CRCGN015_MCF10A.WT.HP_24H:N15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cobalt sulfate heptahydrate 11.14 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:N15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 4.5775
CXCL2 chemokine (C-X-C motif) ligand 2 3.49319
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.14078
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.09994
WIF1 WNT inhibitory factor 1 3.03854
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.66853
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.52194
NUTF2 nuclear transport factor 2 2.51312
CNRIP1 cannabinoid receptor interacting protein 1 2.42346
SRSF6 serine/arginine-rich splicing factor 6 2.39906
AGR2 anterior gradient 2 2.36787
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.2378
KDM5A lysine (K)-specific demethylase 5A 2.23729
ANKRD10 ankyrin repeat domain 10 2.23524
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.20608
ARGLU1 arginine and glutamate rich 1 2.20368
WFS1 Wolfram syndrome 1 (wolframin) 2.16867
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.16015
ERCC5 excision repair cross-complementation group 5 2.12805
ACAA1 acetyl-CoA acyltransferase 1 2.11871
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.08882
CXCL3 chemokine (C-X-C motif) ligand 3 2.05933
BAG4 BCL2-associated athanogene 4 2.05177
CHEK1 checkpoint kinase 1 2.03284
PRPF39 pre-mRNA processing factor 39 2.00639

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.48011
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.45116
NVL nuclear VCP-like -3.42476
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.19671
HMG20B high mobility group 20B -3.15701
TENT4A terminal nucleotidyltransferase 4A -2.75631
KRT14 keratin 14, type I -2.71949
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.56727
STX4 syntaxin 4 -2.53037
DCK deoxycytidine kinase -2.49365
WASHC4 WASH complex subunit 4 -2.16563
SIL1 SIL1 nucleotide exchange factor -2.15852
TUBA4A tubulin, alpha 4a -2.11198
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.03226
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.03128