CRCGN015_MCF10A.WT.HP_24H:O13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description catechol 98.9 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

112 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 6.04151
AGR2 anterior gradient 2 4.5635
WIF1 WNT inhibitory factor 1 4.359
SNAP25 synaptosomal-associated protein, 25kDa 4.28219
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.96427
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.625
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.05798
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.92031
CCDC92 coiled-coil domain containing 92 2.90731
STMN2 stathmin 2 2.84608
VGLL4 vestigial-like family member 4 2.81194
IFT81 intraflagellar transport 81 2.8006
OLFML3 olfactomedin-like 3 2.7492
MUC4 mucin 4, cell surface associated 2.68568
MEF2C myocyte enhancer factor 2C 2.50573
TBPL1 TBP-like 1 2.50313
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.48895
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 2.47136
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.46353
PFN2 profilin 2 2.38772
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.38609
CCNJ cyclin J 2.37173
CD248 CD248 molecule, endosialin 2.36997
NLRP2 NLR family, pyrin domain containing 2 2.34251
LRRC49 leucine rich repeat containing 49 2.32158
SMN2 survival of motor neuron 2, centromeric 2.31126
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.25744
CCNL1 cyclin L1 2.24642
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.24197
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 2.22885
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.22365
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.21396
CEP192 centrosomal protein 192kDa 2.18825
IRF6 interferon regulatory factor 6 2.16291
OSR2 odd-skipped related transciption factor 2 2.14259
E2F5 E2F transcription factor 5, p130-binding 2.13703
PDCL3 phosducin-like 3 2.09263
H2AX H2A.X variant histone 2.08522
NEFL neurofilament, light polypeptide 2.07296
EFHD1 EF-hand domain family, member D1 2.06852
NKRF NFKB repressing factor 2.06733
USP39 ubiquitin specific peptidase 39 2.05037
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.04516
IFT52 intraflagellar transport 52 2.02625
AP1AR adaptor-related protein complex 1 associated regulatory protein 2.02444
NXT2 nuclear transport factor 2-like export factor 2 2.02381
VSNL1 visinin-like 1 2.02119
LGMN legumain 2.0143
DVL3 dishevelled segment polarity protein 3 2.01191
TMSB15C thymosin beta 15C 2.00686
CRABP1 cellular retinoic acid binding protein 1 2.00241
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.00007

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -7.26605
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -7.13594
NUP85 nucleoporin 85kDa -4.61659
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.27428
GOLT1B golgi transport 1B -4.18663
MRPS7 mitochondrial ribosomal protein S7 -3.81295
MRPL58 mitochondrial ribosomal protein L58 -3.74597
TIMP1 TIMP metallopeptidase inhibitor 1 -3.60055
VDAC1 voltage-dependent anion channel 1 -3.59185
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.32539
ARID4B AT rich interactive domain 4B (RBP1-like) -3.26702
ACOX1 acyl-CoA oxidase 1, palmitoyl -3.13611
SAP30BP SAP30 binding protein -3.06471
TMEM115 transmembrane protein 115 -3.03345
JTB jumping translocation breakpoint -2.96252
FBXO7 F-box protein 7 -2.9213
GALK1 galactokinase 1 -2.85014
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.80107
KCTD2 potassium channel tetramerization domain containing 2 -2.77135
ZNF672 zinc finger protein 672 -2.73575
CASKIN2 CASK interacting protein 2 -2.56982
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.5689
TKT transketolase -2.54264
TMEM94 transmembrane protein 94 -2.50668
DTD1 D-tyrosyl-tRNA deacylase 1 -2.50424
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.49641
IFRD2 interferon-related developmental regulator 2 -2.45886
RBM34 RNA binding motif protein 34 -2.42415
RTRAF RNA transcription, translation and transport factor -2.36914
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.33742
FKBP10 FK506 binding protein 10, 65 kDa -2.33013
CDR2L cerebellar degeneration-related protein 2-like -2.3292
ZNF430 zinc finger protein 430 -2.32546
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.28894
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.26971
GMPPA GDP-mannose pyrophosphorylase A -2.26939
GGPS1 geranylgeranyl diphosphate synthase 1 -2.25564
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.25396
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.24801
KYAT1 kynurenine aminotransferase 1 -2.24544
WBP2 WW domain binding protein 2 -2.23366
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.20632
YME1L1 YME1-like 1 ATPase -2.189
HLA-C major histocompatibility complex, class I, C -2.17956
ZNF282 zinc finger protein 282 -2.15093
HAX1 HCLS1 associated protein X-1 -2.13681
SFI1 Sfi1 homolog, spindle assembly associated (yeast) -2.12946
PMPCA peptidase (mitochondrial processing) alpha -2.12765
LIPG lipase, endothelial -2.11375
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.09086
SEC14L2 SEC14-like 2 (S. cerevisiae) -2.08705
FBXO21 F-box protein 21 -2.06789
HLA-G major histocompatibility complex, class I, G -2.06481
ERGIC2 ERGIC and golgi 2 -2.03622
SUMO4 small ubiquitin-like modifier 4 -2.01675
LOC128031832 uncharacterized LOC128031832 -2.01235
H1-0 H1.0 linker histone -2.00699
TPRA1 transmembrane protein, adipocyte asscociated 1 -2.00441
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -2.00378
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.00359