CRCGN015_MCF10A.WT.HP_24H:P20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description spironolactone 33.72 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

599 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
H2BC12 H2B clustered histone 12 6.21789
TMEM50A transmembrane protein 50A 5.97644
FHL2 four and a half LIM domains 2 5.78983
CXCR4 chemokine (C-X-C motif) receptor 4 5.21107
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.95714
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.57342
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 4.526
MSRA methionine sulfoxide reductase A 4.47942
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 4.41625
ADGRE5 adhesion G protein-coupled receptor E5 4.20906
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.17078
GPER1 G protein-coupled estrogen receptor 1 4.00908
LYN LYN proto-oncogene, Src family tyrosine kinase 3.82708
CEMIP2 cell migration inducing hyaluronidase 2 3.82267
AOC1 amine oxidase, copper containing 1 3.8216
SIRT3 sirtuin 3 3.66798
CNRIP1 cannabinoid receptor interacting protein 1 3.6291
PCCA propionyl CoA carboxylase, alpha polypeptide 3.51218
HBA1 hemoglobin, alpha 1 3.47402
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.46054
IGF1R insulin-like growth factor 1 receptor 3.44089
SH2D2A SH2 domain containing 2A 3.36194
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 3.30922
TMEM242 transmembrane protein 242 3.29204
GPR87 G protein-coupled receptor 87 3.24573
DPP6 dipeptidyl-peptidase 6 3.24535
SMNDC1 survival motor neuron domain containing 1 3.23535
CTLA4 cytotoxic T-lymphocyte-associated protein 4 3.2312
ACAA1 acetyl-CoA acyltransferase 1 3.2046
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 3.18509
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.16773
ZNF75D zinc finger protein 75D 3.16011
LGMN legumain 3.13842
H2AC6 H2A clustered histone 6 3.11473
SH3GL3 SH3-domain GRB2-like 3 3.09886
LRP10 low density lipoprotein receptor-related protein 10 3.0559
H2BC9 H2B clustered histone 9 3.03287
OR5I1 olfactory receptor, family 5, subfamily I, member 1 3.01225
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 3.00058
GNLY granulysin 2.95848
OMG oligodendrocyte myelin glycoprotein 2.94996
SMAD3 SMAD family member 3 2.93705
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.91468
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 2.88359
CEP83 centrosomal protein 83kDa 2.87914
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.87631
ZNF195 zinc finger protein 195 2.86325
FGF9 fibroblast growth factor 9 2.84823
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.84457
ZHX2 zinc fingers and homeoboxes 2 2.8438
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.84232
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.80547
FNTA farnesyltransferase, CAAX box, alpha 2.79058
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.76897
GALNS galactosamine (N-acetyl)-6-sulfatase 2.7554
ATG2B autophagy related 2B 2.74278
ZMPSTE24 zinc metallopeptidase STE24 2.74132
TMEM9B TMEM9 domain family, member B 2.73191
S100G S100 calcium binding protein G 2.73018
S100A4 S100 calcium binding protein A4 2.72426
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.70708
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.69563
TRAPPC10 trafficking protein particle complex 10 2.68089
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.67893
H1-2 H1.2 linker histone, cluster member 2.64774
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 2.64756
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.64572
CD8B CD8b molecule 2.64412
FAM131B family with sequence similarity 131, member B 2.64308
COL4A1 collagen, type IV, alpha 1 2.6383
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.63459
CCL4 chemokine (C-C motif) ligand 4 2.62717
CCL5 chemokine (C-C motif) ligand 5 2.61897
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.61895
RASL11B RAS-like, family 11, member B 2.6019
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.60188
KERA keratocan 2.59934
TPMT thiopurine S-methyltransferase 2.59658
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.58803
LSR lipolysis stimulated lipoprotein receptor 2.58778
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.57834
BMP1 bone morphogenetic protein 1 2.5781
B3GAT1 beta-1,3-glucuronyltransferase 1 2.57516
YAF2 YY1 associated factor 2 2.5735
OPRPN opiorphin prepropeptide 2.56846
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.56304
GCC2 GRIP and coiled-coil domain containing 2 2.55241
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.54434
RGCC regulator of cell cycle 2.54406
GTPBP8 GTP-binding protein 8 (putative) 2.54251
ZDHHC6 zinc finger, DHHC-type containing 6 2.53572
