CRCGN015_MCF10A.WT.HP_24H:O03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCEA2 transcription elongation factor A (SII), 2 3.93251
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.82936
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.67601
TSEN2 TSEN2 tRNA splicing endonuclease subunit 3.53912
ADAT1 adenosine deaminase, tRNA-specific 1 3.37418
HYOU1 hypoxia up-regulated 1 3.19669
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.57783
TBC1D15 TBC1 domain family, member 15 2.56401
METRN meteorin, glial cell differentiation regulator 2.55438
KATNBL1 katanin p80 subunit B-like 1 2.5463
KLHL21 kelch-like family member 21 2.52231
HBA1 hemoglobin, alpha 1 2.48561
BCAS2 breast carcinoma amplified sequence 2 2.47674
PRKCQ protein kinase C, theta 2.45157
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 2.39964
TOPBP1 topoisomerase (DNA) II binding protein 1 2.39539
PRAF2 PRA1 domain family, member 2 2.38234
TMEM109 transmembrane protein 109 2.34727
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 2.3345
FOS FBJ murine osteosarcoma viral oncogene homolog 2.30959
ZNF84 zinc finger protein 84 2.30625
ZNF74 zinc finger protein 74 2.25742
TXNL4B thioredoxin-like 4B 2.24793
BYSL bystin-like 2.23939
LY96 lymphocyte antigen 96 2.20489
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.19601
DNAAF5 dynein, axonemal, assembly factor 5 2.17907
TUBGCP4 tubulin, gamma complex associated protein 4 2.16449
PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.15857
NUP37 nucleoporin 37kDa 2.15516
TMEM50B transmembrane protein 50B 2.13793
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.13507
TMSB15C thymosin beta 15C 2.13047
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 2.09848
ANAPC10 anaphase promoting complex subunit 10 2.08581
MMP1 matrix metallopeptidase 1 2.08099
SMYD5 SMYD family member 5 2.05979
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.04462
NOPCHAP1 NOP protein chaperone 1 2.03405
HDAC9 histone deacetylase 9 2.02838
ARMC1 armadillo repeat containing 1 2.01775
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.01334
TBC1D31 TBC1 domain family, member 31 2.00372

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -5.04803
DSG2 desmoglein 2 -4.27141
PUF60 poly-U binding splicing factor 60KDa -3.90727
RNF167 ring finger protein 167 -3.6929
UFM1 ubiquitin-fold modifier 1 -3.16889
TRAPPC3 trafficking protein particle complex 3 -3.10662
ETFB electron-transfer-flavoprotein, beta polypeptide -3.02486
MSN moesin -2.92876
CD320 CD320 molecule -2.84439
PUM1 pumilio RNA-binding family member 1 -2.65433
ARID4B AT rich interactive domain 4B (RBP1-like) -2.45759
TYR tyrosinase -2.37118
DDB1 damage-specific DNA binding protein 1, 127kDa -2.34255
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -2.3341
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.32268
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.32249
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.32155
SPAG7 sperm associated antigen 7 -2.28792
TMUB2 transmembrane and ubiquitin-like domain containing 2 -2.26175
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.24846
CD81 CD81 molecule -2.23362
NT5DC2 5'-nucleotidase domain containing 2 -2.22223
GMPPA GDP-mannose pyrophosphorylase A -2.15062
CD151 CD151 molecule (Raph blood group) -2.1414
RBM47 RNA binding motif protein 47 -2.12816
CTSL cathepsin L -2.12485
VAT1 vesicle amine transport 1 -2.12296
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.11939
NISCH nischarin -2.1066
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.09588
HDAC1 histone deacetylase 1 -2.08747
MAGED2 melanoma antigen family D2 -2.07758
SNX17 sorting nexin 17 -2.06748
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.06679
HEATR1 HEAT repeat containing 1 -2.04664
ADAR adenosine deaminase, RNA-specific -2.04503
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.04114
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.01519
TXLNA taxilin alpha -2.01384
CDC16 cell division cycle 16 -2.00054