CRCGN015_MCF10A.WT.HP_24H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description uracil mustard 33.81 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

349 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 8.40254
RGS2 regulator of G-protein signaling 2 6.29985
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 5.53611
DDB2 damage-specific DNA binding protein 2, 48kDa 5.3264
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.28975
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.78095
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.62672
LRP10 low density lipoprotein receptor-related protein 10 4.48125
FHL2 four and a half LIM domains 2 4.26681
INPP1 inositol polyphosphate-1-phosphatase 4.10539
FAT1 FAT atypical cadherin 1 4.02294
BAX BCL2-associated X protein 3.82397
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.73577
CEMIP2 cell migration inducing hyaluronidase 2 3.55477
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.4956
SPAG4 sperm associated antigen 4 3.45649
ZNF586 zinc finger protein 586 3.39757
TRIM22 tripartite motif containing 22 3.35818
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.34689
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.33736
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.33536
DUSP14 dual specificity phosphatase 14 3.33014
GRN granulin 3.3266
MX1 MX dynamin-like GTPase 1 3.27686
AGR2 anterior gradient 2 3.27053
CNRIP1 cannabinoid receptor interacting protein 1 3.23717
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.21812
DENND2D DENN/MADD domain containing 2D 3.12506
ISG15 ISG15 ubiquitin-like modifier 3.11956
EPHA2 EPH receptor A2 3.09813
TICAM1 toll-like receptor adaptor molecule 1 3.0735
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.07132
IRF9 interferon regulatory factor 9 3.05056
IFI6 interferon, alpha-inducible protein 6 3.03506
ECH1 enoyl CoA hydratase 1, peroxisomal 3.02673
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.98497
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.96916
PMP22 peripheral myelin protein 22 2.96891
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.91243
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.89227
OPTN optineurin 2.88976
IRF7 interferon regulatory factor 7 2.85298
PLK3 polo-like kinase 3 2.81845
NUCB2 nucleobindin 2 2.78873
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.77391
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 2.76138
RTP4 receptor (chemosensory) transporter protein 4 2.73714
TSPAN1 tetraspanin 1 2.73445
MUC1 mucin 1, cell surface associated 2.73186
GPR87 G protein-coupled receptor 87 2.69331
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.69156
SAMD9 sterile alpha motif domain containing 9 2.68579
TNS4 tensin 4 2.68531
STAT1 signal transducer and activator of transcription 1, 91kDa 2.66547
CYB5R1 cytochrome b5 reductase 1 2.64326
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.63744
KRT34 keratin 34, type I 2.62596
SPRR1B small proline-rich protein 1B 2.62505
ZMAT3 zinc finger, matrin-type 3 2.61874
KLHL21 kelch-like family member 21 2.61519
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.59836
ADRB2 adrenoceptor beta 2, surface 2.5858
KRT6A keratin 6A, type II 2.57782
ITPKC inositol-trisphosphate 3-kinase C 2.56958
LIMK2 LIM domain kinase 2 2.56806
STXBP1 syntaxin binding protein 1 2.55197
RPS27L ribosomal protein S27-like 2.54995
TMEM59 transmembrane protein 59 2.54583
SESN1 sestrin 1 2.53842
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.52169
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.52124
IFI44L interferon-induced protein 44-like 2.50931
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.49662
TMEM40 transmembrane protein 40 2.47398
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.46927
KRT16 keratin 16, type I 2.44644
DSG3 desmoglein 3 2.40918
MST1R macrophage stimulating 1 receptor 2.40116
KRT6B keratin 6B, type II 2.39791
SLC10A3 solute carrier family 10, member 3 2.39546
ZNF14 zinc finger protein 14 2.3806
GJB5 gap junction protein, beta 5, 31.1kDa 2.36227
PIEZO2 piezo-type mechanosensitive ion channel component 2 2.34558
NOP10 NOP10 ribonucleoprotein 2.341
YPEL5 yippee-like 5 (Drosophila) 2.32701
