CRCGN015_MCF10A.WT.HP_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description amsonic acid 100.55 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

150 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.61825
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 4.98017
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.96809
SPAG4 sperm associated antigen 4 4.78188
CCDC92 coiled-coil domain containing 92 4.39768
E2F2 E2F transcription factor 2 4.36689
MAMLD1 mastermind-like domain containing 1 4.13449
ECD ecdysoneless homolog (Drosophila) 3.91761
EVL Enah/Vasp-like 3.91599
INSL4 insulin-like 4 (placenta) 3.32433
RPL39L ribosomal protein L39-like 3.27566
ACAA1 acetyl-CoA acyltransferase 1 3.26606
FBXO17 F-box protein 17 3.0769
ICOS inducible T-cell co-stimulator 3.06056
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 3.05362
LEP leptin 2.84976
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.84616
CRYAB crystallin, alpha B 2.82721
AGR2 anterior gradient 2 2.79028
TIMP4 TIMP metallopeptidase inhibitor 4 2.77215
TDG thymine-DNA glycosylase 2.68878
NPIPB6 nuclear pore complex interacting protein family, member B6 2.64838
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.60141
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.59518
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 2.5945
WDR11 WD repeat domain 11 2.59095
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 2.5907
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.58021
ANKRD10 ankyrin repeat domain 10 2.56601
TCTN1 tectonic family member 1 2.55851
TMEM101 transmembrane protein 101 2.53932
GRIA3 glutamate receptor, ionotropic, AMPA 3 2.5327
SIRPG signal-regulatory protein gamma 2.52398
CIDEC cell death-inducing DFFA-like effector c 2.51185
DHDDS dehydrodolichyl diphosphate synthase 2.51176
MSH5 mutS homolog 5 2.51021
SUOX sulfite oxidase 2.42799
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.4279
HAVCR1 hepatitis A virus cellular receptor 1 2.40802
SSX5 synovial sarcoma, X breakpoint 5 2.39868
LGSN lengsin, lens protein with glutamine synthetase domain 2.39357
PXDNL peroxidasin-like 2.37935
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.37603
TK2 thymidine kinase 2, mitochondrial 2.36367
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.36142
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.35916
RASA4B RAS p21 protein activator 4B 2.34471
RASSF9 Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 2.34045
COMP cartilage oligomeric matrix protein 2.33738
MTA2 metastasis associated 1 family, member 2 2.31565
IL12RB2 interleukin 12 receptor, beta 2 2.31259
RAG1 recombination activating gene 1 2.29926
HACD2 3-hydroxyacyl-CoA dehydratase 2 2.28162
SEC61B Sec61 beta subunit 2.2442
RFPL2 ret finger protein-like 2 2.23869
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.22454
PDE11A phosphodiesterase 11A 2.21891
CLCNKA chloride channel, voltage-sensitive Ka 2.2091
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.20533
FBXL2 F-box and leucine-rich repeat protein 2 2.191
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.18998
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.18608
NOVA1 neuro-oncological ventral antigen 1 2.18518
GALNS galactosamine (N-acetyl)-6-sulfatase 2.17918
CDH10 cadherin 10, type 2 (T2-cadherin) 2.17538
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 2.16841
IFNG interferon, gamma 2.16463
BBS1 Bardet-Biedl syndrome 1 2.16457
POMT1 protein-O-mannosyltransferase 1 2.1569
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.15486
IL21 interleukin 21 2.14564
BARX2 BARX homeobox 2 2.1448
MDFIC MyoD family inhibitor domain containing 2.13926
LYRM9 LYR motif containing 9 2.13915
GSTT4 glutathione S-transferase theta 4 2.13869
AURKC aurora kinase C 2.13348
TCTN3 tectonic family member 3 2.12463
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.12261
GABARAPL1 GABA(A) receptor-associated protein like 1 2.11998
LAG3 lymphocyte-activation gene 3 2.11749
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.11309
POU4F2 POU class 4 homeobox 2 2.11198
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 2.09777
PTBP2 polypyrimidine tract binding protein 2 2.09684
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.09134
TMEM255A transmembrane protein 255A 2.08576
LMO1 LIM domain only 1 (rhombotin 1) 2.08533
DLK2 delta-like 2 homolog (Drosophila) 2.08338
KRT3 keratin 3, type II 2.05751
CENPC centromere protein C 2.05739
CDH18 cadherin 18, type 2 2.05387
SLC16A4 solute carrier family 16, member 4 2.04891
IFNB1 interferon, beta 1, fibroblast 2.048
IL22 interleukin 22 2.04745
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.0455
PAGE4 P antigen family, member 4 (prostate associated) 2.04043
OLFML3 olfactomedin-like 3 2.03868
MTM1 myotubularin 1 2.03274
KRT76 keratin 76, type II 2.02747
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.00356

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -6.57832
PARP2 poly (ADP-ribose) polymerase 2 -5.39747
TIMP1 TIMP metallopeptidase inhibitor 1 -4.95874
S100A8 S100 calcium binding protein A8 -4.78188
HSPA8 heat shock 70kDa protein 8 -4.68949
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.14069
OXA1L oxidase (cytochrome c) assembly 1-like -4.1038
METTL17 methyltransferase like 17 -3.92463
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -3.85233
PRMT5 protein arginine methyltransferase 5 -2.90865
GMPR2 guanosine monophosphate reductase 2 -2.89566
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.82775
ATF5 activating transcription factor 5 -2.78526
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.69471
FSCN1 fascin actin-bundling protein 1 -2.62311
ENC1 ectodermal-neural cortex 1 (with BTB domain) -2.60598
OCRL oculocerebrorenal syndrome of Lowe -2.58748
CCDC85B coiled-coil domain containing 85B -2.56094
STXBP2 syntaxin binding protein 2 -2.5189
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.51155
DLK1 delta-like 1 homolog (Drosophila) -2.47995
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.43574
CD320 CD320 molecule -2.4039
SCYL3 SCY1-like 3 (S. cerevisiae) -2.39264
NRGN neurogranin (protein kinase C substrate, RC3) -2.32993
PLPP2 phospholipid phosphatase 2 -2.32578
EMILIN1 elastin microfibril interfacer 1 -2.30847
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.30844
IQGAP1 IQ motif containing GTPase activating protein 1 -2.29681
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -2.27179
LGALS9C lectin, galactoside-binding, soluble, 9C -2.27156
TMEM184B transmembrane protein 184B -2.23784
GASK1B golgi associated kinase 1B -2.22954
DAD1 defender against cell death 1 -2.22661
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.2098
ADORA2B adenosine A2b receptor -2.19643
BGN biglycan -2.18005
ENO2 enolase 2 (gamma, neuronal) -2.16
IGBP1 immunoglobulin (CD79A) binding protein 1 -2.14578
MMP11 matrix metallopeptidase 11 -2.12836
SARS1 seryl-tRNA synthetase 1 -2.11486
STOML2 stomatin (EPB72)-like 2 -2.09575
SH2B3 SH2B adaptor protein 3 -2.0957
PLPP6 phospholipid phosphatase 6 -2.09109
CENPB centromere protein B, 80kDa -2.06722
MYDGF myeloid-derived growth factor -2.04975
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.04869
CLTA clathrin, light chain A -2.04128
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -2.02714
MRC1 mannose receptor, C type 1 -2.02588