| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | indometacin 99.61 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
| Similar Terms | |
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145 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 6.2488 |
| GLRX | glutaredoxin (thioltransferase) | 5.20177 |
| TRIB3 | tribbles pseudokinase 3 | 4.3183 |
| WIF1 | WNT inhibitory factor 1 | 4.109 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 4.04046 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 4.01111 |
| PHGDH | phosphoglycerate dehydrogenase | 3.86893 |
| GATA2 | GATA binding protein 2 | 3.76883 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.71907 |
| PSAT1 | phosphoserine aminotransferase 1 | 3.70566 |
| ATF4 | activating transcription factor 4 | 3.6324 |
| WFS1 | Wolfram syndrome 1 (wolframin) | 3.50208 |
| AARS1 | alanyl-tRNA synthetase 1 | 3.38696 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 3.37901 |
| GARS1 | glycyl-tRNA synthetase 1 | 3.13885 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 3.13311 |
| KDM5A | lysine (K)-specific demethylase 5A | 3.0866 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 3.04337 |
| STXBP1 | syntaxin binding protein 1 | 3.02399 |
| SMIM40 | small integral membrane protein 40 | 3.00724 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 2.94814 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 2.88554 |
| TXNRD1 | thioredoxin reductase 1 | 2.8779 |
| LOC102724560 | cystathionine beta-synthase | 2.84624 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.83978 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.8285 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | 2.80855 |
| HMGA2 | high mobility group AT-hook 2 | 2.77443 |
| NUCB2 | nucleobindin 2 | 2.76928 |
| SARS1 | seryl-tRNA synthetase 1 | 2.7571 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 2.74512 |
| LAD1 | ladinin 1 | 2.74324 |
| TCTN1 | tectonic family member 1 | 2.73837 |
| GRB10 | growth factor receptor-bound protein 10 | 2.67853 |
| KIF5C | kinesin family member 5C | 2.64253 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 2.63455 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 2.60835 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 2.58094 |
| LOC128125814 | uncharacterized LOC128125814 | 2.55036 |
| GOLT1A | golgi transport 1A | 2.50675 |
| STX4 | syntaxin 4 | 2.45869 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 2.41837 |
| GATD3 | glutamine amidotransferase class 1 domain containing 3 | 2.41278 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | 2.34901 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 2.34884 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.33628 |
| LARP6 | La ribonucleoprotein domain family, member 6 | 2.32142 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.30956 |
| SQOR | sulfide quinone oxidoreductase | 2.26635 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 2.23376 |
| PFKL | phosphofructokinase, liver | 2.21087 |
| RBP4 | retinol binding protein 4, plasma | 2.20603 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 2.20439 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 2.18311 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | 2.16258 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 2.15692 |
| MAVS | mitochondrial antiviral signaling protein | 2.15146 |
| VGLL4 | vestigial-like family member 4 | 2.13357 |
| USO1 | USO1 vesicle transport factor | 2.10944 |
| IFRD1 | interferon-related developmental regulator 1 | 2.10916 |
| GTPBP2 | GTP binding protein 2 | 2.10615 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 2.08727 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 2.08122 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 2.07736 |
| UNC5B | unc-5 homolog B (C. elegans) | 2.07463 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | 2.07246 |
| MSRA | methionine sulfoxide reductase A | 2.05535 |
| STC2 | stanniocalcin 2 | 2.05409 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | 2.03785 |
| ELP3 | elongator acetyltransferase complex subunit 3 | 2.02634 |
| TARS1 | threonyl-tRNA synthetase 1 | 2.0251 |
| CHMP4B | charged multivesicular body protein 4B | 2.01958 |
| VEGFA | vascular endothelial growth factor A | 2.01946 |
| LMBRD1 | LMBR1 domain containing 1 | 2.01593 |
| Symbol | Name | Standardized Value |
|---|---|---|
| STMN1 | stathmin 1 | -4.83729 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -4.68392 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -4.6011 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -4.56049 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -4.45432 |
| PUF60 | poly-U binding splicing factor 60KDa | -4.23396 |
| PARP1 | poly (ADP-ribose) polymerase 1 | -3.96914 |
| HMG20B | high mobility group 20B | -3.94797 |
| CD320 | CD320 molecule | -3.82451 |
| CCNB2 | cyclin B2 | -3.80722 |
| DCK | deoxycytidine kinase | -3.80447 |
| CD81 | CD81 molecule | -3.47735 |
| CBR3 | carbonyl reductase 3 | -3.46373 |
| HOXA5 | homeobox A5 | -3.36678 |
| MRPL12 | mitochondrial ribosomal protein L12 | -3.20332 |
| BIRC5 | baculoviral IAP repeat containing 5 | -3.13317 |
| KIF20A | kinesin family member 20A | -3.0412 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -3.0093 |
| SESN1 | sestrin 1 | -2.95727 |
| ASF1B | anti-silencing function 1B histone chaperone | -2.67898 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | -2.66541 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.57324 |
| CDK1 | cyclin-dependent kinase 1 | -2.57277 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.57082 |
| CCNA2 | cyclin A2 | -2.54003 |
| NUP93 | nucleoporin 93kDa | -2.53543 |
| MCM3 | minichromosome maintenance complex component 3 | -2.51635 |
| AURKB | aurora kinase B | -2.4656 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.40043 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -2.39103 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.37935 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -2.37722 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.37671 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -2.36689 |
| C1QBP | complement component 1, q subcomponent binding protein | -2.36589 |
| PMF1-BGLAP | PMF1-BGLAP readthrough | -2.35368 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.34533 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -2.32763 |
| FEN1 | flap structure-specific endonuclease 1 | -2.29279 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -2.28569 |
| TMEM109 | transmembrane protein 109 | -2.28371 |
| RPA3 | replication protein A3, 14kDa | -2.28203 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -2.26244 |
| PIMREG | PICALM interacting mitotic regulator | -2.25846 |
| TAC4 | tachykinin 4 (hemokinin) | -2.24393 |
| SNRNP25 | small nuclear ribonucleoprotein 25kDa (U11/U12) | -2.2077 |
| MARCKSL1 | MARCKS-like 1 | -2.17093 |
| ANAPC15 | anaphase promoting complex subunit 15 | -2.16827 |
| TDRD7 | tudor domain containing 7 | -2.14356 |
| FZD2 | frizzled class receptor 2 | -2.14306 |
| HDAC3 | histone deacetylase 3 | -2.14261 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.13992 |
| STXBP2 | syntaxin binding protein 2 | -2.13839 |
| AURKA | aurora kinase A | -2.13733 |
| PRR15L | proline rich 15-like | -2.1361 |
| MTA2 | metastasis associated 1 family, member 2 | -2.13022 |
| BID | BH3 interacting domain death agonist | -2.1232 |
| HSPB1 | heat shock 27kDa protein 1 | -2.1192 |
| WRAP53 | WD repeat containing, antisense to TP53 | -2.11463 |
| NDUFS3 | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) | -2.08565 |
| CCN5 | cellular communication network factor 5 | -2.07716 |
| CCNB1 | cyclin B1 | -2.07636 |
| NUP85 | nucleoporin 85kDa | -2.04354 |
| COL4A1 | collagen, type IV, alpha 1 | -2.03045 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | -2.02894 |
| CDK4 | cyclin-dependent kinase 4 | -2.02511 |
| HDAC2 | histone deacetylase 2 | -2.01777 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.01721 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -2.01531 |
| HMGB3 | high mobility group box 3 | -2.01277 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -2.00306 |
