CRCGN015_MCF10A.WT.HP_24H:P15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description uracil mustard 11.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

329 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MSRA methionine sulfoxide reductase A 6.92678
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.15336
RGS2 regulator of G-protein signaling 2 4.81814
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.69455
CDPF1 cysteine-rich, DPF motif domain containing 1 4.4585
DUSP14 dual specificity phosphatase 14 4.37808
SPRR1B small proline-rich protein 1B 4.06402
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.95243
KRT6A keratin 6A, type II 3.93483
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.80087
INPP1 inositol polyphosphate-1-phosphatase 3.79483
EPN2 epsin 2 3.72338
SPRR1A small proline-rich protein 1A 3.71628
PYGL phosphorylase, glycogen, liver 3.62216
LRP10 low density lipoprotein receptor-related protein 10 3.62167
PPIC peptidylprolyl isomerase C (cyclophilin C) 3.43885
MAMLD1 mastermind-like domain containing 1 3.43154
SPAG4 sperm associated antigen 4 3.4143
KRT16 keratin 16, type I 3.29571
STXBP1 syntaxin binding protein 1 3.28421
ABHD6 abhydrolase domain containing 6 3.27143
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.26551
SPRR2B small proline-rich protein 2B 3.20963
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 3.20518
TGM1 transglutaminase 1 3.17189
CA14 carbonic anhydrase XIV 3.0858
KRT34 keratin 34, type I 3.00848
CIDEB cell death-inducing DFFA-like effector b 2.96802
ASCC3 activating signal cointegrator 1 complex subunit 3 2.95168
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.93696
NAGK N-acetylglucosamine kinase 2.92602
CXCR4 chemokine (C-X-C motif) receptor 4 2.893
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 2.88743
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.88432
GRN granulin 2.87767
CAPN1 calpain 1, (mu/I) large subunit 2.85825
TMPRSS11D transmembrane protease, serine 11D 2.82999
STAT2 signal transducer and activator of transcription 2, 113kDa 2.82474
S100A14 S100 calcium binding protein A14 2.79063
LYPD3 LY6/PLAUR domain containing 3 2.78385
KRT6B keratin 6B, type II 2.7698
SYPL1 synaptophysin-like 1 2.76361
CALCOCO1 calcium binding and coiled-coil domain 1 2.75057
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.72587
USP6 ubiquitin specific peptidase 6 2.71021
CLCA2 chloride channel accessory 2 2.70021
MICALL1 MICAL-like 1 2.69637
IVL involucrin 2.69113
LGALS7B lectin, galactoside-binding, soluble, 7B 2.66744
TICAM1 toll-like receptor adaptor molecule 1 2.66704
ZNF365 zinc finger protein 365 2.66701
ITGB7 integrin, beta 7 2.66646
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.65301
SPATA20 spermatogenesis associated 20 2.63903
IL1RN interleukin 1 receptor antagonist 2.61815
CDK2 cyclin-dependent kinase 2 2.57476
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.57105
DSG3 desmoglein 3 2.53325
ALS2CL ALS2 C-terminal like 2.52464
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.52076
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 2.50849
ULBP2 UL16 binding protein 2 2.50641
LY6D lymphocyte antigen 6 complex, locus D 2.49436
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.48499
EPHX3 epoxide hydrolase 3 2.48206
SYTL2 synaptotagmin-like 2 2.44182
ADRB2 adrenoceptor beta 2, surface 2.44017
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.43957
NEO1 neogenin 1 2.43902
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.43344
GATA3 GATA binding protein 3 2.43341
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.40904
SUGCT succinyl-CoA:glutarate-CoA transferase 2.4083
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.40482
TBX19 T-box 19 2.39506
STX4 syntaxin 4 2.38445
SPRR3 small proline-rich protein 3 2.37585
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.37173
CLDND1 claudin domain containing 1 2.36712
CRCT1 cysteine-rich C-terminal 1 2.35907
FAT2 FAT atypical cadherin 2 2.35542
