CRCGN015_MCF10A.WT.HP_24H:N09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isobutyl nitrite 10.7 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:N09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZW10 zw10 kinetochore protein 7.39844
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.79612
MAMLD1 mastermind-like domain containing 1 4.73439
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.35339
ACLY ATP citrate lyase 4.1741
ACAA1 acetyl-CoA acyltransferase 1 3.2374
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 3.23286
MTM1 myotubularin 1 3.14616
IGHMBP2 immunoglobulin mu binding protein 2 2.92892
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.86211
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.84708
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.65625
NOTCH1 notch 1 2.6344
GRAMD2B GRAM domain containing 2B 2.61619
PZP pregnancy-zone protein 2.60644
MORC4 MORC family CW-type zinc finger 4 2.54402
SLC75A1 solute carrier family 75 member 1 2.49064
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.47694
HMGB3 high mobility group box 3 2.43556
EFCAB14 EF-hand calcium binding domain 14 2.41862
TMX2 thioredoxin-related transmembrane protein 2 2.33217
NCAPD3 non-SMC condensin II complex, subunit D3 2.27501
ASB7 ankyrin repeat and SOCS box containing 7 2.24955
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.2434
CAPN7 calpain 7 2.23959
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 2.23402
GGCT gamma-glutamylcyclotransferase 2.20417
PEAK1 pseudopodium-enriched atypical kinase 1 2.15942
THAP12 THAP domain containing 12 2.14804
CASP8AP2 caspase 8 associated protein 2 2.14676
WDR33 WD repeat domain 33 2.14062
NEMF nuclear export mediator factor 2.11532
ANKRD26 ankyrin repeat domain 26 2.10616
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.10527
RDX radixin 2.09243
TMF1 TATA element modulatory factor 1 2.09079
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.08928
STX17 syntaxin 17 2.08463
MRPL17 mitochondrial ribosomal protein L17 2.08104
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.06559
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.06011
MBIP MAP3K12 binding inhibitory protein 1 2.05714
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.04318
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.03344
ANKRD28 ankyrin repeat domain 28 2.02953
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.02783
ZEB2 zinc finger E-box binding homeobox 2 2.02079
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.01606
ABI2 abl-interactor 2 2.01256

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -4.86847
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.41306
RPIA ribose 5-phosphate isomerase A -4.25478
HEATR1 HEAT repeat containing 1 -3.7265
DSG2 desmoglein 2 -3.70477
GDF15 growth differentiation factor 15 -3.3226
FAIM Fas apoptotic inhibitory molecule -3.00882
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.79872
PRSS22 protease, serine, 22 -2.53058
TIMP1 TIMP metallopeptidase inhibitor 1 -2.51481
SRRD SRR1 domain containing -2.48299
TRIB3 tribbles pseudokinase 3 -2.39323
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.37421
BIK BCL2-interacting killer (apoptosis-inducing) -2.34812
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.34113
SH3TC1 SH3 domain and tetratricopeptide repeats 1 -2.33665
ARID5A AT rich interactive domain 5A (MRF1-like) -2.17526
GSTT1 glutathione S-transferase theta 1 -2.17114
NRBP1 nuclear receptor binding protein 1 -2.1612
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 -2.13598
NCF1 neutrophil cytosolic factor 1 -2.12743
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -2.12123
FAM131A family with sequence similarity 131, member A -2.10379
RAP1GAP2 RAP1 GTPase activating protein 2 -2.0971
RALGDS ral guanine nucleotide dissociation stimulator -2.08336
KCMF1 potassium channel modulatory factor 1 -2.07221
AKAP12 A kinase (PRKA) anchor protein 12 -2.0527
CCDC81 coiled-coil domain containing 81 -2.04329
GUK1 guanylate kinase 1 -2.0411
MTX1 metaxin 1 -2.02713
TOR1AIP2 torsin A interacting protein 2 -2.02237
PRSS8 protease, serine, 8 -2.02187
AHDC1 AT hook, DNA binding motif, containing 1 -2.01754
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.00907