CRCGN015_MCF10A.WT.HP_24H:P01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acedapsone 98.29 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 3.41497
SNAP25 synaptosomal-associated protein, 25kDa 3.35757
CCL2 chemokine (C-C motif) ligand 2 3.1877
SKIC2 SKI2 subunit of superkiller complex 3.11343
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.85031
NSG2 neuronal vesicle trafficking associated 2 2.83311
RPP38 ribonuclease P/MRP 38kDa subunit 2.79252
STMN2 stathmin 2 2.57718
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.53884
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.35503
DGKD diacylglycerol kinase, delta 130kDa 2.33714
S100A4 S100 calcium binding protein A4 2.33482
LSR lipolysis stimulated lipoprotein receptor 2.13472
SLC35F2 solute carrier family 35, member F2 2.129
PRR7 proline rich 7 (synaptic) 2.01707
LAMB1 laminin, beta 1 2.00966

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -4.64988
COG7 component of oligomeric golgi complex 7 -4.5219
BASP1 brain abundant, membrane attached signal protein 1 -3.97903
COG2 component of oligomeric golgi complex 2 -3.6012
SGK1 serum/glucocorticoid regulated kinase 1 -3.2188
ZNF274 zinc finger protein 274 -3.18948
COPS7A COP9 signalosome subunit 7A -3.04615
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -2.98638
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.75662
KDM3A lysine (K)-specific demethylase 3A -2.64033
RNF167 ring finger protein 167 -2.631
TCTA T-cell leukemia translocation altered -2.61375
YME1L1 YME1-like 1 ATPase -2.61231
ZSCAN18 zinc finger and SCAN domain containing 18 -2.50896
STXBP2 syntaxin binding protein 2 -2.50809
PFN1 profilin 1 -2.49359
GABARAP GABA(A) receptor-associated protein -2.47784
PRKCQ protein kinase C, theta -2.47639
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 -2.41573
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.40048
CORO1A coronin, actin binding protein, 1A -2.31967
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.30736
TOX thymocyte selection-associated high mobility group box -2.30225
TLR4 toll-like receptor 4 -2.29465
FPR2 formyl peptide receptor 2 -2.28778
PTPRK protein tyrosine phosphatase, receptor type, K -2.26522
SYNGR3 synaptogyrin 3 -2.2395
CTSD cathepsin D -2.2243
MICU1 mitochondrial calcium uptake 1 -2.22089
KLK11 kallikrein-related peptidase 11 -2.19628
GJA1 gap junction protein, alpha 1, 43kDa -2.18419
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.1779
SOAT2 sterol O-acyltransferase 2 -2.15745
LSP1 lymphocyte-specific protein 1 -2.1337
ADAT1 adenosine deaminase, tRNA-specific 1 -2.11094
KIFBP kinesin family binding protein -2.10762
TBX2 T-box 2 -2.10548
KRT6B keratin 6B, type II -2.08154
GMPPB GDP-mannose pyrophosphorylase B -2.07058
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.05907
KRT15 keratin 15, type I -2.05001
FZD7 frizzled class receptor 7 -2.04496
TCEAL4 transcription elongation factor A (SII)-like 4 -2.03905
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -2.00642
MSN moesin -2.00303