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.32608
OASL 2'-5'-oligoadenylate synthetase-like 2.32423
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.32218
ANXA4 annexin A4 2.3179
APOL6 apolipoprotein L, 6 2.30841
CCDC90B coiled-coil domain containing 90B 2.30724
CTSV cathepsin V 2.30389
CREB5 cAMP responsive element binding protein 5 2.3038
STX12 syntaxin 12 2.3037
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.29453
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.2912
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.28002
ZNF224 zinc finger protein 224 2.27788
NRIP1 nuclear receptor interacting protein 1 2.2722
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.26628
TRIM45 tripartite motif containing 45 2.26551
TCTN1 tectonic family member 1 2.26266
PTHLH parathyroid hormone-like hormone 2.25531
TUFT1 tuftelin 1 2.25241
AEN apoptosis enhancing nuclease 2.24228
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.23252
CTF1 cardiotrophin 1 2.23053
LYPD3 LY6/PLAUR domain containing 3 2.22578
MUC13 mucin 13, cell surface associated 2.22204
TP53I3 tumor protein p53 inducible protein 3 2.21695
SPATA20 spermatogenesis associated 20 2.21569
RIGI RNA sensor RIG-I 2.21394
PLBD1 phospholipase B domain containing 1 2.20982
PTPRE protein tyrosine phosphatase, receptor type, E 2.20653
EML2 echinoderm microtubule associated protein like 2 2.20625
ZNF365 zinc finger protein 365 2.20093
POC1B-GALNT4 POC1B-GALNT4 readthrough 2.19881
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.19796
PYCARD PYD and CARD domain containing 2.19738
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.18433
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.18015
ZNF432 zinc finger protein 432 2.17896
KIAA0040 KIAA0040 2.17497
DGKA diacylglycerol kinase, alpha 80kDa 2.17483
FASN fatty acid synthase 2.17166
SPRR1A small proline-rich protein 1A 2.16826
MVP major vault protein 2.1658
ZNF350 zinc finger protein 350 2.1656
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.16334
INF2 inverted formin, FH2 and WH2 domain containing 2.16286
ZNF134 zinc finger protein 134 2.16147
FILIP1L filamin A interacting protein 1-like 2.1552
ZNF544 zinc finger protein 544 2.14996
ZBED2 zinc finger, BED-type containing 2 2.14977
CALCOCO1 calcium binding and coiled-coil domain 1 2.14765
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.14632
YIPF1 Yip1 domain family, member 1 2.1448
IFI44 interferon-induced protein 44 2.14344
GLRX glutaredoxin (thioltransferase) 2.14319
BCAS1 breast carcinoma amplified sequence 1 2.14152
ZNF548 zinc finger protein 548 2.13882
XAF1 XIAP associated factor 1 2.13183
SIRT2 sirtuin 2 2.12466
ZNF85 zinc finger protein 85 2.1156
TRIAP1 TP53 regulated inhibitor of apoptosis 1 2.10714
ITGB4 integrin, beta 4 2.10417
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.09889
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.09763
F3 coagulation factor III (thromboplastin, tissue factor) 2.09687
TGFA transforming growth factor, alpha 2.09215
LIF leukemia inhibitory factor 2.09175
EFS embryonal Fyn-associated substrate 2.08798
DDR1 discoidin domain receptor tyrosine kinase 1 2.08482
NRBF2 nuclear receptor binding factor 2 2.08304
BNC1 basonuclin 1 2.07851
COPZ2 coatomer protein complex, subunit zeta 2 2.07737
CRYAB crystallin, alpha B 2.07573
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.07184
TSG101 tumor susceptibility 101 2.07036
TOPBP1 topoisomerase (DNA) II binding protein 1 2.06068
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.05985
SUGCT succinyl-CoA:glutarate-CoA transferase 2.05794
SEC14L2 SEC14-like 2 (S. cerevisiae) 2.05752
LOC102724428 serine/threonine-protein kinase SIK1 2.05706
MINDY1 MINDY lysine 48 deubiquitinase 1 2.05667
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.05145
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.05118
KLK5 kallikrein-related peptidase 5 2.05004
TGM1 transglutaminase 1 2.04959
LDHD lactate dehydrogenase D 2.04511
MOBP myelin-associated oligodendrocyte basic protein 2.04376
NIT1 nitrilase 1 2.03993
MOG myelin oligodendrocyte glycoprotein 2.03894
CCP110 centriolar coiled coil protein 110kDa 2.03792
