CRCGN015_MCF10A.WT.HP_24H:O18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-nitroacenaphthene 10.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 6.05617
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.3281
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.12347
CNRIP1 cannabinoid receptor interacting protein 1 3.05763
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.79859
WNT2 wingless-type MMTV integration site family member 2 2.66983
MAST2 microtubule associated serine/threonine kinase 2 2.65764
ZNF589 zinc finger protein 589 2.46168
ZNF586 zinc finger protein 586 2.43853
ZNF276 zinc finger protein 276 2.43313
NISCH nischarin 2.40088
CA14 carbonic anhydrase XIV 2.3466
FBLN5 fibulin 5 2.31155
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.28421
ZNF85 zinc finger protein 85 2.26446
OCA2 oculocutaneous albinism II 2.24424
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.22604
GOLGA6L9 golgin A6 family-like 9 2.18237
KLHDC8A kelch domain containing 8A 2.16193
RLF rearranged L-myc fusion 2.13766
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 2.13685
SOX10 SRY (sex determining region Y)-box 10 2.13052
ENOSF1 enolase superfamily member 1 2.11182
TRIM24 tripartite motif containing 24 2.10002
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.0795
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 2.07335
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.05833
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.05743
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 2.03919
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.03013
CATSPER2 cation channel, sperm associated 2 2.0275
TMEM187 transmembrane protein 187 2.02408
FOXL2 forkhead box L2 2.01404
ZNF778 zinc finger protein 778 2.00179

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.43378
MSMO1 methylsterol monooxygenase 1 -3.23427
ENOPH1 enolase-phosphatase 1 -2.72291
HSPA4 heat shock 70kDa protein 4 -2.67801
ELAC2 elaC ribonuclease Z 2 -2.54932
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.50566
STXBP2 syntaxin binding protein 2 -2.45692
CANT1 calcium activated nucleotidase 1 -2.4357
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.42093
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.34779
PLVAP plasmalemma vesicle associated protein -2.31549
PFN1 profilin 1 -2.19057
SQSTM1 sequestosome 1 -2.11273
MSRA methionine sulfoxide reductase A -2.08394