CRCGN015_MCF10A.WT.HP_24H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitropyrene 33.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

255 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 8.28352
SESN1 sestrin 1 7.00706
RGS2 regulator of G-protein signaling 2 6.95115
INPP1 inositol polyphosphate-1-phosphatase 5.61356
WIF1 WNT inhibitory factor 1 5.49263
DDB2 damage-specific DNA binding protein 2, 48kDa 4.94898
LRP10 low density lipoprotein receptor-related protein 10 4.77291
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.35524
SPAG4 sperm associated antigen 4 4.30011
DUSP14 dual specificity phosphatase 14 4.28615
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.2586
AEN apoptosis enhancing nuclease 4.16027
FDXR ferredoxin reductase 4.07724
GRN granulin 3.92354
GPC1 glypican 1 3.82584
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.80432
CNPY3 canopy FGF signaling regulator 3 3.77503
ABHD4 abhydrolase domain containing 4 3.65923
BAX BCL2-associated X protein 3.65449
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.55198
PRKX protein kinase, X-linked 3.375
NOSIP nitric oxide synthase interacting protein 3.34359
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.31514
CCP110 centriolar coiled coil protein 110kDa 3.20176
GPER1 G protein-coupled estrogen receptor 1 3.19339
SKIC2 SKI2 subunit of superkiller complex 3.09238
MEA1 male-enhanced antigen 1 3.00218
MRPL33 mitochondrial ribosomal protein L33 2.97904
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.9338
MICALL1 MICAL-like 1 2.86491
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.85212
ACADVL acyl-CoA dehydrogenase, very long chain 2.85055
PEX11A peroxisomal biogenesis factor 11 alpha 2.83097
RALGDS ral guanine nucleotide dissociation stimulator 2.8219
GALE UDP-galactose-4-epimerase 2.80372
TWF2 twinfilin actin binding protein 2 2.79814
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.79647
FHL2 four and a half LIM domains 2 2.76601
FPGS folylpolyglutamate synthase 2.74158
WHRN whirlin 2.70794
RING1 ring finger protein 1 2.70596
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.70559
NINJ1 ninjurin 1 2.69914
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.62824
SPATA20 spermatogenesis associated 20 2.62417
GSTZ1 glutathione S-transferase zeta 1 2.58963
DMTN dematin actin binding protein 2.56824
XPC xeroderma pigmentosum, complementation group C 2.53099
MINDY1 MINDY lysine 48 deubiquitinase 1 2.5196
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.50731
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.50085
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.48171
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.48151
ULK1 unc-51 like autophagy activating kinase 1 2.47645
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 2.47609
VGLL4 vestigial-like family member 4 2.45555
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 2.45284
TRIM22 tripartite motif containing 22 2.4455
PLK2 polo-like kinase 2 2.44319
MYL5 myosin, light chain 5, regulatory 2.44264
TCEA2 transcription elongation factor A (SII), 2 2.43994
TUBB6 tubulin, beta 6 class V 2.43742
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 2.42701
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.42284
TBX3 T-box 3 2.41847
NISCH nischarin 2.41662
PPME1 protein phosphatase methylesterase 1 2.40699
TPD52L1 tumor protein D52-like 1 2.393
CEMIP2 cell migration inducing hyaluronidase 2 2.3838
SMAD3 SMAD family member 3 2.37523
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 2.36733
STARD3 StAR-related lipid transfer (START) domain containing 3 2.35771
DGKA diacylglycerol kinase, alpha 80kDa 2.3572
BORCS8 BLOC-1 related complex subunit 8 2.34102
FAM131A family with sequence similarity 131, member A 2.34002
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.33708
CHPF chondroitin polymerizing factor 2.32161
AAMDC adipogenesis associated, Mth938 domain containing 2.31994
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.31417
ZDHHC11B zinc finger, DHHC-type containing 11B 2.2973
KLHL36 kelch-like family member 36 2.29715