CLCN6 chloride channel, voltage-sensitive 6 2.52473
IKZF2 IKAROS family zinc finger 2 (Helios) 2.52331
TM9SF3 transmembrane 9 superfamily member 3 2.51828
H2BC5 H2B clustered histone 5 2.51332
FASLG Fas ligand (TNF superfamily, member 6) 2.51261
CLEC4E C-type lectin domain family 4, member E 2.49187
MAST2 microtubule associated serine/threonine kinase 2 2.47611
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.47368
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.47173
PLAG1 pleiomorphic adenoma gene 1 2.47095
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 2.47051
ASCC3 activating signal cointegrator 1 complex subunit 3 2.46668
GAN gigaxonin 2.4597
STYK1 serine/threonine/tyrosine kinase 1 2.45817
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.45533
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2.45301
FGF20 fibroblast growth factor 20 2.44098
ECD ecdysoneless homolog (Drosophila) 2.4386
EIF3J eukaryotic translation initiation factor 3, subunit J 2.43608
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.42787
AGO2 argonaute RISC catalytic component 2 2.42559
PLCD1 phospholipase C, delta 1 2.4225
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.41908
EIF4A2 eukaryotic translation initiation factor 4A2 2.40954
DLX6 distal-less homeobox 6 2.40511
HOXA5 homeobox A5 2.39557
NALF1 NALCN channel auxiliary factor 1 2.3951
AIG1 androgen-induced 1 2.39469
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.39346
EFS embryonal Fyn-associated substrate 2.37937
PYHIN1 pyrin and HIN domain family, member 1 2.37532
CYSLTR2 cysteinyl leukotriene receptor 2 2.37091
CYTH1 cytohesin 1 2.36983
DPY19L4 dpy-19-like 4 (C. elegans) 2.3682
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.36024
CAMKMT calmodulin-lysine N-methyltransferase 2.36012
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.35545
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.35347
YIPF1 Yip1 domain family, member 1 2.34824
TMEM59 transmembrane protein 59 2.3458
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.34422
MYLK3 myosin light chain kinase 3 2.33894
IQSEC3 IQ motif and Sec7 domain 3 2.33791
EFHD1 EF-hand domain family, member D1 2.33514
TSG101 tumor susceptibility 101 2.33358
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.33312
PRKCD protein kinase C, delta 2.33049
SPATA2L spermatogenesis associated 2-like 2.32936
TUBG2 tubulin, gamma 2 2.32906
UGT8 UDP glycosyltransferase 8 2.32728
SPAG4 sperm associated antigen 4 2.32638
KLHL36 kelch-like family member 36 2.31723
PHF14 PHD finger protein 14 2.31721
SNTG1 syntrophin, gamma 1 2.31663
WDR44 WD repeat domain 44 2.31337
ERMAP erythroblast membrane-associated protein (Scianna blood group) 2.31257
RNF111 ring finger protein 111 2.31058
H2BC4 H2B clustered histone 4 2.30602
CNTNAP1 contactin associated protein 1 2.30317
FBXO40 F-box protein 40 2.303
TBX21 T-box 21 2.30046
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.29904
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.29656
PLAUR plasminogen activator, urokinase receptor 2.29036
AOPEP aminopeptidase O (putative) 2.28994
SYNDIG1 synapse differentiation inducing 1 2.28891
TUBB2B tubulin, beta 2B class IIb 2.28856
ASCL3 achaete-scute family bHLH transcription factor 3 2.28804
ZXDB zinc finger, X-linked, duplicated B 2.28441
NOTCH1 notch 1 2.28385
UBXN2B UBX domain protein 2B 2.28321
LAG3 lymphocyte-activation gene 3 2.28092
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 2.2792
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2.27671
GBP2 guanylate binding protein 2, interferon-inducible 2.27593
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.27282
PSG11 pregnancy specific beta-1-glycoprotein 11 2.27199
KCTD11 potassium channel tetramerization domain containing 11 2.27129
GBX2 gastrulation brain homeobox 2 2.27031
IDS iduronate 2-sulfatase 2.26984
SLC35B1 solute carrier family 35, member B1 2.26867
KLHL2 kelch-like family member 2 2.26856
KIF5A kinesin family member 5A 2.26717
VNN1 vanin 1 2.26663
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.26336
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.2627
SYF2 SYF2 pre-mRNA-splicing factor 2.262
TSGA10 testis specific, 10 2.26153
OPTN optineurin 2.26141
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 2.26111
NPY4R2 neuropeptide Y receptor Y4-2 2.25872
LNPEP leucyl/cystinyl aminopeptidase 2.25067
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.24848
GAGE1 G antigen 1 2.2459
ANKRD10 ankyrin repeat domain 10 2.23861
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.23773
KRT36 keratin 36, type I 2.23576
RNF39 ring finger protein 39 2.23429
CYLD cylindromatosis (turban tumor syndrome) 2.22588
