CRCGN015_MCF10A.WT.HP_24H:N21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.48413
COQ8A coenzyme Q8A 4.29762
MAP7 microtubule-associated protein 7 3.43828
STK10 serine/threonine kinase 10 3.19431
MCOLN1 mucolipin 1 3.17845
ADAM15 ADAM metallopeptidase domain 15 3.07928
CXCL2 chemokine (C-X-C motif) ligand 2 2.76189
C2CD2 C2 calcium-dependent domain containing 2 2.7577
MMP1 matrix metallopeptidase 1 2.71288
CERK ceramide kinase 2.70061
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.63978
EMID1 EMI domain containing 1 2.63652
PRR7 proline rich 7 (synaptic) 2.52585
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.42002
ACAA1 acetyl-CoA acyltransferase 1 2.35719
RAB3D RAB3D, member RAS oncogene family 2.33574
DCHS2 dachsous cadherin-related 2 2.33519
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.30069
HDAC11 histone deacetylase 11 2.26017
CD40LG CD40 ligand 2.2476
PRR11 proline rich 11 2.23858
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.22962
TZMP1 transition zone microprotein 1 2.22173
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.14332
LY6D lymphocyte antigen 6 complex, locus D 2.14249
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.13932
FCMR Fc fragment of IgM receptor 2.12989
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 2.09408
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.06883
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.06817
EPHX3 epoxide hydrolase 3 2.0666
PADI1 peptidyl arginine deiminase, type I 2.04319
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.03167
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.03002
THEM6 thioesterase superfamily member 6 2.02589
ADPRH ADP-ribosylarginine hydrolase 2.0195
CD244 CD244 molecule, natural killer cell receptor 2B4 2.00949
CCDC170 coiled-coil domain containing 170 2.00385

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -3.81027
CHMP4B charged multivesicular body protein 4B -3.71498
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.66488
NGRN neugrin, neurite outgrowth associated -3.59057
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.40869
VDAC1 voltage-dependent anion channel 1 -3.39057
TM9SF3 transmembrane 9 superfamily member 3 -3.30778
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.24426
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.20986
DNM1L dynamin 1-like -2.94334
HMG20B high mobility group 20B -2.88113
OXA1L oxidase (cytochrome c) assembly 1-like -2.68595
CETN2 centrin, EF-hand protein, 2 -2.64912
PCNA proliferating cell nuclear antigen -2.58647
FBXO7 F-box protein 7 -2.43835
SCYL3 SCY1-like 3 (S. cerevisiae) -2.41048
ACIN1 apoptotic chromatin condensation inducer 1 -2.24704
TIMP1 TIMP metallopeptidase inhibitor 1 -2.20673
NSFL1C NSFL1 (p97) cofactor (p47) -2.18707
IL4R interleukin 4 receptor -2.17096
SCMH1 sex comb on midleg homolog 1 (Drosophila) -2.15727
TBCB tubulin folding cofactor B -2.1049
MSN moesin -2.05163
MOK MOK protein kinase -2.04523
GARS1 glycyl-tRNA synthetase 1 -2.00976