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.29126
SPACA9 sperm acrosome associated 9 2.28953
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.28879
MSX2 msh homeobox 2 2.28457
TP53I3 tumor protein p53 inducible protein 3 2.28353
PLK3 polo-like kinase 3 2.27689
SEC14L2 SEC14-like 2 (S. cerevisiae) 2.27447
BTG2 BTG family, member 2 2.26586
MZT2B mitotic spindle organizing protein 2B 2.25194
RPS27L ribosomal protein S27-like 2.24939
MEPE matrix extracellular phosphoglycoprotein 2.23643
ZNF79 zinc finger protein 79 2.23559
AMZ2 archaelysin family metallopeptidase 2 2.23087
PDIA2 protein disulfide isomerase family A, member 2 2.22961
CDK20 cyclin-dependent kinase 20 2.22836
UBXN6 UBX domain protein 6 2.22433
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.22375
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 2.20419
OGDHL oxoglutarate dehydrogenase-like 2.20205
TRIAP1 TP53 regulated inhibitor of apoptosis 1 2.2015
PTCRA pre T-cell antigen receptor alpha 2.19524
MSL1 male-specific lethal 1 homolog (Drosophila) 2.19083
TM7SF2 transmembrane 7 superfamily member 2 2.18622
KLHDC2 kelch domain containing 2 2.17557
REEP2 receptor accessory protein 2 2.17428
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.17296
IRF3 interferon regulatory factor 3 2.17057
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.16975
CDK9 cyclin-dependent kinase 9 2.16661
TKFC triokinase/FMN cyclase 2.16432
IL1B interleukin 1, beta 2.15171
TUBG2 tubulin, gamma 2 2.14996
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 2.14925
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.14575
IZUMO4 IZUMO family member 4 2.14293
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.13712
LOC124904942 uncharacterized LOC124904942 2.13034
FUZ fuzzy planar cell polarity protein 2.12953
APLP1 amyloid beta (A4) precursor-like protein 1 2.12946
ST20-MTHFS ST20-MTHFS readthrough 2.12645
MZT2A mitotic spindle organizing protein 2A 2.12114
GALNS galactosamine (N-acetyl)-6-sulfatase 2.11869
NLRX1 NLR family member X1 2.11464
FAT1 FAT atypical cadherin 1 2.09901
TXLNA taxilin alpha 2.09631
MCOLN1 mucolipin 1 2.09098
CIDEB cell death-inducing DFFA-like effector b 2.08956
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 2.08906
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.0807
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.08038
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.06058
REG1B regenerating islet-derived 1 beta 2.05546
CDH22 cadherin 22, type 2 2.05291
IRS1 insulin receptor substrate 1 2.04172
BBLN bublin coiled coil protein 2.04102
DES desmin 2.03373
CCS copper chaperone for superoxide dismutase 2.03302
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.02751
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.02555
MLF2 myeloid leukemia factor 2 2.01249
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.01078
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.00147
RGS14 regulator of G-protein signaling 14 2.00053

decreased expression

Symbol Name Standardized Value
MSRA methionine sulfoxide reductase A -7.81165
CTNND1 catenin (cadherin-associated protein), delta 1 -5.50933
RPIA ribose 5-phosphate isomerase A -4.75258
PSRC1 proline/serine-rich coiled-coil 1 -4.71575
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.29583
TMX2 thioredoxin-related transmembrane protein 2 -4.07877
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -3.94995
ATF6 activating transcription factor 6 -3.85993
LBR lamin B receptor -3.66344
UBE3C ubiquitin protein ligase E3C -3.60471
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.56865
TSPAN3 tetraspanin 3 -3.50802
CDC20 cell division cycle 20 -3.43861
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.42496
PLK1 polo-like kinase 1 -3.36716
AURKA aurora kinase A -3.3207
S100A8 S100 calcium binding protein A8 -3.23384
MCM3 minichromosome maintenance complex component 3 -3.20598
CLCC1 chloride channel CLIC-like 1 -3.09906
ASCC3 activating signal cointegrator 1 complex subunit 3 -3.08651
MSMO1 methylsterol monooxygenase 1 -3.07148
ANO10 anoctamin 10 -3.05729
KIF15 kinesin family member 15 -3.02633
