CRCGN015_MCF10A.WT.HP_24H:O19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfallate 100.72 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 4.21297
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.91402
WIF1 WNT inhibitory factor 1 3.7565
PDLIM1 PDZ and LIM domain 1 3.39765
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.24915
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.94379
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.86917
WFS1 Wolfram syndrome 1 (wolframin) 2.85425
TXNL4B thioredoxin-like 4B 2.68831
ACAA1 acetyl-CoA acyltransferase 1 2.68002
H2BC21 H2B clustered histone 21 2.63455
ZBED5 zinc finger, BED-type containing 5 2.56538
CNRIP1 cannabinoid receptor interacting protein 1 2.52485
HPR haptoglobin-related protein 2.44357
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.42989
CPB2 carboxypeptidase B2 (plasma) 2.28144
TSPAN6 tetraspanin 6 2.264
TFDP3 transcription factor Dp family, member 3 2.25359
SLC38A2 solute carrier family 38, member 2 2.25243
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.24903
PEX2 peroxisomal biogenesis factor 2 2.24364
ZFAND1 zinc finger, AN1-type domain 1 2.21
HPD 4-hydroxyphenylpyruvate dioxygenase 2.1933
TOPBP1 topoisomerase (DNA) II binding protein 1 2.19109
RPP38 ribonuclease P/MRP 38kDa subunit 2.1749
CCL7 chemokine (C-C motif) ligand 7 2.16809
FBXL12 F-box and leucine-rich repeat protein 12 2.16808
HPS6 Hermansky-Pudlak syndrome 6 2.15718
SNX3 sorting nexin 3 2.14848
TPSG1 tryptase gamma 1 2.1308
ATG5 autophagy related 5 2.09795
DCPH1 damage control phosphatase 1 2.07758
SDF2 stromal cell-derived factor 2 2.05788
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.05707
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 2.05273
ZZZ3 zinc finger, ZZ-type containing 3 2.04908
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.04814
BET1 Bet1 golgi vesicular membrane trafficking protein 2.04289
NCK1 NCK adaptor protein 1 2.02924
SESN1 sestrin 1 2.02871
CADM1 cell adhesion molecule 1 2.02848
ZNF862 zinc finger protein 862 2.02376
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.01582
TMSB15C thymosin beta 15C 2.01541
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.00723
KAT6B K(lysine) acetyltransferase 6B 2.00624

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -6.33952
CAB39 calcium binding protein 39 -5.35852
VDAC1 voltage-dependent anion channel 1 -4.87846
BASP1 brain abundant, membrane attached signal protein 1 -4.25448
CCDC86 coiled-coil domain containing 86 -4.06807
NPDC1 neural proliferation, differentiation and control, 1 -3.82067
TIMP1 TIMP metallopeptidase inhibitor 1 -3.40835
STXBP2 syntaxin binding protein 2 -3.29794
PRPF4 pre-mRNA processing factor 4 -3.29438
CCNB2 cyclin B2 -3.07241
PPIE peptidylprolyl isomerase E (cyclophilin E) -3.02123
PARP2 poly (ADP-ribose) polymerase 2 -2.97849
ANXA2 annexin A2 -2.86758
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.79315
KEAP1 kelch-like ECH-associated protein 1 -2.73014
CANT1 calcium activated nucleotidase 1 -2.58079
PFN1 profilin 1 -2.58073
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.47893
EXOSC4 exosome component 4 -2.41433
TXLNA taxilin alpha -2.34307
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.33919
STK25 serine/threonine kinase 25 -2.31962
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.31121
MSN moesin -2.27362
PARP1 poly (ADP-ribose) polymerase 1 -2.26562
NUDC nudC nuclear distribution protein -2.24063
TATDN2 TatD DNase domain containing 2 -2.23769
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.22567
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.16738
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.15788
SCYL3 SCY1-like 3 (S. cerevisiae) -2.08759
ELAC2 elaC ribonuclease Z 2 -2.08743
KRT14 keratin 14, type I -2.08241
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.07107
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.05726
SSRP1 structure specific recognition protein 1 -2.03957
GARS1 glycyl-tRNA synthetase 1 -2.0372
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -2.02869
REEP4 receptor accessory protein 4 -2.0207
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.00884
MRPS2 mitochondrial ribosomal protein S2 -2.00569
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.0041