CRCGN015_MCF10A.WT.HP_24H:P07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-aminodiphenyl 100.07 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EAPP E2F-associated phosphoprotein 4.98372
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.51384
CXCL2 chemokine (C-X-C motif) ligand 2 4.21655
GLRX glutaredoxin (thioltransferase) 3.21714
ANKRD10 ankyrin repeat domain 10 3.11961
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.98284
SRP54 signal recognition particle 54kDa 2.77395
SCFD1 sec1 family domain containing 1 2.73364
CHN1 chimerin 1 2.57111
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.55033
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.53531
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.43805
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2.32997
NUCB2 nucleobindin 2 2.31749
ACAA1 acetyl-CoA acyltransferase 1 2.24258
SPTSSA serine palmitoyltransferase, small subunit A 2.22865
TRIB3 tribbles pseudokinase 3 2.22444
CCNL1 cyclin L1 2.1849
INSIG1 insulin induced gene 1 2.18119
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 2.14814
NEMP1 nuclear envelope integral membrane protein 1 2.09641
BCAP31 B-cell receptor-associated protein 31 2.09419
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.09254
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.08014
CEMIP2 cell migration inducing hyaluronidase 2 2.06325
HYOU1 hypoxia up-regulated 1 2.02474
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.01476

decreased expression

Symbol Name Standardized Value
FBXO21 F-box protein 21 -5.09535
RALGDS ral guanine nucleotide dissociation stimulator -4.52206
COG7 component of oligomeric golgi complex 7 -4.10282
CCNB1 cyclin B1 -4.03864
GDF15 growth differentiation factor 15 -3.04357
NT5DC2 5'-nucleotidase domain containing 2 -3.02956
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.88171
STXBP2 syntaxin binding protein 2 -2.86861
SNX6 sorting nexin 6 -2.80373
ARID4B AT rich interactive domain 4B (RBP1-like) -2.79282
FBXO7 F-box protein 7 -2.67344
SORBS3 sorbin and SH3 domain containing 3 -2.54896
FAIM Fas apoptotic inhibitory molecule -2.51595
CCDC85B coiled-coil domain containing 85B -2.50078
TCTA T-cell leukemia translocation altered -2.46002
SMAD7 SMAD family member 7 -2.37735
KIFBP kinesin family binding protein -2.25402
CERT1 ceramide transporter 1 -2.18236
FAM131A family with sequence similarity 131, member A -2.17083
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.12575
MRPL23 mitochondrial ribosomal protein L23 -2.10368
BID BH3 interacting domain death agonist -2.09865
ZNF134 zinc finger protein 134 -2.06924
CANT1 calcium activated nucleotidase 1 -2.06497
MXRA7 matrix-remodelling associated 7 -2.05512
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.05456
ITPKC inositol-trisphosphate 3-kinase C -2.02152
GMIP GEM interacting protein -2.01942
COG4 component of oligomeric golgi complex 4 -2.0181
TPPP tubulin polymerization promoting protein -2.00676
DIABLO diablo, IAP-binding mitochondrial protein -2.00388