.03189
CLEC5A C-type lectin domain family 5, member A -2.02003
ERG v-ets avian erythroblastosis virus E26 oncogene homolog -2.00602
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -2.00253