CRCGN015_MCF10A.WT.HP_24H:N11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetranitromethane 33.77 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:N11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IDE insulin-degrading enzyme 4.7245
CXCR4 chemokine (C-X-C motif) receptor 4 4.01434
ZNF586 zinc finger protein 586 3.90812
ADRB2 adrenoceptor beta 2, surface 3.69934
NUP205 nucleoporin 205kDa 3.16618
TBPL1 TBP-like 1 2.73822
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.70221
NCK2 NCK adaptor protein 2 2.5446
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.47689
SLC75A1 solute carrier family 75 member 1 2.4663
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 2.28172
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.24567
CUL1 cullin 1 2.17535
PEX12 peroxisomal biogenesis factor 12 2.17027
BLMH bleomycin hydrolase 2.16581
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.16555
TMEM109 transmembrane protein 109 2.16546
ZWILCH zwilch kinetochore protein 2.1178
GCC1 GRIP and coiled-coil domain containing 1 2.11228
ZNF134 zinc finger protein 134 2.00369
ZMYM4 zinc finger, MYM-type 4 2.00032

decreased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 -4.96621
GOLT1B golgi transport 1B -4.72027
PCCB propionyl CoA carboxylase, beta polypeptide -4.59079
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -4.55718
SLC25A46 solute carrier family 25, member 46 -4.50677
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa -3.68648
GDF15 growth differentiation factor 15 -3.66575
ARID4B AT rich interactive domain 4B (RBP1-like) -3.46207
TENT4A terminal nucleotidyltransferase 4A -3.29777
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -3.25047
FAM131A family with sequence similarity 131, member A -3.14127
AP2M1 adaptor-related protein complex 2, mu 1 subunit -3.00585
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.74018
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.72043
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.58366
GADD45B growth arrest and DNA-damage-inducible, beta -2.57606
TBCCD1 TBCC domain containing 1 -2.54081
BASP1 brain abundant, membrane attached signal protein 1 -2.52146
RECQL RecQ helicase-like -2.43732
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.39551
MAGEF1 melanoma antigen family F1 -2.37439
STXBP2 syntaxin binding protein 2 -2.3633
MAGEH1 melanoma antigen family H1 -2.32454
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.25322
RALGDS ral guanine nucleotide dissociation stimulator -2.22377
PLAAT1 phospholipase A and acyltransferase 1 -2.21775
ZNF536 zinc finger protein 536 -2.20926
RAB4B RAB4B, member RAS oncogene family -2.20304
IFNG interferon, gamma -2.20289
STAG3 stromal antigen 3 -2.19952
HIKESHI heat shock protein nuclear import factor hikeshi -2.1854
SOD1 superoxide dismutase 1, soluble -2.1657
SCGN secretagogin, EF-hand calcium binding protein -2.14587
PDCD10 programmed cell death 10 -2.14113
LACTB2 lactamase, beta 2 -2.12353
CORO1A coronin, actin binding protein, 1A -2.12109
YEATS2 YEATS domain containing 2 -2.11733
NKX2-2 NK2 homeobox 2 -2.1101
SGK1 serum/glucocorticoid regulated kinase 1 -2.09947
YIPF4 Yip1 domain family, member 4 -2.0867
RGS18 regulator of G-protein signaling 18 -2.07608
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 -2.06375
MTMR14 myotubularin related protein 14 -2.05709
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -2.04361
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.04042
ACTL6A actin-like 6A -2.02175
IL3 interleukin 3 -2.00782