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.03785
DNASE1L1 deoxyribonuclease I-like 1 2.03677
LAX1 lymphocyte transmembrane adaptor 1 2.03304
TRIM21 tripartite motif containing 21 2.03088
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.02929
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.02717
PKP1 plakophilin 1 2.02355
PCDHGA5 protocadherin gamma subfamily A, 5 2.0208
TUBB6 tubulin, beta 6 class V 2.02067
IFI35 interferon-induced protein 35 2.02065
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.01319
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.01116
SKIC2 SKI2 subunit of superkiller complex 2.00756
PYGL phosphorylase, glycogen, liver 2.00293

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.59497
UBE2C ubiquitin-conjugating enzyme E2C -9.28272
CDC20 cell division cycle 20 -9.07473
KIF20A kinesin family member 20A -8.67347
PSRC1 proline/serine-rich coiled-coil 1 -7.99053
LBR lamin B receptor -7.75739
PLK1 polo-like kinase 1 -7.63004
THAP11 THAP domain containing 11 -6.8801
TOP2A topoisomerase (DNA) II alpha 170kDa -6.29043
AURKA aurora kinase A -5.20266
CENPA centromere protein A -5.04007
CD320 CD320 molecule -4.89834
KIF4A kinesin family member 4A -4.79706
KIF14 kinesin family member 14 -4.76177
BIRC5 baculoviral IAP repeat containing 5 -4.72836
HMMR hyaluronan-mediated motility receptor (RHAMM) -4.36669
DEPDC1 DEP domain containing 1 -4.29107
CDCA8 cell division cycle associated 8 -4.28489
CCNA2 cyclin A2 -4.1855
COG2 component of oligomeric golgi complex 2 -4.17343
MRPS2 mitochondrial ribosomal protein S2 -4.1135
DDIT4 DNA-damage-inducible transcript 4 -4.05334
PIMREG PICALM interacting mitotic regulator -4.0513
CDCA3 cell division cycle associated 3 -3.97364
NEK2 NIMA-related kinase 2 -3.91074
PARP1 poly (ADP-ribose) polymerase 1 -3.87267
TMEM109 transmembrane protein 109 -3.87235
MRPL12 mitochondrial ribosomal protein L12 -3.82069
HJURP Holliday junction recognition protein -3.78789
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.72593
CCNB1 cyclin B1 -3.63979
STXBP2 syntaxin binding protein 2 -3.5989
PTTG1 pituitary tumor-transforming 1 -3.5429
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.46713
TPX2 TPX2, microtubule-associated -3.42956
CETN3 centrin, EF-hand protein, 3 -3.3852
MSN moesin -3.34844
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.32476
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.25587
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.21413
CCNF cyclin F -3.19378
KIF23 kinesin family member 23 -3.18556
CDC25C cell division cycle 25C -3.16442
CDC25B cell division cycle 25B -3.14659
SPAG5 sperm associated antigen 5 -3.01031
KIF15 kinesin family member 15 -2.9788
HMGB2 high mobility group box 2 -2.96142
SPC25 SPC25, NDC80 kinetochore complex component -2.95448
DBF4 DBF4 zinc finger -2.95013
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.94108
TTK TTK protein kinase -2.93393
CDKN3 cyclin-dependent kinase inhibitor 3 -2.92468
CEP55 centrosomal protein 55kDa -2.918
OIP5 Opa interacting protein 5 -2.9156
NCAPD2 non-SMC condensin I complex, subunit D2 -2.8909
PYCR1 pyrroline-5-carboxylate reductase 1 -2.87551
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.86668
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.85799
CDK4 cyclin-dependent kinase 4 -2.85146
TKT transketolase -2.83762
CD44 CD44 molecule (Indian blood group) -2.81584
RPIA ribose 5-phosphate isomerase A -2.75311
KIF18A kinesin family member 18A -2.7455
SPDL1 spindle apparatus coiled-coil protein 1 -2.74074
FOXM1 forkhead box M1 -2.73156
NCAPH non-SMC condensin I complex, subunit H -2.72772
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.69366
TACC3 transforming, acidic coiled-coil containing protein 3 -2.67592
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.6572
UBE2S ubiquitin-conjugating enzyme E2S -2.65482
ERCC6L excision repair cross-complementation group 6-like -2.65396
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.64324
ADISSP adipose secreted signaling protein -2.64093
NDC80 NDC80 kinetochore complex component -2.64042
MKI67 marker of proliferation Ki-67 -2.62451
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.61313
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.60983
