CRCGN015_MCF10A.WT.HP_24H:O08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indometacin 33.2 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

126 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.24418
TLR4 toll-like receptor 4 4.2667
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.67632
CIAO3 cytosolic iron-sulfur assembly component 3 3.63046
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.96433
TBX2 T-box 2 2.69253
ADAM17 ADAM metallopeptidase domain 17 2.66365
CYBB cytochrome b-245, beta polypeptide 2.62182
SQOR sulfide quinone oxidoreductase 2.55849
SMAD2 SMAD family member 2 2.55586
C5AR1 complement component 5a receptor 1 2.55432
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.51935
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.50138
MDM4 MDM4, p53 regulator 2.49956
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.45002
AGO4 argonaute RISC catalytic component 4 2.38933
TOR1A torsin family 1, member A (torsin A) 2.37088
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.36191
AGPS alkylglycerone phosphate synthase 2.34043
FKBP5 FK506 binding protein 5 2.32542
RIPOR1 RHO family interacting cell polarization regulator 1 2.31865
UCKL1 uridine-cytidine kinase 1-like 1 2.30878
MAPK14 mitogen-activated protein kinase 14 2.3017
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.30007
WDFY3 WD repeat and FYVE domain containing 3 2.2822
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.27379
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.27321
AZU1 azurocidin 1 2.26859
PCNX1 pecanex 1 2.26813
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 2.26806
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.26036
HP1BP3 heterochromatin protein 1, binding protein 3 2.25708
HMOX1 heme oxygenase 1 2.24854
TCN2 transcobalamin II 2.24438
STK17B serine/threonine kinase 17b 2.24056
FXYD2 FXYD domain containing ion transport regulator 2 2.21749
SH2D1A SH2 domain containing 1A 2.18505
MOB1A MOB kinase activator 1A 2.17565
RAB28 RAB28, member RAS oncogene family 2.17354
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.16499
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.16402
ZNF451 zinc finger protein 451 2.16341
PILRA paired immunoglobin-like type 2 receptor alpha 2.1615
RBBP8 retinoblastoma binding protein 8 2.15596
TWSG1 twisted gastrulation BMP signaling modulator 1 2.15571
IRAK3 interleukin-1 receptor-associated kinase 3 2.15334
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 2.15229
CCR1 chemokine (C-C motif) receptor 1 2.14598
SCCPDH saccharopine dehydrogenase (putative) 2.1334
THRAP3 thyroid hormone receptor associated protein 3 2.1176
VCAN versican 2.11708
NCF2 neutrophil cytosolic factor 2 2.11338
PKN1 protein kinase N1 2.11324
BCCIP BRCA2 and CDKN1A interacting protein 2.11147
CFP complement factor properdin 2.0964
CRLF3 cytokine receptor-like factor 3 2.09005
PLXDC2 plexin domain containing 2 2.08398
OSTF1 osteoclast stimulating factor 1 2.07459
CLEC11A C-type lectin domain family 11, member A 2.07102
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.06435
ADA2 adenosine deaminase 2 2.06102
ATP8B4 ATPase, class I, type 8B, member 4 2.05203
DENND2D DENN/MADD domain containing 2D 2.05047
GGNBP2 gametogenetin binding protein 2 2.04354
TLR2 toll-like receptor 2 2.04146
TLR8 toll-like receptor 8 2.03678
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.03206
CUEDC2 CUE domain containing 2 2.02233
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.02009
MAP3K2 mitogen-activated protein kinase kinase kinase 2 2.0176
POU4F1 POU class 4 homeobox 1 2.01355
OLFML2B olfactomedin-like 2B 2.00076

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.88291
NPDC1 neural proliferation, differentiation and control, 1 -5.0672
PPIC peptidylprolyl isomerase C (cyclophilin C) -4.37163
HSPA8 heat shock 70kDa protein 8 -4.2469
TES testin LIM domain protein -4.10511
TIMP1 TIMP metallopeptidase inhibitor 1 -3.4854
UFM1 ubiquitin-fold modifier 1 -3.4506
TUBA4A tubulin, alpha 4a -3.32633
CREG1 cellular repressor of E1A-stimulated genes 1 -3.25525
CANT1 calcium activated nucleotidase 1 -3.01045
CAB39 calcium binding protein 39 -2.99388
HOXB13 homeobox B13 -2.99205
CDC37 cell division cycle 37 -2.86772
SDF4 stromal cell derived factor 4 -2.71575
SCYL3 SCY1-like 3 (S. cerevisiae) -2.65039
ABHD17A abhydrolase domain containing 17A -2.62086
SEC24C SEC24 family member C -2.60903
GDF15 growth differentiation factor 15 -2.53701
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -2.48742
ATAD3A ATPase family, AAA domain containing 3A -2.44221
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.31892
RASL12 RAS-like, family 12 -2.30746
RCC1L RCC1 like -2.28896
LMO1 LIM domain only 1 (rhombotin 1) -2.27681
CCDC86 coiled-coil domain containing 86 -2.27444
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -2.26348
TSC22D1 TSC22 domain family, member 1 -2.25163
BRMS1L breast cancer metastasis-suppressor 1-like -2.25079
HOXC13 homeobox C13 -2.22974
CDC34 cell division cycle 34 -2.22097
FAM110D family with sequence similarity 110, member D -2.21917
HMG20B high mobility group 20B -2.20065
PRCP prolylcarboxypeptidase (angiotensinase C) -2.17884
SOD3 superoxide dismutase 3, extracellular -2.17579
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.16536
FAM8A1 family with sequence similarity 8, member A1 -2.16506
PFN1 profilin 1 -2.15277
ZNF593 zinc finger protein 593 -2.11391
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.11108
BST2 bone marrow stromal cell antigen 2 -2.10784
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.10644
MED15 mediator complex subunit 15 -2.09848
SELE selectin E -2.07193
PLCD1 phospholipase C, delta 1 -2.06001
HMOX2 heme oxygenase 2 -2.05238
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -2.04462
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.04324
KRT14 keratin 14, type I -2.03734
MYDGF myeloid-derived growth factor -2.02965
LMO3 LIM domain only 3 (rhombotin-like 2) -2.02308
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.01194
METTL22 methyltransferase like 22 -2.00679
DLK1 delta-like 1 homolog (Drosophila) -2.00458
SNAP29 synaptosomal-associated protein, 29kDa -2.00093