CRCGN015_MCF10A.WT.HP_24H:N08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isobutyl nitrite 32.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:N08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SQOR sulfide quinone oxidoreductase 3.95065
PDIA5 protein disulfide isomerase family A, member 5 3.85752
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.42631
CNRIP1 cannabinoid receptor interacting protein 1 3.03277
SYNGAP1 synaptic Ras GTPase activating protein 1 2.95466
AGR2 anterior gradient 2 2.91349
LOXL1 lysyl oxidase-like 1 2.82884
TXNL4B thioredoxin-like 4B 2.70384
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.67674
PDLIM1 PDZ and LIM domain 1 2.5072
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.45347
WIF1 WNT inhibitory factor 1 2.34131
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.24785
CLCC1 chloride channel CLIC-like 1 2.15012
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.14303
TLCD3A TLC domain containing 3A 2.1327
OLFML3 olfactomedin-like 3 2.1208
MOK MOK protein kinase 2.10724
MUC4 mucin 4, cell surface associated 2.09881
IQGAP1 IQ motif containing GTPase activating protein 1 2.04175
RPP38 ribonuclease P/MRP 38kDa subunit 2.03069

decreased expression

Symbol Name Standardized Value
PLK1 polo-like kinase 1 -6.06382
RNF167 ring finger protein 167 -4.65001
GDF15 growth differentiation factor 15 -4.64874
BPHL biphenyl hydrolase-like (serine hydrolase) -4.19718
HMG20B high mobility group 20B -3.48848
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.23715
SCYL3 SCY1-like 3 (S. cerevisiae) -3.0502
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.88193
METTL17 methyltransferase like 17 -2.82533
TIMP1 TIMP metallopeptidase inhibitor 1 -2.75337
TM9SF2 transmembrane 9 superfamily member 2 -2.25326
MRPL37 mitochondrial ribosomal protein L37 -2.22575
ADGRD2 adhesion G protein-coupled receptor D2 -2.19735
PEG10 paternally expressed 10 -2.19418
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.18536
TRIB3 tribbles pseudokinase 3 -2.15332
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -2.12048
DAD1 defender against cell death 1 -2.09813
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.08011
KIF22 kinesin family member 22 -2.07783
STXBP2 syntaxin binding protein 2 -2.0591
GJB1 gap junction protein, beta 1, 32kDa -2.00135