CRCGN015_MCF10A.WT.HP_24H:O09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indometacin 11.07 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADAM10 ADAM metallopeptidase domain 10 5.00293
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.5299
UBQLN2 ubiquilin 2 4.0689
PNKP polynucleotide kinase 3'-phosphatase 3.30682
FBXL12 F-box and leucine-rich repeat protein 12 3.05063
CNPY3 canopy FGF signaling regulator 3 2.65357
RTN2 reticulon 2 2.50875
CENPE centromere protein E, 312kDa 2.43665
ZFAND1 zinc finger, AN1-type domain 1 2.4248
BORA bora, aurora kinase A activator 2.36144
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.22964
STAU2 staufen double-stranded RNA binding protein 2 2.19598
COL11A1 collagen, type XI, alpha 1 2.18807
MOCS3 molybdenum cofactor synthesis 3 2.17954
USP3 ubiquitin specific peptidase 3 2.17839
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.15827
LIN9 lin-9 DREAM MuvB core complex component 2.10056
FBP1 fructose-1,6-bisphosphatase 1 2.0821
NCK1 NCK adaptor protein 1 2.07244
MYZAP myocardial zonula adherens protein 2.03851
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.02292
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.01801
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.01549

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.04362
PCNA proliferating cell nuclear antigen -4.88755
CD81 CD81 molecule -4.36811
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.30639
SCYL3 SCY1-like 3 (S. cerevisiae) -3.41382
CRTAP cartilage associated protein -2.69332
MRPL12 mitochondrial ribosomal protein L12 -2.52482
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.49075
TNIP1 TNFAIP3 interacting protein 1 -2.2494
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -2.23728
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.20104
CD320 CD320 molecule -2.19093
PRDX4 peroxiredoxin 4 -2.16036
DENR density-regulated protein -2.15179
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.1152
MAP2K2 mitogen-activated protein kinase kinase 2 -2.06599
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.02755
LRP10 low density lipoprotein receptor-related protein 10 -2.01287