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.34911
KRT13 keratin 13, type I 2.34863
DENND4B DENN/MADD domain containing 4B 2.3449
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.34203
OXA1L oxidase (cytochrome c) assembly 1-like 2.33801
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 2.33776
MUC1 mucin 1, cell surface associated 2.32934
COMMD3 COMM domain containing 3 2.32919
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.32284
CUL1 cullin 1 2.32141
TRIM22 tripartite motif containing 22 2.3214
TRAPPC14 trafficking protein particle complex subunit 14 2.31913
GSTK1 glutathione S-transferase kappa 1 2.31556
AGR2 anterior gradient 2 2.29376
RHCG Rh family, C glycoprotein 2.29139
GPR87 G protein-coupled receptor 87 2.28289
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.2722
OXCT1 3-oxoacid CoA transferase 1 2.27054
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.27
ERBB3 erb-b2 receptor tyrosine kinase 3 2.26408
WDR11 WD repeat domain 11 2.2635
SYNGAP1 synaptic Ras GTPase activating protein 1 2.2616
MAPK6 mitogen-activated protein kinase 6 2.25873
IL36G interleukin 36, gamma 2.25807
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.25708
MAN2B1 mannosidase, alpha, class 2B, member 1 2.25657
GSAP gamma-secretase activating protein 2.23915
TSPAN6 tetraspanin 6 2.23474
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.23332
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.22875
ZNF260 zinc finger protein 260 2.22256
ZNF862 zinc finger protein 862 2.22089
GSTA4 glutathione S-transferase alpha 4 2.21369
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 2.21243
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 2.21048
KRT17 keratin 17, type I 2.20385
NNT nicotinamide nucleotide transhydrogenase 2.19281
ETHE1 ethylmalonic encephalopathy 1 2.19238
ZDHHC6 zinc finger, DHHC-type containing 6 2.18551
IFI6 interferon, alpha-inducible protein 6 2.18349
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.18337
METTL3 methyltransferase like 3 2.18171
ZBTB32 zinc finger and BTB domain containing 32 2.18092
NISCH nischarin 2.18077
TFEC transcription factor EC 2.17207
STARD5 StAR-related lipid transfer (START) domain containing 5 2.17176
RABL6 RAB, member RAS oncogene family-like 6 2.17158
PEA15 phosphoprotein enriched in astrocytes 15 2.16733
MINDY3 MINDY lysine 48 deubiquitinase 3 2.16468
DGKA diacylglycerol kinase, alpha 80kDa 2.15716
AURKC aurora kinase C 2.1535
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.15271
TBX21 T-box 21 2.1478
ZNF750 zinc finger protein 750 2.14665
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.14287
UBE3C ubiquitin protein ligase E3C 2.14091
FDXR ferredoxin reductase 2.13987
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.13797
ATP8B4 ATPase, class I, type 8B, member 4 2.1305
CEMIP2 cell migration inducing hyaluronidase 2 2.12944
CSTA cystatin A (stefin A) 2.12568
CREG1 cellular repressor of E1A-stimulated genes 1 2.12104
BHLHE40 basic helix-loop-helix family, member e40 2.12101
ZMAT3 zinc finger, matrin-type 3 2.12085
MPPE1 metallophosphoesterase 1 2.12082
CYTH1 cytohesin 1 2.11757
EPHA2 EPH receptor A2 2.11038
CROT carnitine O-octanoyltransferase 2.10348
MICA MHC class I polypeptide-related sequence A 2.10335
GM2A GM2 ganglioside activator 2.10317
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 2.10264
KLF4 Kruppel-like factor 4 (gut) 2.09943
RPL29 ribosomal protein L29 2.09916
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 2.09709
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.09606
EMP1 epithelial membrane protein 1 2.09128
REEP2 receptor accessory protein 2 2.08685
TYR tyrosinase 2.08678
KRT9 keratin 9, type I 2.08361
OCLN occludin 2.08324
PLBD1 phospholipase B domain containing 1 2.08003
ZNF212 zinc finger protein 212 2.0798
MTCL1 microtubule crosslinking factor 1 2.07709
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.06491
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.06434
