CRCGN015_MCF10A.WT.HP_24H:P18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description amsonic acid 11.17 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 3.42335
SPAG4 sperm associated antigen 4 3.32578
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.94145
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.77624
KDM5D lysine (K)-specific demethylase 5D 2.75476
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.63873
KIF5C kinesin family member 5C 2.53598
WFS1 Wolfram syndrome 1 (wolframin) 2.50517
H2BC21 H2B clustered histone 21 2.30192
TMPRSS11D transmembrane protease, serine 11D 2.28987
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.18455
USP9Y ubiquitin specific peptidase 9, Y-linked 2.07671
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.01619

decreased expression

Symbol Name Standardized Value
DSG2 desmoglein 2 -6.17039
PCNA proliferating cell nuclear antigen -3.71149
STXBP2 syntaxin binding protein 2 -3.59563
TES testin LIM domain protein -3.54898
CAB39 calcium binding protein 39 -3.50251
CCDC86 coiled-coil domain containing 86 -2.96175
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.54099
STAP2 signal transducing adaptor family member 2 -2.50913
UFM1 ubiquitin-fold modifier 1 -2.49188
SMC1A structural maintenance of chromosomes 1A -2.46795
PFN1 profilin 1 -2.44997
NUP93 nucleoporin 93kDa -2.3993
CBR3 carbonyl reductase 3 -2.39315
DDIT4 DNA-damage-inducible transcript 4 -2.31126
TIMP1 TIMP metallopeptidase inhibitor 1 -2.18309
SORBS3 sorbin and SH3 domain containing 3 -2.06687
KLHL21 kelch-like family member 21 -2.06429
DDRGK1 DDRGK domain containing 1 -2.05005
EXOSC4 exosome component 4 -2.04594
PANK2 pantothenate kinase 2 -2.03391