CRCGN015_MCF10A.WT.HP_24H:P11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description megestrol 33.21 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.43125
SYNGAP1 synaptic Ras GTPase activating protein 1 3.78033
FHL2 four and a half LIM domains 2 3.60453
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.08901
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.91321
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.90976
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.86585
COL4A1 collagen, type IV, alpha 1 2.85478
CALU calumenin 2.7513
INSIG1 insulin induced gene 1 2.71144
FKBP14 FK506 binding protein 14, 22 kDa 2.69217
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.52377
MAPK9 mitogen-activated protein kinase 9 2.50492
EXOSC10 exosome component 10 2.45872
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.41246
CENPE centromere protein E, 312kDa 2.36358
TPD52L2 tumor protein D52-like 2 2.34895
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.34431
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.28392
WDR11 WD repeat domain 11 2.28166
SMAD3 SMAD family member 3 2.22235
DUSP4 dual specificity phosphatase 4 2.17126
GLB1 galactosidase, beta 1 2.17033
C2CD2 C2 calcium-dependent domain containing 2 2.1632
CAPRIN2 caprin family member 2 2.14786
SLC35F2 solute carrier family 35, member F2 2.11412
LRP10 low density lipoprotein receptor-related protein 10 2.11118
IER3 immediate early response 3 2.10837
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) 2.02252

decreased expression

Symbol Name Standardized Value
RGS2 regulator of G-protein signaling 2 -5.09707
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.41249
NPDC1 neural proliferation, differentiation and control, 1 -3.99478
ADRB2 adrenoceptor beta 2, surface -3.88403
LDHD lactate dehydrogenase D -3.75952
ARFIP2 ADP-ribosylation factor interacting protein 2 -3.42238
S100A8 S100 calcium binding protein A8 -3.30339
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.17318
HRAS Harvey rat sarcoma viral oncogene homolog -2.9233
BPHL biphenyl hydrolase-like (serine hydrolase) -2.88956
CD320 CD320 molecule -2.78175
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.78099
KRT14 keratin 14, type I -2.72147
PRR15L proline rich 15-like -2.63195
METRN meteorin, glial cell differentiation regulator -2.51089
PKP3 plakophilin 3 -2.49314
ZDHHC11B zinc finger, DHHC-type containing 11B -2.47659
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) -2.45751
CCDC85B coiled-coil domain containing 85B -2.38742
COG7 component of oligomeric golgi complex 7 -2.38117
HEATR1 HEAT repeat containing 1 -2.37263
HLX H2.0-like homeobox -2.36326
CREG1 cellular repressor of E1A-stimulated genes 1 -2.35977
CAPN1 calpain 1, (mu/I) large subunit -2.345
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.34204
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.32914
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.31426
ZNF669 zinc finger protein 669 -2.28277
ARF5 ADP-ribosylation factor 5 -2.25028
ARL2 ADP-ribosylation factor-like 2 -2.24714
ZNF394 zinc finger protein 394 -2.24449
RALGDS ral guanine nucleotide dissociation stimulator -2.23719
RPP40 ribonuclease P/MRP 40kDa subunit -2.18229
MTERF3 mitochondrial transcription termination factor 3 -2.14083
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.12643
IRF7 interferon regulatory factor 7 -2.1223
MTCH2 mitochondrial carrier 2 -2.11661
PUS7 pseudouridylate synthase 7 (putative) -2.11386
ZNF14 zinc finger protein 14 -2.10266
H2AC25 H2A clustered histone 25 -2.07598
MUC1 mucin 1, cell surface associated -2.05998
KRT5 keratin 5, type II -2.05609
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.0556
HSPB1 heat shock 27kDa protein 1 -2.05495
ADAM15 ADAM metallopeptidase domain 15 -2.05325
MEPCE methylphosphate capping enzyme -2.04085
EIF5 eukaryotic translation initiation factor 5 -2.0369
GADD45B growth arrest and DNA-damage-inducible, beta -2.02978
KRABD4 KRAB domain containing 4 -2.01545
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.0103
REXO2 RNA exonuclease 2 -2.00954
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 -2.00745
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.00009