DRP2 dystrophin related protein 2 2.22326
THOC1 THO complex 1 2.22255
EN2 engrailed homeobox 2 2.22239
PRELID3A PRELI domain containing 3A 2.21941
LAMB3 laminin, beta 3 2.21673
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.21548
EDAR ectodysplasin A receptor 2.21509
PDGFA platelet-derived growth factor alpha polypeptide 2.21383
NPY2R neuropeptide Y receptor Y2 2.21246
CRABP2 cellular retinoic acid binding protein 2 2.20993
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.20943
TGM4 transglutaminase 4 2.2067
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.20561
TEX14 testis expressed 14 2.20268
DEPTOR DEP domain containing MTOR-interacting protein 2.20053
CST7 cystatin F (leukocystatin) 2.19942
ZNF223 zinc finger protein 223 2.19744
KMT5A lysine methyltransferase 5A 2.19656
SOX2 SRY (sex determining region Y)-box 2 2.19624
IRAK4 interleukin-1 receptor-associated kinase 4 2.19497
FBXW10B F-box and WD repeat domain containing 10B 2.19436
SLITRK2 SLIT and NTRK-like family, member 2 2.19267
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.19201
SIRT2 sirtuin 2 2.19149
IL22 interleukin 22 2.18987
ITGB7 integrin, beta 7 2.18973
PLCL2 phospholipase C-like 2 2.18955
RIOK3 RIO kinase 3 2.18757
QSER1 glutamine and serine rich 1 2.18634
ECH1 enoyl CoA hydratase 1, peroxisomal 2.18627
TMEM120B transmembrane protein 120B 2.1851
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.18131
TSC1 tuberous sclerosis 1 2.18112
SMIM29 small integral membrane protein 29 2.17893
PSG2 pregnancy specific beta-1-glycoprotein 2 2.17592
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.17476
A1CF APOBEC1 complementation factor 2.17466
CDKL3 cyclin-dependent kinase-like 3 2.17237
TTC21B tetratricopeptide repeat domain 21B 2.16876
KRT16 keratin 16, type I 2.16624
MTDH metadherin 2.16411
FBXO46 F-box protein 46 2.15708
LGI1 leucine-rich, glioma inactivated 1 2.15365
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.15329
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.15182
ANO3 anoctamin 3 2.149
WDR33 WD repeat domain 33 2.1482
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.14802
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 2.14749
CAB39L calcium binding protein 39-like 2.14386
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.14169
ATP8B4 ATPase, class I, type 8B, member 4 2.14148
RAG1 recombination activating gene 1 2.13997
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.13835
TNNT2 troponin T type 2 (cardiac) 2.13621
SESN1 sestrin 1 2.13266
GSE1 Gse1 coiled-coil protein 2.13018
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.12894
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.12875
SARAF store-operated calcium entry-associated regulatory factor 2.12671
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 2.12301
COL17A1 collagen, type XVII, alpha 1 2.12213
IRGQ immunity-related GTPase family, Q 2.12173
THY1 Thy-1 cell surface antigen 2.11629
TRAF3 TNF receptor-associated factor 3 2.11626
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 2.11609
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 2.11522
SIM1 single-minded family bHLH transcription factor 1 2.10807
COL18A1 collagen, type XVIII, alpha 1 2.10759
NPPB natriuretic peptide B 2.10494
TXK TXK tyrosine kinase 2.10486
COMP cartilage oligomeric matrix protein 2.10472
PAMR1 peptidase domain containing associated with muscle regeneration 1 2.10393
SLC10A3 solute carrier family 10, member 3 2.10372
EPS8L2 EPS8-like 2 2.10339
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.10297
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.10258
RASA4 RAS p21 protein activator 4 2.10112
TMEM127 transmembrane protein 127 2.1005
ZNF286A zinc finger protein 286A 2.0998
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.09601
CTSE cathepsin E 2.096
GRIA3 glutamate receptor, ionotropic, AMPA 3 2.09474
COL2A1 collagen, type II, alpha 1 2.09135
TRAM1 translocation associated membrane protein 1 2.08951
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.08843
TWSG1 twisted gastrulation BMP signaling modulator 1 2.0862
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.08539
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.08537
MTMR10 myotubularin related protein 10 2.08426
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 2.08374
IL15 interleukin 15 2.0828
VAV3 vav 3 guanine nucleotide exchange factor 2.08271
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.08172
DRD1 dopamine receptor D1 2.08046
PDE11A phosphodiesterase 11A 2.08034
IFNGR1 interferon gamma receptor 1 2.07884
CIRSR corepressor of RBPJ and splicing regulator 2.07794
VPS13B vacuolar protein sorting 13 homolog B (yeast) 2.07631
CEMIP cell migration inducing protein, hyaluronan binding 2.07342
