CRCGN015_MCF10A.WT.HP_24H:O02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

214 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.60102
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.89919
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.89728
EPHB2 EPH receptor B2 3.71911
RBBP9 retinoblastoma binding protein 9 3.2281
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.12088
PDLIM1 PDZ and LIM domain 1 3.00165
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.94405
EML4 echinoderm microtubule associated protein like 4 2.88376
KCTD20 potassium channel tetramerization domain containing 20 2.84594
GPR176 G protein-coupled receptor 176 2.84282
TFDP3 transcription factor Dp family, member 3 2.76949
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.6969
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase 2.68004
WDR4 WD repeat domain 4 2.67678
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.67064
LOC128966622 putative protein N-methyltransferase FAM86B2 2.56709
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.56295
PRAMEF26 PRAME family member 26 2.55011
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like 2.54383
DNAAF3 dynein, axonemal, assembly factor 3 2.53999
TDRD1 tudor domain containing 1 2.53653
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 2.51164
SCYL2 SCY1-like 2 (S. cerevisiae) 2.49932
WASHC5 WASH complex subunit 5 2.49182
ZNF623 zinc finger protein 623 2.48732
CHIT1 chitinase 1 (chitotriosidase) 2.48012
ADPRH ADP-ribosylarginine hydrolase 2.47691
GPR52 G protein-coupled receptor 52 2.43579
PROP1 PROP paired-like homeobox 1 2.43183
VPS26C VPS26 endosomal protein sorting factor C 2.4317
PKD2L1 polycystic kidney disease 2-like 1 2.43014
MCMBP minichromosome maintenance complex binding protein 2.4233
TNNI1 troponin I type 1 (skeletal, slow) 2.42101
PSG2 pregnancy specific beta-1-glycoprotein 2 2.41231
REV1 REV1, polymerase (DNA directed) 2.41053
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 2.40681
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.39709
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.39459
ZNF696 zinc finger protein 696 2.39127
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.3785
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.37384
GADD45A growth arrest and DNA-damage-inducible, alpha 2.355
LRRC40 leucine rich repeat containing 40 2.34116
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.33971
LGI1 leucine-rich, glioma inactivated 1 2.33772
ZNF74 zinc finger protein 74 2.33371
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.3326
MSRA methionine sulfoxide reductase A 2.32609
DCAF4 DDB1 and CUL4 associated factor 4 2.32353
BCAT1 branched chain amino-acid transaminase 1, cytosolic 2.32143
ZNF253 zinc finger protein 253 2.29345
EDA2R ectodysplasin A2 receptor 2.28558
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 2.2823
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.27986
MYZAP myocardial zonula adherens protein 2.27073
NTF3 neurotrophin 3 2.25288
ZFP30 ZFP30 zinc finger protein 2.24643
EFR3B EFR3 homolog B (S. cerevisiae) 2.24439
SSTR1 somatostatin receptor 1 2.24016
NIPAL2 NIPA-like domain containing 2 2.23154
MYNN myoneurin 2.22632
ETV3 ets variant 3 2.22517
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.22266
TMSB10 thymosin beta 10 2.22171
TMEM143 transmembrane protein 143 2.21988
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.21802
NCS1 neuronal calcium sensor 1 2.21779
GABPA GA binding protein transcription factor, alpha subunit 60kDa 2.21487
IPO8 importin 8 2.21102
R3HCC1L R3H domain and coiled-coil containing 1-like 2.20599
ENY2 enhancer of yellow 2 homolog (Drosophila) 2.20385
GPR88 G protein-coupled receptor 88 2.20356
MYL9 myosin, light chain 9, regulatory 2.20166
RPL3L ribosomal protein L3-like 2.19852
GOLGA6B golgin A6 family, member B 2.19759
RBM19 RNA binding motif protein 19 2.19415
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 2.19263
KITLG KIT ligand 2.18558
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.17783
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.17573
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.17512
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.17307
LINS1 lines homolog 1 2.16931
SCN5A sodium channel, voltage gated, type V alpha subunit 2.16621
ZNF778 zinc finger protein 778 2.16566
BTNL2 butyrophilin-like 2 2.16442
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 2.15918
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 2.15307
ATP8B4 ATPase, class I, type 8B, member 4 2.14338
ZNF318 zinc finger protein 318 2.13288
AQP6 aquaporin 6, kidney specific 2.13134
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.13108
RAD54L RAD54-like (S. cerevisiae) 2.12102
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.12
MTNR1A melatonin receptor 1A 2.11999
ERN1 endoplasmic reticulum to nucleus signaling 1 2.116
PDCD1LG2 programmed cell death 1 ligand 2 2.11561
AMELY amelogenin, Y-linked 2.11463
ZSCAN32 zinc finger and SCAN domain containing 32 2.11401
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 2.11247
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2.11208
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.10827
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.10711
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.10699
TMEM101 transmembrane protein 101 2.1038
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.10347
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.10314
MED31 mediator complex subunit 31 2.10301
PDE3A phosphodiesterase 3A, cGMP-inhibited 2.10284
CCL24 chemokine (C-C motif) ligand 24 2.09827
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2.09683
PSG3 pregnancy specific beta-1-glycoprotein 3 2.09527
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 2.09402
CCDC177 coiled-coil domain containing 177 2.09295
RNF146 ring finger protein 146 2.09135
KLF8 Kruppel-like factor 8 2.09101
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.0896
SSX5 synovial sarcoma, X breakpoint 5 2.08476
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.08343
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 2.08173
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.08066
OR51E2 olfactory receptor, family 51, subfamily E, member 2 2.07805
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.0775
LOC124900193 uncharacterized LOC124900193 2.07221
GNRH2 gonadotropin-releasing hormone 2 2.06753
PTPRJ protein tyrosine phosphatase, receptor type, J 2.06311
IL4 interleukin 4 2.06304
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.06002
FAM120C family with sequence similarity 120C 2.05695
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.05493
TRHR thyrotropin-releasing hormone receptor 2.05341
ZNF37A zinc finger protein 37A 2.05234
LATS1 large tumor suppressor kinase 1 2.05212
MAPK9 mitogen-activated protein kinase 9 2.0503
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.04792
MEN1 multiple endocrine neoplasia I 2.04755
JRK Jrk homolog (mouse) 2.04651
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.04569
MRPS18C mitochondrial ribosomal protein S18C 2.04528
HSF2BP heat shock transcription factor 2 binding protein 2.04399
LPAR3 lysophosphatidic acid receptor 3 2.04359
CLDN11 claudin 11 2.04246
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.04174
METTL8 methyltransferase like 8 2.04045
PMFBP1 polyamine modulated factor 1 binding protein 1 2.04041
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.0382
NEUROD2 neuronal differentiation 2 2.03779
KMT2D lysine (K)-specific methyltransferase 2D 2.03725
WNT3 wingless-type MMTV integration site family, member 3 2.03572
LRRC14 leucine rich repeat containing 14 2.03547
SP4 Sp4 transcription factor 2.0311
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 2.03032
FAM124B family with sequence similarity 124B 2.02925
EREG epiregulin 2.02768
PLPPR4 phospholipid phosphatase related 4 2.0273
RERGL RERG/RAS-like 2.02222
ZCCHC4 zinc finger, CCHC domain containing 4 2.02199
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.01443
ZNF804A zinc finger protein 804A 2.01418
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 2.00978
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.0093
PYCR3 pyrroline-5-carboxylate reductase 3 2.00861
KANSL3 KAT8 regulatory NSL complex subunit 3 2.00776
PSG6 pregnancy specific beta-1-glycoprotein 6 2.00696
ABRAXAS2 abraxas 2, BRISC complex subunit 2.00576
FGF23 fibroblast growth factor 23 2.00568
TMEM19 transmembrane protein 19 2.00227
COX7B cytochrome c oxidase subunit VIIb 2.00214

