CRCGN015_MCF10A.WT.HP_24H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenylephrine 33.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 3.9821
MINDY1 MINDY lysine 48 deubiquitinase 1 3.94927
SNAP25 synaptosomal-associated protein, 25kDa 3.74016
KLHL21 kelch-like family member 21 3.48365
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.38656
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.30776
MUC1 mucin 1, cell surface associated 2.93051
KDM5D lysine (K)-specific demethylase 5D 2.881
PDIA5 protein disulfide isomerase family A, member 5 2.78865
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.67541
GOLGA6L9 golgin A6 family-like 9 2.59432
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.4246
NOVA1 neuro-oncological ventral antigen 1 2.41017
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.38439
ITPKC inositol-trisphosphate 3-kinase C 2.37917
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.36431
SESN1 sestrin 1 2.362
TAGLN3 transgelin 3 2.35932
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.3206
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.30254
SATB1 SATB homeobox 1 2.29281
NSG2 neuronal vesicle trafficking associated 2 2.28072
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.23574
KLHDC8A kelch domain containing 8A 2.22563
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.22037
USP9Y ubiquitin specific peptidase 9, Y-linked 2.20169
CRYAB crystallin, alpha B 2.17484
RPH3A rabphilin 3A 2.17385
CATSPER2 cation channel, sperm associated 2 2.17214
RGS7 regulator of G-protein signaling 7 2.16134
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.15758
ANKRD10 ankyrin repeat domain 10 2.13561
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.13029
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.12914
PCDHGA8 protocadherin gamma subfamily A, 8 2.12414
NOTCH2NLB notch 2 N-terminal like B 2.11489
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.10355
MYO9A myosin IXA 2.10235
ABHD18 abhydrolase domain containing 18 2.09723
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.09596
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.09175
ABI3BP ABI family, member 3 (NESH) binding protein 2.06359
ANKRD36C ankyrin repeat domain 36C 2.06067
ARHGAP24 Rho GTPase activating protein 24 2.05713
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.05268
SCG3 secretogranin III 2.0217
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 2.02096
PCDHGA10 protocadherin gamma subfamily A, 10 2.01412

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.29189
THAP11 THAP domain containing 11 -4.37912
CCDC86 coiled-coil domain containing 86 -4.12771
PCCB propionyl CoA carboxylase, beta polypeptide -4.10821
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.68298
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.80646
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.60018
APIP APAF1 interacting protein -2.53674
NAT10 N-acetyltransferase 10 (GCN5-related) -2.53311
MSN moesin -2.53098
ZFPM1 zinc finger protein, FOG family member 1 -2.39508
KDM5C lysine (K)-specific demethylase 5C -2.30826
SCYL3 SCY1-like 3 (S. cerevisiae) -2.23507
SAC3D1 SAC3 domain containing 1 -2.22355
RNF167 ring finger protein 167 -2.21797
NUP62CL nucleoporin 62kDa C-terminal like -2.12603
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.11792
TRIM44 tripartite motif containing 44 -2.10856
SMC1A structural maintenance of chromosomes 1A -2.09554
SDCBP syndecan binding protein (syntenin) -2.07465
MOK MOK protein kinase -2.06371
USP9X ubiquitin specific peptidase 9, X-linked -2.0524
COMMD9 COMM domain containing 9 -2.04837
GTPBP6 GTP binding protein 6 (putative) -2.02942
PFN1 profilin 1 -2.0292
NUP93 nucleoporin 93kDa -2.02807