CRCGN015_MCF10A.WT.HP_24H:O01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 7.66925
KLHL21 kelch-like family member 21 5.52442
ABHD4 abhydrolase domain containing 4 4.82884
IGHMBP2 immunoglobulin mu binding protein 2 3.8474
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.23418
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 3.2103
HBA1 hemoglobin, alpha 1 3.18054
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.5573
TXNDC9 thioredoxin domain containing 9 2.44915
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.39502
NOL9 nucleolar protein 9 2.20222
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2.19819
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.18497
GET1 guided entry of tail-anchored proteins factor 1 2.17451
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 2.13923
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.13359
TBPL1 TBP-like 1 2.12826
CCNB2 cyclin B2 2.10697
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.09327
BRIX1 BRX1, biogenesis of ribosomes 2.0848
PLIN1 perilipin 1 2.08116
CLDN15 claudin 15 2.08106
RINT1 RAD50 interactor 1 2.05806
LBR lamin B receptor 2.05621
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.03845
ADAM10 ADAM metallopeptidase domain 10 2.01705
SSX2 synovial sarcoma, X breakpoint 2 2.01269
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.00533
CAV2 caveolin 2 2.00298
CNPY3 canopy FGF signaling regulator 3 2.00298

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.88261
KIF14 kinesin family member 14 -5.06257
MRPS2 mitochondrial ribosomal protein S2 -4.69718
CD81 CD81 molecule -4.17417
STXBP2 syntaxin binding protein 2 -4.13159
SEC16A SEC16 homolog A (S. cerevisiae) -3.89661
NISCH nischarin -3.79033
PPP1R26 protein phosphatase 1, regulatory subunit 26 -3.3102
UBAC1 UBA domain containing 1 -3.07164
FBXO21 F-box protein 21 -2.91646
COG7 component of oligomeric golgi complex 7 -2.91504
RALGDS ral guanine nucleotide dissociation stimulator -2.80565
NELFB negative elongation factor complex member B -2.60669
BRD3 bromodomain containing 3 -2.50019
TKT transketolase -2.49582
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.45126
EDF1 endothelial differentiation-related factor 1 -2.4355
ARID4B AT rich interactive domain 4B (RBP1-like) -2.42447
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.42389
PMPCA peptidase (mitochondrial processing) alpha -2.42192
ETFB electron-transfer-flavoprotein, beta polypeptide -2.3589
PRRC2B proline-rich coiled-coil 2B -2.33278
IRGQ immunity-related GTPase family, Q -2.32931
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.23651
RABAC1 Rab acceptor 1 (prenylated) -2.23543
ACOX2 acyl-CoA oxidase 2, branched chain -2.20087
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.13936
NOL4 nucleolar protein 4 -2.13016
TSPAN4 tetraspanin 4 -2.08857
MVP major vault protein -2.0575
PARP2 poly (ADP-ribose) polymerase 2 -2.04156
TYK2 tyrosine kinase 2 -2.03784
GABARAP GABA(A) receptor-associated protein -2.02536
BRD3OS BRD3 opposite strand -2.00797
RNPEP arginyl aminopeptidase (aminopeptidase B) -2.00621
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.00178