CRCGN015_MCF10A.WT.HP_24H:O22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetamide 105.01 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:O22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 4.05704
ADGRE5 adhesion G protein-coupled receptor E5 3.79415
PPARG peroxisome proliferator-activated receptor gamma 3.66482
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.56117
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.47126
STK10 serine/threonine kinase 10 2.9626
GPER1 G protein-coupled estrogen receptor 1 2.93909
TIAM1 T-cell lymphoma invasion and metastasis 1 2.76499
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.72326
HBA1 hemoglobin, alpha 1 2.69457
RIDA reactive intermediate imine deaminase A homolog 2.61372
ANKRD49 ankyrin repeat domain 49 2.50967
WFS1 Wolfram syndrome 1 (wolframin) 2.34872
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.28533
ZFAND1 zinc finger, AN1-type domain 1 2.27867
HBB hemoglobin, beta 2.26871
VAV3 vav 3 guanine nucleotide exchange factor 2.26149
ASDURF ASNSD1 upstream open reading frame 2.24855
PEX2 peroxisomal biogenesis factor 2 2.24278
TXNL4B thioredoxin-like 4B 2.23121
HSPA14 heat shock 70kDa protein 14 2.22899
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.22744
MTMR6 myotubularin related protein 6 2.16132
ASB7 ankyrin repeat and SOCS box containing 7 2.15842
CRYZ crystallin, zeta (quinone reductase) 2.15611
TMEM126B transmembrane protein 126B 2.11278
RPP38 ribonuclease P/MRP 38kDa subunit 2.07822
MTERF3 mitochondrial transcription termination factor 3 2.06037
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.0552
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine 2.04946
DENND2D DENN/MADD domain containing 2D 2.02054
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 2.01916
ATG5 autophagy related 5 2.00116

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -5.0854
BASP1 brain abundant, membrane attached signal protein 1 -4.4896
STXBP2 syntaxin binding protein 2 -3.6409
HMG20B high mobility group 20B -3.56962
DSG2 desmoglein 2 -3.56132
TXLNA taxilin alpha -3.38089
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.23001
PCNA proliferating cell nuclear antigen -3.17807
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.87057
PANK2 pantothenate kinase 2 -2.84352
TAC4 tachykinin 4 (hemokinin) -2.82248
ARID4B AT rich interactive domain 4B (RBP1-like) -2.73877
TUBA4A tubulin, alpha 4a -2.50844
ISOC1 isochorismatase domain containing 1 -2.4943
MSN moesin -2.4642
DDRGK1 DDRGK domain containing 1 -2.37806
PFN1 profilin 1 -2.37618
TUBB4B tubulin, beta 4B class IVb -2.31045
SQSTM1 sequestosome 1 -2.23887
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.2206
NUDC nudC nuclear distribution protein -2.21804
CCDC22 coiled-coil domain containing 22 -2.14251
UBA1 ubiquitin-like modifier activating enzyme 1 -2.13699
VDAC1 voltage-dependent anion channel 1 -2.10464
TKT transketolase -2.10427
PNPLA6 patatin-like phospholipase domain containing 6 -2.09189
CHD8 chromodomain helicase DNA binding protein 8 -2.03404
ASCC2 activating signal cointegrator 1 complex subunit 2 -2.0325
KEAP1 kelch-like ECH-associated protein 1 -2.03101
CBR3 carbonyl reductase 3 -2.00133