decreased expression

Symbol Name Standardized Value
RGS2 regulator of G-protein signaling 2 -5.74086
RNF167 ring finger protein 167 -5.10771
CHMP4B charged multivesicular body protein 4B -4.23499
CCNB1 cyclin B1 -3.9565
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.79264
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.75265
CD81 CD81 molecule -3.6679
STXBP2 syntaxin binding protein 2 -3.56562
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.38515
BASP1 brain abundant, membrane attached signal protein 1 -3.05565
ATF5 activating transcription factor 5 -3.02113
TCTA T-cell leukemia translocation altered -2.99646
LAP3 leucine aminopeptidase 3 -2.9357
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.87455
GDF15 growth differentiation factor 15 -2.84569
CREG1 cellular repressor of E1A-stimulated genes 1 -2.75449
CTNND1 catenin (cadherin-associated protein), delta 1 -2.74253
SLC67A1 solute carrier family 67 member 1 -2.72149
NPDC1 neural proliferation, differentiation and control, 1 -2.70767
UFM1 ubiquitin-fold modifier 1 -2.70759
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.64976
PCCB propionyl CoA carboxylase, beta polypeptide -2.59475
AP2M1 adaptor-related protein complex 2, mu 1 subunit -2.58003
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.51822
OGDHL oxoglutarate dehydrogenase-like -2.45448
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.44532
ETFB electron-transfer-flavoprotein, beta polypeptide -2.38969
NUDC nudC nuclear distribution protein -2.35923
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.35711
RTN3 reticulon 3 -2.31974
IFT88 intraflagellar transport 88 -2.29096
IRF7 interferon regulatory factor 7 -2.2497
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.18553
GMPPA GDP-mannose pyrophosphorylase A -2.16214
REEP5 receptor accessory protein 5 -2.15101
TIMP1 TIMP metallopeptidase inhibitor 1 -2.12622
DDRGK1 DDRGK domain containing 1 -2.07468
FXR2 fragile X mental retardation, autosomal homolog 2 -2.06424
SKIC2 SKI2 subunit of superkiller complex -2.05854
SEC13 SEC13 homolog (S. cerevisiae) -2.04985
NT5DC2 5'-nucleotidase domain containing 2 -2.0485
GABARAP GABA(A) receptor-associated protein -2.03923
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.03424
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.03175
RPH3AL rabphilin 3A-like (without C2 domains) -2.02924