TCTA T-cell leukemia translocation altered -2.96006
KIF4A kinesin family member 4A -2.94787
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.9396
TOP2A topoisomerase (DNA) II alpha 170kDa -2.89726
CDC25B cell division cycle 25B -2.87298
UBE2C ubiquitin-conjugating enzyme E2C -2.82663
DDIT4 DNA-damage-inducible transcript 4 -2.823
EPHB2 EPH receptor B2 -2.78794
SNX5 sorting nexin 5 -2.76142
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -2.73743
GPHN gephyrin -2.72652
SSBP2 single-stranded DNA binding protein 2 -2.72385
BASP1 brain abundant, membrane attached signal protein 1 -2.71842
CCNA2 cyclin A2 -2.71052
FAT4 FAT atypical cadherin 4 -2.70292
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -2.68015
VDAC1 voltage-dependent anion channel 1 -2.64109
RBM6 RNA binding motif protein 6 -2.63864
ZMYM1 zinc finger, MYM-type 1 -2.60862
RTN3 reticulon 3 -2.58676
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.5687
UFM1 ubiquitin-fold modifier 1 -2.55803
INSIG1 insulin induced gene 1 -2.5536
ARB2A ARB2 cotranscriptional regulator A -2.54869
ELOVL6 ELOVL fatty acid elongase 6 -2.51945
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.44412
SSRP1 structure specific recognition protein 1 -2.41645
NCALD neurocalcin delta -2.41401
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.38981
NFIL3 nuclear factor, interleukin 3 regulated -2.37307
MSN moesin -2.3397
ERG v-ets avian erythroblastosis virus E26 oncogene homolog -2.33895
KPNA3 karyopherin alpha 3 (importin alpha 4) -2.33063
NVL nuclear VCP-like -2.32588
MKKS McKusick-Kaufman syndrome -2.32575
USP39 ubiquitin specific peptidase 39 -2.30828
GTPBP8 GTP-binding protein 8 (putative) -2.29649
CTCF CCCTC-binding factor (zinc finger protein) -2.29603
TTC27 tetratricopeptide repeat domain 27 -2.29404
NUP93 nucleoporin 93kDa -2.28474
OBI1 ORC ubiquitin ligase 1 -2.28276
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.28239
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.27925
MSH2 mutS homolog 2 -2.27679
CEP192 centrosomal protein 192kDa -2.27325
FAR2 fatty acyl CoA reductase 2 -2.26006
TMEM135 transmembrane protein 135 -2.2598
PHKB phosphorylase kinase, beta -2.23619
NUP205 nucleoporin 205kDa -2.22486
KIF14 kinesin family member 14 -2.20955
LEPROTL1 leptin receptor overlapping transcript-like 1 -2.20225
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.19648
AURKB aurora kinase B -2.19062
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.17828
DET1 de-etiolated homolog 1 (Arabidopsis) -2.17425
PTK2 protein tyrosine kinase 2 -2.16364
ARMCX5 armadillo repeat containing, X-linked 5 -2.15128
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.14928
SH3D19 SH3 domain containing 19 -2.13103
BIRC5 baculoviral IAP repeat containing 5 -2.11238
ARHGAP12 Rho GTPase activating protein 12 -2.11014
EXOSC8 exosome component 8 -2.10815
PPARG peroxisome proliferator-activated receptor gamma -2.10809
C2CD5 C2 calcium-dependent domain containing 5 -2.09665
TSPAN8 tetraspanin 8 -2.0831
NHLRC2 NHL repeat containing 2 -2.07908
SRBD1 S1 RNA binding domain 1 -2.07538
TAC4 tachykinin 4 (hemokinin) -2.07454
AKAP12 A kinase (PRKA) anchor protein 12 -2.07086
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.06768
SCYL3 SCY1-like 3 (S. cerevisiae) -2.06571
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.06067
TOX3 TOX high mobility group box family member 3 -2.04818
COG5 component of oligomeric golgi complex 5 -2.04454
ELP4 elongator acetyltransferase complex subunit 4 -2.04003
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -2.03931
METTL18 methyltransferase like 18 -2.03779
COL4A1 collagen, type IV, alpha 1 -2.03253
PIBF1 progesterone immunomodulatory binding factor 1 -2.03247
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -2.03034
ACLY ATP citrate lyase -2.0257
FOXJ3 forkhead box J3 -2.02542
FTO fat mass and obesity associated -2.02203
CANX calnexin -2.02113
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.01679
MYLIP myosin regulatory light chain interacting protein -2.01051
METTL4 methyltransferase like 4 -2.008
CASP8AP2 caspase 8 associated protein 2 -2.00215