CRCGN015_MCF10A.WT.HP_24H:M24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitropyrene 11.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

92 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:M24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 7.5454
WIF1 WNT inhibitory factor 1 5.82917
RGS2 regulator of G-protein signaling 2 4.82149
DDB2 damage-specific DNA binding protein 2, 48kDa 4.66801
INPP1 inositol polyphosphate-1-phosphatase 4.59291
SESN1 sestrin 1 4.33167
GRN granulin 3.93398
GSTZ1 glutathione S-transferase zeta 1 3.86463
KCTD5 potassium channel tetramerization domain containing 5 3.83775
FDXR ferredoxin reductase 3.68558
LYN LYN proto-oncogene, Src family tyrosine kinase 3.6746
MAMLD1 mastermind-like domain containing 1 3.5639
LRP10 low density lipoprotein receptor-related protein 10 3.51171
TXNL4B thioredoxin-like 4B 3.49412
MICALL1 MICAL-like 1 3.37082
SKIC2 SKI2 subunit of superkiller complex 3.35466
TRIAP1 TP53 regulated inhibitor of apoptosis 1 3.23428
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.23365
CCP110 centriolar coiled coil protein 110kDa 3.22306
SNAP25 synaptosomal-associated protein, 25kDa 2.99201
INTS3 integrator complex subunit 3 2.98519
DUSP14 dual specificity phosphatase 14 2.95725
AEN apoptosis enhancing nuclease 2.91294
RPS27L ribosomal protein S27-like 2.90666
BAX BCL2-associated X protein 2.86103
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.76834
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.71938
FHL2 four and a half LIM domains 2 2.54565
RALGDS ral guanine nucleotide dissociation stimulator 2.54106
IGHMBP2 immunoglobulin mu binding protein 2 2.53759
NISCH nischarin 2.51909
MINDY1 MINDY lysine 48 deubiquitinase 1 2.51904
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.48319
ZNF783 zinc finger family member 783 2.44205
TWF2 twinfilin actin binding protein 2 2.36747
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.35091
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.33296
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.31753
TIGAR TP53 induced glycolysis regulatory phosphatase 2.30216
LOC128125822 uncharacterized LOC128125822 2.29237
TCEA2 transcription elongation factor A (SII), 2 2.26114
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.25017
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.22672
ZMAT3 zinc finger, matrin-type 3 2.20872
LCAT lecithin-cholesterol acyltransferase 2.18895
WRAP73 WD repeat containing, antisense to TP73 2.12411
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.12368
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.11877
PLK2 polo-like kinase 2 2.11671
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.0899
MCOLN1 mucolipin 1 2.08707
FAT1 FAT atypical cadherin 1 2.07598
CCDC90B coiled-coil domain containing 90B 2.07353
GET1 guided entry of tail-anchored proteins factor 1 2.06515
TRIP6 thyroid hormone receptor interactor 6 2.06435
XPC xeroderma pigmentosum, complementation group C 2.04802
TRIM22 tripartite motif containing 22 2.04761
HSPA4L heat shock 70kDa protein 4-like 2.04517
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.02857
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.02443

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -4.82908
MSRA methionine sulfoxide reductase A -4.4027
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.90195
SSBP2 single-stranded DNA binding protein 2 -3.45118
LBR lamin B receptor -3.34301
PSRC1 proline/serine-rich coiled-coil 1 -3.30016
MCM3 minichromosome maintenance complex component 3 -3.26526
FOXJ3 forkhead box J3 -2.91412
TOP2A topoisomerase (DNA) II alpha 170kDa -2.83203
TM9SF2 transmembrane 9 superfamily member 2 -2.6427
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.63564
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.61861
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.49757
CCNB1 cyclin B1 -2.4798
ELOVL6 ELOVL fatty acid elongase 6 -2.46197
SMNDC1 survival motor neuron domain containing 1 -2.43253
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.39302
ATF6 activating transcription factor 6 -2.36892
ARHGAP11A Rho GTPase activating protein 11A -2.36752
PLK1 polo-like kinase 1 -2.28451
CDC25B cell division cycle 25B -2.26548
AURKA aurora kinase A -2.18708
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.17596
KIF18A kinesin family member 18A -2.14282
KIF15 kinesin family member 15 -2.12528
WDR7 WD repeat domain 7 -2.12202
NDRG1 N-myc downstream regulated 1 -2.09003
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.08724
CCNB2 cyclin B2 -2.06528
NUSAP1 nucleolar and spindle associated protein 1 -2.03561
DPYD dihydropyrimidine dehydrogenase -2.02521
NFIL3 nuclear factor, interleukin 3 regulated -2.02334