ARHGAP11A Rho GTPase activating protein 11A -2.58709
FBXO5 F-box protein 5 -2.54697
ANKRD10 ankyrin repeat domain 10 -2.52411
BICRAL BICRA like chromatin remodeling complex associated protein -2.51902
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.51768
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.51739
CKAP5 cytoskeleton associated protein 5 -2.51467
CENPF centromere protein F, 350/400kDa -2.50959
TROAP trophinin associated protein -2.50288
TCOF1 Treacher Collins-Franceschetti syndrome 1 -2.4994
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.49752
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.49335
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.49092
HMGN4 high mobility group nucleosomal binding domain 4 -2.47985
SNRPA small nuclear ribonucleoprotein polypeptide A -2.45949
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.4522
SEC61G Sec61 gamma subunit -2.44159
NUSAP1 nucleolar and spindle associated protein 1 -2.43643
CBR3 carbonyl reductase 3 -2.41223
NLRP4 NLR family, pyrin domain containing 4 -2.4078
KIF11 kinesin family member 11 -2.40564
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.39972
RACGAP1 Rac GTPase activating protein 1 -2.37568
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.3709
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -2.35249
NTHL1 nth endonuclease III-like 1 (E. coli) -2.34797
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.34267
MRPS18B mitochondrial ribosomal protein S18B -2.33835
CNOT8 CCR4-NOT transcription complex, subunit 8 -2.32647
PBK PDZ binding kinase -2.32382
ARID4B AT rich interactive domain 4B (RBP1-like) -2.31424
NUP93 nucleoporin 93kDa -2.30881
MTERF3 mitochondrial transcription termination factor 3 -2.30824
HDAC2 histone deacetylase 2 -2.30682
BORA bora, aurora kinase A activator -2.30449
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.29823
HSPA1A heat shock 70kDa protein 1A -2.28875
KDM1A lysine (K)-specific demethylase 1A -2.28015
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.27508
SKA1 spindle and kinetochore associated complex subunit 1 -2.25147
SUMF2 sulfatase modifying factor 2 -2.23855
TSPAN7 tetraspanin 7 -2.22117
KIF22 kinesin family member 22 -2.22076
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.21602
CDC23 cell division cycle 23 -2.20644
MAGEA2B melanoma antigen family A2B -2.20547
MDC1 mediator of DNA-damage checkpoint 1 -2.19458
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.19327
HEATR3 HEAT repeat containing 3 -2.19204
DTD1 D-tyrosyl-tRNA deacylase 1 -2.19155
MRPL37 mitochondrial ribosomal protein L37 -2.18963
CD81 CD81 molecule -2.18921
PRC1 protein regulator of cytokinesis 1 -2.18809
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.18758
RBM14-RBM4 RBM14-RBM4 readthrough -2.18569
TRIM28 tripartite motif containing 28 -2.18333
CDCA4 cell division cycle associated 4 -2.16569
CADPS2 Ca++-dependent secretion activator 2 -2.1511
MYLIP myosin regulatory light chain interacting protein -2.14303
NOP16 NOP16 nucleolar protein -2.13707
AURKB aurora kinase B -2.13649
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.13364
WRAP53 WD repeat containing, antisense to TP53 -2.12462
ARHGAP10 Rho GTPase activating protein 10 -2.12228
BOP1 block of proliferation 1 -2.11921
SAP30L SAP30-like -2.11079
DEK DEK proto-oncogene -2.09483
DPH2 DPH2 homolog (S. cerevisiae) -2.0933
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.07476
USP22 ubiquitin specific peptidase 22 -2.07344
CARM1 coactivator-associated arginine methyltransferase 1 -2.07311
NIPSNAP2 nipsnap homolog 2 -2.06655
GTPBP6 GTP binding protein 6 (putative) -2.06058
DNAAF2 dynein, axonemal, assembly factor 2 -2.06033
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.05671
PRPF8 pre-mRNA processing factor 8 -2.05294
TMPO thymopoietin -2.04555
TSKU tsukushi, small leucine rich proteoglycan -2.0436
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.03828
DCAF7 DDB1 and CUL4 associated factor 7 -2.02111
TATDN2 TatD DNase domain containing 2 -2.01884
DNM1 dynamin 1 -2.01403
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -2.00615
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -2.00564