CRCGN015_MCF10A.WT.HP_24H:N14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cobalt sulfate heptahydrate 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:N14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TOPBP1 topoisomerase (DNA) II binding protein 1 4.00576
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.59318
E2F2 E2F transcription factor 2 3.46271
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.33872
SNAP25 synaptosomal-associated protein, 25kDa 2.9199
TBPL1 TBP-like 1 2.77132
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.74608
PEX11A peroxisomal biogenesis factor 11 alpha 2.64141
SV2B synaptic vesicle glycoprotein 2B 2.33762
CCNA1 cyclin A1 2.33229
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.17235
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.12973
STMN2 stathmin 2 2.12157
NSG2 neuronal vesicle trafficking associated 2 2.10407
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.04919
NRBF2 nuclear receptor binding factor 2 2.03483
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.02924

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -6.43912
TES testin LIM domain protein -3.93731
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.99934
DSG2 desmoglein 2 -2.75208
CTNND1 catenin (cadherin-associated protein), delta 1 -2.66162
MSMO1 methylsterol monooxygenase 1 -2.5971
TIMP1 TIMP metallopeptidase inhibitor 1 -2.51578
MEST mesoderm specific transcript -2.1233
FBXO21 F-box protein 21 -2.0303