CRCGN015_MCF10A.WT.HP_24H:O05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FGFR4 fibroblast growth factor receptor 4 6.03849
WIF1 WNT inhibitory factor 1 4.1749
SPAG4 sperm associated antigen 4 3.36873
CARMIL1 capping protein regulator and myosin 1 linker 1 3.19356
MEF2C myocyte enhancer factor 2C 3.16234
UGT8 UDP glycosyltransferase 8 2.93555
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.78649
PRR7 proline rich 7 (synaptic) 2.76509
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.72722
NOTCH1 notch 1 2.63487
MAP7 microtubule-associated protein 7 2.60158
PLA2G15 phospholipase A2, group XV 2.58809
MBNL1 muscleblind-like splicing regulator 1 2.552
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 2.5413
DSCC1 DNA replication and sister chromatid cohesion 1 2.48723
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.48205
BAMBI BMP and activin membrane-bound inhibitor 2.46523
MPC1 mitochondrial pyruvate carrier 1 2.4455
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.41408
CTPS2 CTP synthase 2 2.38375
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.37527
MCM9 minichromosome maintenance complex component 9 2.3354
NKRF NFKB repressing factor 2.32481
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.32094
PDCL3 phosducin-like 3 2.30999
ACAA1 acetyl-CoA acyltransferase 1 2.29067
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.25
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 2.23019
PEX7 peroxisomal biogenesis factor 7 2.21602
TEX14 testis expressed 14 2.19756
ANO10 anoctamin 10 2.19069
HIPK3 homeodomain interacting protein kinase 3 2.12847
CCDC6 coiled-coil domain containing 6 2.12561
GOLT1B golgi transport 1B 2.12546
CD200 CD200 molecule 2.12069
PZP pregnancy-zone protein 2.08074
TBX2 T-box 2 2.07607
CLCN5 chloride channel, voltage-sensitive 5 2.07471
TMEM51 transmembrane protein 51 2.0697
RIDA reactive intermediate imine deaminase A homolog 2.05527
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.05142
FAR2 fatty acyl CoA reductase 2 2.04454
ZNF239 zinc finger protein 239 2.03605
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.02904
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.02139
YAF2 YY1 associated factor 2 2.00254

decreased expression

Symbol Name Standardized Value
UBE3C ubiquitin protein ligase E3C -4.1353
GDF15 growth differentiation factor 15 -4.00648
BASP1 brain abundant, membrane attached signal protein 1 -3.71571
RNF167 ring finger protein 167 -3.40417
PFN1 profilin 1 -3.40232
KIF20A kinesin family member 20A -3.39823
NGRN neugrin, neurite outgrowth associated -3.22113
CDC25B cell division cycle 25B -3.20381
MSMO1 methylsterol monooxygenase 1 -3.00966
WASHC4 WASH complex subunit 4 -2.99728
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.98749
CCNB1 cyclin B1 -2.97235
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.58882
CD58 CD58 molecule -2.58691
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.54232
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.45779
GREB1L growth regulation by estrogen in breast cancer-like -2.42731
ACADVL acyl-CoA dehydrogenase, very long chain -2.37697
ATG2A autophagy related 2A -2.3671
GLI3 GLI family zinc finger 3 -2.35369
PER3 period circadian clock 3 -2.35173
CD320 CD320 molecule -2.25096
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -2.2291
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.1621
IFRD2 interferon-related developmental regulator 2 -2.15704
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.14571
FAM3A family with sequence similarity 3, member A -2.09521
IL36G interleukin 36, gamma -2.08566
CENPO centromere protein O -2.0772
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.07701
TKT transketolase -2.05608
EXTL2 exostosin-like glycosyltransferase 2 -2.03768
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.03543
KCTD17 potassium channel tetramerization domain containing 17 -2.00946
CBX4 chromobox homolog 4 -2.00269