CRCGN015_MCF10A.WT.HP_24H:P08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-aminodiphenyl 33.36 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 5.19278
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.82874
C2CD2 C2 calcium-dependent domain containing 2 4.23824
HMOX1 heme oxygenase 1 4.17703
SSBP2 single-stranded DNA binding protein 2 4.01999
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.88662
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.3517
MAPK9 mitogen-activated protein kinase 9 2.27615
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.17909
NOTCH1 notch 1 2.16058
CRLF3 cytokine receptor-like factor 3 2.08741
FBXL12 F-box and leucine-rich repeat protein 12 2.06855
STX4 syntaxin 4 2.06455
PUM1 pumilio RNA-binding family member 1 2.06334
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.02906
SRP54 signal recognition particle 54kDa 2.02851
XPC xeroderma pigmentosum, complementation group C 2.02144

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -5.29993
MAPK13 mitogen-activated protein kinase 13 -4.62343
KIF14 kinesin family member 14 -4.0878
SLC25A46 solute carrier family 25, member 46 -3.64684
STXBP2 syntaxin binding protein 2 -3.53695
GADD45B growth arrest and DNA-damage-inducible, beta -2.96779
COG7 component of oligomeric golgi complex 7 -2.87063
GLI1 GLI family zinc finger 1 -2.58344
SNRPE small nuclear ribonucleoprotein polypeptide E -2.53581
LAD1 ladinin 1 -2.46341
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.44779
SH3BP1 SH3-domain binding protein 1 -2.44296
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.42452
CENPB centromere protein B, 80kDa -2.36276
TCTA T-cell leukemia translocation altered -2.34517
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.3304
CCDC69 coiled-coil domain containing 69 -2.24711
KLHDC4 kelch domain containing 4 -2.24648
CDC20 cell division cycle 20 -2.23099
CTSD cathepsin D -2.22839
IFI27 interferon, alpha-inducible protein 27 -2.22776
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.21792
CSRNP3 cysteine-serine-rich nuclear protein 3 -2.2154
ATP5F1E ATP synthase F1 subunit epsilon -2.19703
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -2.18821
PTPRS protein tyrosine phosphatase, receptor type, S -2.14265
MEA1 male-enhanced antigen 1 -2.13536
ARID4B AT rich interactive domain 4B (RBP1-like) -2.12856
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.12363
PFN1 profilin 1 -2.11556
ACTN4 actinin, alpha 4 -2.09186
FBXL8 F-box and leucine-rich repeat protein 8 -2.09081
COX7C cytochrome c oxidase subunit VIIc -2.0883
IGFBP7 insulin-like growth factor binding protein 7 -2.04282
MAPK4 mitogen-activated protein kinase 4 -2.04143
CHRNE cholinergic receptor, nicotinic, epsilon (muscle) -2.01871
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -2.0089
DOK2 docking protein 2, 56kDa -2.0079