CAPN3 calpain 3, (p94) 2.06021
EML2 echinoderm microtubule associated protein like 2 2.0596
SESN1 sestrin 1 2.05368
CRNN cornulin 2.04635
MTA2 metastasis associated 1 family, member 2 2.03753
MYO18A myosin XVIIIA 2.032
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 2.03101
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.03023
CSAD cysteine sulfinic acid decarboxylase 2.02895
RRAGB Ras-related GTP binding B 2.02717
MYCBP MYC binding protein 2.02441
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.02215
CEPT1 choline/ethanolamine phosphotransferase 1 2.02076
FAM131B family with sequence similarity 131, member B 2.01802
TRIM25 tripartite motif containing 25 2.01797
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.01752
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.01613
BIRC7 baculoviral IAP repeat containing 7 2.01511
PSG3 pregnancy specific beta-1-glycoprotein 3 2.00979
DGKG diacylglycerol kinase, gamma 90kDa 2.00571

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -7.59526
THAP11 THAP domain containing 11 -6.24471
CCNB2 cyclin B2 -6.12739
PLK1 polo-like kinase 1 -6.0075
CDK4 cyclin-dependent kinase 4 -5.61094
DDIT4 DNA-damage-inducible transcript 4 -5.5297
PSRC1 proline/serine-rich coiled-coil 1 -5.52053
CDC20 cell division cycle 20 -5.45143
RUVBL1 RuvB-like AAA ATPase 1 -4.9766
LBR lamin B receptor -4.72663
RPN1 ribophorin I -4.30886
STXBP2 syntaxin binding protein 2 -4.11756
AURKA aurora kinase A -4.03396
PUF60 poly-U binding splicing factor 60KDa -3.8333
TATDN2 TatD DNase domain containing 2 -3.73337
TKT transketolase -3.51363
ATF5 activating transcription factor 5 -3.39894
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.30101
NUP93 nucleoporin 93kDa -3.29629
KIF20A kinesin family member 20A -3.28689
CENPA centromere protein A -3.26959
SQSTM1 sequestosome 1 -3.19727
CD320 CD320 molecule -3.1866
DYNLT3 dynein, light chain, Tctex-type 3 -3.16381
RCC1 regulator of chromosome condensation 1 -3.16215
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -3.13839
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -3.07302
NCAPD2 non-SMC condensin I complex, subunit D2 -3.01218
HSPD1 heat shock 60kDa protein 1 (chaperonin) -3.01037
ENOPH1 enolase-phosphatase 1 -2.9242
EXOSC4 exosome component 4 -2.88743
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.87783
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.84066
GLB1L2 galactosidase, beta 1-like 2 -2.8275
USP22 ubiquitin specific peptidase 22 -2.79471
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.76879
EPCAM epithelial cell adhesion molecule -2.74406
KIF14 kinesin family member 14 -2.74124
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.71553
CHMP6 charged multivesicular body protein 6 -2.71317
TRIM28 tripartite motif containing 28 -2.70616
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -2.70365
ZW10 zw10 kinetochore protein -2.69649
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.68158
RALY RALY heterogeneous nuclear ribonucleoprotein -2.67155
KIF4A kinesin family member 4A -2.66075
PARP1 poly (ADP-ribose) polymerase 1 -2.64408
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.63571
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -2.62654
KARS1 lysyl-tRNA synthetase 1 -2.61173
DEPDC1 DEP domain containing 1 -2.60909
TTK TTK protein kinase -2.5899
CDC25B cell division cycle 25B -2.56407
NGRN neugrin, neurite outgrowth associated -2.55757
CDCA4 cell division cycle associated 4 -2.55434
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.5454
RPIA ribose 5-phosphate isomerase A -2.53157
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.51124
HJURP Holliday junction recognition protein -2.50888
TP53BP2 tumor protein p53 binding protein 2 -2.49546
BIRC5 baculoviral IAP repeat containing 5 -2.49349
PAK1IP1 PAK1 interacting protein 1 -2.48987
IRAK1 interleukin-1 receptor-associated kinase 1 -2.48017
KDM3A lysine (K)-specific demethylase 3A -2.46731
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.46659
