CRCGN015_MCF10A.WT.HP_24H:N18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-epoxybutane 10.81 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:N18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIF5C kinesin family member 5C 3.69221
HBA1 hemoglobin, alpha 1 3.55579
ADRB2 adrenoceptor beta 2, surface 3.18601
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.98901
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.91939
UBQLN2 ubiquilin 2 2.80084
SPAG4 sperm associated antigen 4 2.60309
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.46794
BZW2 basic leucine zipper and W2 domains 2 2.38733
LGMN legumain 2.35536
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.32843
ACAA1 acetyl-CoA acyltransferase 1 2.12741
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.06473
PLP1 proteolipid protein 1 2.04923

decreased expression

Symbol Name Standardized Value
ENOPH1 enolase-phosphatase 1 -6.43793
NPDC1 neural proliferation, differentiation and control, 1 -4.07852
CCNB1 cyclin B1 -3.59211
RNF167 ring finger protein 167 -3.51444
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.86972
CREB1 cAMP responsive element binding protein 1 -2.65662
MSN moesin -2.466
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.38809
FBXO21 F-box protein 21 -2.36753
RBM34 RNA binding motif protein 34 -2.08979
GADD45B growth arrest and DNA-damage-inducible, beta -2.07454
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I -2.00982