CRCGN015_MCF10A.WT.HP_24H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description megestrol 99.64 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 4.64089
SYNGAP1 synaptic Ras GTPase activating protein 1 4.18955
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 3.33319
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.03315
FHL2 four and a half LIM domains 2 3.02931
COL4A1 collagen, type IV, alpha 1 2.75647
ACAA1 acetyl-CoA acyltransferase 1 2.74935
EPN2 epsin 2 2.70121
CALU calumenin 2.65007
NCK2 NCK adaptor protein 2 2.61159
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.46203
IER3 immediate early response 3 2.41579
PLIN1 perilipin 1 2.41044
FAT1 FAT atypical cadherin 1 2.39106
MMD monocyte to macrophage differentiation-associated 2.34952
CREB3L2 cAMP responsive element binding protein 3-like 2 2.34583
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.23245
REV1 REV1, polymerase (DNA directed) 2.1945
FNDC3B fibronectin type III domain containing 3B 2.17128
ADIPOQ adiponectin, C1Q and collagen domain containing 2.15904
RBP4 retinol binding protein 4, plasma 2.13992
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.13515
DUSP4 dual specificity phosphatase 4 2.11969
FABP4 fatty acid binding protein 4, adipocyte 2.10496
DUSP6 dual specificity phosphatase 6 2.05944
IL4R interleukin 4 receptor 2.04353
G0S2 G0/G1 switch 2 2.04323

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -5.42734
TRAPPC3 trafficking protein particle complex 3 -4.83878
GADD45B growth arrest and DNA-damage-inducible, beta -4.83487
RGS2 regulator of G-protein signaling 2 -4.40796
SLC35F2 solute carrier family 35, member F2 -3.84898
PSIP1 PC4 and SFRS1 interacting protein 1 -3.64345
MRPS15 mitochondrial ribosomal protein S15 -3.55602
RALGDS ral guanine nucleotide dissociation stimulator -3.33934
EXOSC4 exosome component 4 -3.10315
CORO1A coronin, actin binding protein, 1A -3.0499
BPHL biphenyl hydrolase-like (serine hydrolase) -3.04201
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.94727
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.94434
BID BH3 interacting domain death agonist -2.78885
ADRB2 adrenoceptor beta 2, surface -2.66298
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.58413
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.57129
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.52154
AGO1 argonaute RISC catalytic component 1 -2.50848
CTSD cathepsin D -2.48386
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.48359
LOC102724594 splicing factor U2AF 35 kDa subunit -2.45761
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.41485
STXBP2 syntaxin binding protein 2 -2.40233
ZMYM4 zinc finger, MYM-type 4 -2.39648
DNM2 dynamin 2 -2.33429
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing -2.30095
COPS7A COP9 signalosome subunit 7A -2.28773
IL2RG interleukin 2 receptor, gamma -2.28705
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.27816
COG7 component of oligomeric golgi complex 7 -2.26219
ZNF428 zinc finger protein 428 -2.25594
CD4 CD4 molecule -2.24735
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.2138
CHMP6 charged multivesicular body protein 6 -2.20412
METRN meteorin, glial cell differentiation regulator -2.20369
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.16847
EMD emerin -2.11725
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.11085
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa -2.07448
IPO13 importin 13 -2.06754
KIAA0513 KIAA0513 -2.05256
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.04289
CDCA8 cell division cycle associated 8 -2.04183
TCEAL4 transcription elongation factor A (SII)-like 4 -2.03514
NOSIP nitric oxide synthase interacting protein -2.02327
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.00864
ARRB2 arrestin, beta 2 -2.00789
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.00566
TNIP1 TNFAIP3 interacting protein 1 -2.00295