KIFBP kinesin family binding protein -2.46572
EIF3B eukaryotic translation initiation factor 3, subunit B -2.44004
AHCY adenosylhomocysteinase -2.43375
CBR3 carbonyl reductase 3 -2.42882
CDCA3 cell division cycle associated 3 -2.41992
TUFM Tu translation elongation factor, mitochondrial -2.3982
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.38491
MALT1 MALT1 paracaspase -2.37833
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -2.37106
CARM1 coactivator-associated arginine methyltransferase 1 -2.3689
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.35854
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.35849
BID BH3 interacting domain death agonist -2.34311
RNASE7 ribonuclease, RNase A family, 7 -2.30191
TBC1D16 TBC1 domain family, member 16 -2.29904
TWNK twinkle mtDNA helicase -2.29766
SF3A2 splicing factor 3a, subunit 2, 66kDa -2.26252
NTHL1 nth endonuclease III-like 1 (E. coli) -2.26213
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.25274
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.24146
KIFC1 kinesin family member C1 -2.2355
CDCA8 cell division cycle associated 8 -2.23099
MAD2L1BP MAD2L1 binding protein -2.2261
HMGB2 high mobility group box 2 -2.21874
SUMF2 sulfatase modifying factor 2 -2.21785
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.21331
TOMM34 translocase of outer mitochondrial membrane 34 -2.19753
TPX2 TPX2, microtubule-associated -2.19509
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.18941
NANS N-acetylneuraminic acid synthase -2.18939
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.18789
CTPS2 CTP synthase 2 -2.18735
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.18522
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.18108
TM9SF3 transmembrane 9 superfamily member 3 -2.17841
ZNF580 zinc finger protein 580 -2.17504
RAB20 RAB20, member RAS oncogene family -2.17401
NDC80 NDC80 kinetochore complex component -2.16679
CIRBP cold inducible RNA binding protein -2.15908
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -2.15691
MTERF3 mitochondrial transcription termination factor 3 -2.15167
NUDC nudC nuclear distribution protein -2.14748
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -2.13926
EXOSC5 exosome component 5 -2.13697
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.13239
PDCL3 phosducin-like 3 -2.13129
LOC112694756 uncharaterized LOC112694756 -2.11354
SPC25 SPC25, NDC80 kinetochore complex component -2.10889
ISLR immunoglobulin superfamily containing leucine-rich repeat -2.07997
CDKN3 cyclin-dependent kinase inhibitor 3 -2.07884
ACOD1 aconitate decarboxylase 1 -2.07747
PIMREG PICALM interacting mitotic regulator -2.07731
NPM3 nucleophosmin/nucleoplasmin 3 -2.07295
AATF apoptosis antagonizing transcription factor -2.07253
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.07209
GGT5 gamma-glutamyltransferase 5 -2.06722
CYCS cytochrome c, somatic -2.05909
NAXD NAD(P)HX dehydratase -2.05639
MAP1S microtubule-associated protein 1S -2.04571
ECT2 epithelial cell transforming 2 -2.04559
ISOC1 isochorismatase domain containing 1 -2.04544
RBM42 RNA binding motif protein 42 -2.03624
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.03574
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.03502
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.03111
MRPL37 mitochondrial ribosomal protein L37 -2.02984
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.02113
UBQLN2 ubiquilin 2 -2.01776
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.01621
BASP1 brain abundant, membrane attached signal protein 1 -2.01584
OSBPL11 oxysterol binding protein-like 11 -2.01264
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -2.00995
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.00979
MTFR1 mitochondrial fission regulator 1 -2.00857
TACC3 transforming, acidic coiled-coil containing protein 3 -2.0071
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.00649
BYSL bystin-like -2.00643
ACOT2 acyl-CoA thioesterase 2 -2.00584