CRCGN015_MCF10A.WT.HP_24H:P03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acedapsone 10.92 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

171 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MCOLN1 mucolipin 1 4.81831
SNAP25 synaptosomal-associated protein, 25kDa 4.70659
UBQLN2 ubiquilin 2 4.54693
ZW10 zw10 kinetochore protein 4.27685
INTS3 integrator complex subunit 3 4.1994
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.93831
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.85474
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 3.4217
RUNDC3A RUN domain containing 3A 3.18127
HLA-DRA major histocompatibility complex, class II, DR alpha 3.10331
NSG2 neuronal vesicle trafficking associated 2 3.07427
RTN2 reticulon 2 3.07245
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.95551
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2.9253
SYN1 synapsin I 2.89124
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.8802
STMN2 stathmin 2 2.87763
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.81193
KLHDC2 kelch domain containing 2 2.76817
TWIST1 twist family bHLH transcription factor 1 2.7447
THOC1 THO complex 1 2.70473
SV2B synaptic vesicle glycoprotein 2B 2.69413
ZMAT4 zinc finger, matrin-type 4 2.68085
PUS3 pseudouridylate synthase 3 2.66027
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.64694
NEFM neurofilament, medium polypeptide 2.6369
CENPE centromere protein E, 312kDa 2.62939
HAND1 heart and neural crest derivatives expressed 1 2.6146
C1QB complement component 1, q subcomponent, B chain 2.58864
CCNB2 cyclin B2 2.55831
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.52815
HBA1 hemoglobin, alpha 1 2.52412
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.50584
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.48239
STAC SH3 and cysteine rich domain 2.46733
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.45276
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.4506
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.4498
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 2.41488
GTPBP3 GTP binding protein 3 (mitochondrial) 2.41266
SCAMP5 secretory carrier membrane protein 5 2.40301
GOLGA6L9 golgin A6 family-like 9 2.39402
ZNF318 zinc finger protein 318 2.38975
POPDC3 popeye domain containing 3 2.36933
TRMT61B tRNA methyltransferase 61B 2.34447
EPHX3 epoxide hydrolase 3 2.34438
C1QA complement component 1, q subcomponent, A chain 2.34066
SYT1 synaptotagmin I 2.33618
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 2.32528
SCN3B sodium channel, voltage gated, type III beta subunit 2.30919
NPTX1 neuronal pentraxin I 2.30769
VCPKMT valosin containing protein lysine (K) methyltransferase 2.29944
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.28522
MFAP4 microfibrillar-associated protein 4 2.28453
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.27292
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 2.27005
CEP72 centrosomal protein 72kDa 2.25109
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.24529
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.23
SLIT2 slit homolog 2 (Drosophila) 2.22902
ISL1 ISL LIM homeobox 1 2.22382
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 2.2026
ICE2 interactor of little elongation complex ELL subunit 2 2.19139
RIMBP2 RIMS binding protein 2 2.19003
PTPRN protein tyrosine phosphatase, receptor type, N 2.18769
MRTFB myocardin related transcription factor B 2.18563
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.18072
TAGLN3 transgelin 3 2.17648
PARP6 poly (ADP-ribose) polymerase family, member 6 2.17541
SCG3 secretogranin III 2.17241
DNAAF5 dynein, axonemal, assembly factor 5 2.15755
PNPLA6 patatin-like phospholipase domain containing 6 2.14901
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.13823
WDR91 WD repeat domain 91 2.13067
PLPPR4 phospholipid phosphatase related 4 2.12879
PER1 period circadian clock 1 2.1278
CTSC cathepsin C 2.12512
TTLL7 tubulin tyrosine ligase-like family member 7 2.1209
APLNR apelin receptor 2.11232
PELO pelota homolog (Drosophila) 2.11151
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.10056
YOD1 YOD1 deubiquitinase 2.09721
ADAMTSL3 ADAMTS-like 3 2.08994
WDR73 WD repeat domain 73 2.06683
LMAN1 lectin, mannose-binding, 1 2.05614
POGLUT2 protein O-glucosyltransferase 2 2.04848
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.04652
ANAPC10 anaphase promoting complex subunit 10 2.04045
WDR3 WD repeat domain 3 2.03928
RYR1 ryanodine receptor 1 (skeletal) 2.03409
SRSF8 serine/arginine-rich splicing factor 8 2.03299
STIMATE STIM activating enhancer 2.03257
NEMF nuclear export mediator factor 2.03147
CDC7 cell division cycle 7 2.01579
SLC68A1 solute carrier family 68 member 1 2.01133
TPP2 tripeptidyl peptidase II 2.01107
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.00589

decreased expression

Symbol Name Standardized Value
PLK1 polo-like kinase 1 -5.30828
COG2 component of oligomeric golgi complex 2 -5.14138
MSMO1 methylsterol monooxygenase 1 -4.80918
DNM1L dynamin 1-like -4.74187
COG7 component of oligomeric golgi complex 7 -4.07563
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.77044
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.76167
BASP1 brain abundant, membrane attached signal protein 1 -3.60092
AKIRIN1 akirin 1 -3.2009
STXBP2 syntaxin binding protein 2 -3.13367
TRAPPC3 trafficking protein particle complex 3 -2.9736
EIF3I eukaryotic translation initiation factor 3, subunit I -2.81629
ECI2 enoyl-CoA delta isomerase 2 -2.81531
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.7814
CLOCK clock circadian regulator -2.77955
PEF1 penta-EF-hand domain containing 1 -2.7002
KAT7 K(lysine) acetyltransferase 7 -2.6738
MED21 mediator complex subunit 21 -2.64494
MSN moesin -2.59311
MCM3 minichromosome maintenance complex component 3 -2.54996
NPPA natriuretic peptide A -2.51608
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.43271
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -2.43169
BORCS6 BLOC-1 related complex subunit 6 -2.41225
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.40576
TRIM68 tripartite motif containing 68 -2.37854
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -2.3578
RESF1 retroelement silencing factor 1 -2.34753
VWA1 von Willebrand factor A domain containing 1 -2.32898
S100A3 S100 calcium binding protein A3 -2.32664
FLNB filamin B, beta -2.30917
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.30538
SERGEF secretion regulating guanine nucleotide exchange factor -2.30308
STK38L serine/threonine kinase 38 like -2.28092
SCYL3 SCY1-like 3 (S. cerevisiae) -2.27571
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -2.26924
DYSF dysferlin -2.26225
COG4 component of oligomeric golgi complex 4 -2.24357
TRMT5 tRNA methyltransferase 5 -2.23409
RBM42 RNA binding motif protein 42 -2.23067
TM7SF3 transmembrane 7 superfamily member 3 -2.22815
HMGN2 high mobility group nucleosomal binding domain 2 -2.21635
ACOX2 acyl-CoA oxidase 2, branched chain -2.21482
CHMP4B charged multivesicular body protein 4B -2.20336
MAST4 microtubule associated serine/threonine kinase family member 4 -2.19951
CANT1 calcium activated nucleotidase 1 -2.18382
HDAC1 histone deacetylase 1 -2.18225
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -2.16754
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.16588
ORAI3 ORAI calcium release-activated calcium modulator 3 -2.16484
SUN2 Sad1 and UNC84 domain containing 2 -2.16053
PLIN3 perilipin 3 -2.15862
PNRC1 proline-rich nuclear receptor coactivator 1 -2.15797
ARF3 ADP-ribosylation factor 3 -2.1556
RHOC ras homolog family member C -2.14872
MECR mitochondrial trans-2-enoyl-CoA reductase -2.14069
PHACTR4 phosphatase and actin regulator 4 -2.13949
KIFBP kinesin family binding protein -2.13929
IL2RG interleukin 2 receptor, gamma -2.09326
TBC1D13 TBC1 domain family, member 13 -2.07601
MKRN2 makorin ring finger protein 2 -2.06651
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.05709
PLA2G15 phospholipase A2, group XV -2.05267
RNF2 ring finger protein 2 -2.04839
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.04517
TRAFD1 TRAF-type zinc finger domain containing 1 -2.04464
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -2.04205
ERGIC2 ERGIC and golgi 2 -2.02617
ZNF274 zinc finger protein 274 -2.02358
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.0188
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -2.01414
STAP2 signal transducing adaptor family member 2 -2.01239
ZNF593 zinc finger protein 593 -2.00419
CHMP6 charged multivesicular body protein 6 -2.00236