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.07265
LSM1 LSM1, U6 small nuclear RNA associated 2.07177
KRT20 keratin 20, type I 2.07132
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.07
CRTAM cytotoxic and regulatory T cell molecule 2.06887
GAS2 growth arrest-specific 2 2.06631
DCAF13 DDB1 and CUL4 associated factor 13 2.06603
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.0636
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.06341
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 2.06334
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.05871
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.05606
FAT1 FAT atypical cadherin 1 2.05561
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.0556
EPS8L3 EPS8-like 3 2.05093
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.046
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.04498
TDG thymine-DNA glycosylase 2.04408
ANKRD46 ankyrin repeat domain 46 2.0436
MMP12 matrix metallopeptidase 12 2.04347
TBX3 T-box 3 2.042
GML glycosylphosphatidylinositol anchored molecule like 2.0409
DMPK dystrophia myotonica-protein kinase 2.03885
MBOAT2 membrane bound O-acyltransferase domain containing 2 2.03481
PUF60 poly-U binding splicing factor 60KDa 2.0347
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 2.03454
ZNF532 zinc finger protein 532 2.03398
FXYD7 FXYD domain containing ion transport regulator 7 2.03322
ADTRP androgen-dependent TFPI-regulating protein 2.03298
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.03263
GHR growth hormone receptor 2.03101
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.02763
TRPS1 trichorhinophalangeal syndrome I 2.02643
MYO16 myosin XVI 2.02604
STUM stum, mechanosensory transduction mediator homolog 2.0257
TSPO2 translocator protein 2 2.02563
H2AC19 H2A clustered histone 19 2.02498
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.02409
NEMF nuclear export mediator factor 2.02385
TRIM49D2 tripartite motif containing 49D2 2.02344
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.02339
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.02296
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.02221
H2BC21 H2B clustered histone 21 2.02216
DUSP14 dual specificity phosphatase 14 2.02084
TAS2R16 taste receptor, type 2, member 16 2.01881
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 2.0179
QPCTL glutaminyl-peptide cyclotransferase-like 2.01597
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 2.0152
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.01504
SPINK4 serine peptidase inhibitor, Kazal type 4 2.01501
KCNK2 potassium channel, two pore domain subfamily K, member 2 2.0144
BCAS1 breast carcinoma amplified sequence 1 2.01326
EDN2 endothelin 2 2.01298
CD37 CD37 molecule 2.01265
RAPSN receptor-associated protein of the synapse 2.01234
REV1 REV1, polymerase (DNA directed) 2.0104
TAS2R13 taste receptor, type 2, member 13 2.00882
ZNF821 zinc finger protein 821 2.00877
MED13 mediator complex subunit 13 2.00792
LGI2 leucine-rich repeat LGI family, member 2 2.00442
WRNIP1 Werner helicase interacting protein 1 2.0032
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.00138

decreased expression

Symbol Name Standardized Value
CDC45 cell division cycle 45 -8.22919
DDIT4 DNA-damage-inducible transcript 4 -7.95679
LBR lamin B receptor -6.08803
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.86907
CRTAP cartilage associated protein -5.6551
COG7 component of oligomeric golgi complex 7 -5.29388
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.28807
SCYL3 SCY1-like 3 (S. cerevisiae) -5.14878
KIF14 kinesin family member 14 -4.78351
INTS3 integrator complex subunit 3 -4.72986
KIFBP kinesin family binding protein -4.53069
UBE2C ubiquitin-conjugating enzyme E2C -4.47827
HIRIP3 HIRA interacting protein 3 -4.43084
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.4294
PSRC1 proline/serine-rich coiled-coil 1 -4.34006
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.17751
CDC20 cell division cycle 20 -4.16205
NLRP4 NLR family, pyrin domain containing 4 -4.13173
CHMP4B charged multivesicular body protein 4B -4.02099
PYCR1 pyrroline-5-carboxylate reductase 1 -4.01441
SNX6 sorting nexin 6 -3.87196
DSN1 DSN1, MIS12 kinetochore complex component -3.80336
DHPS deoxyhypusine synthase -3.75856
TKT transketolase -3.67606
VANGL1 VANGL planar cell polarity protein 1 -3.64953
MRPL12 mitochondrial ribosomal protein L12 -3.62422
TTC31 tetratricopeptide repeat domain 31 -3.57391
NGRN neugrin, neurite outgrowth associated -3.55919
CENPM centromere protein M -3.53162
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.46145
PAGR1 PAXIP1 associated glutamate-rich protein 1 -3.44408
HMG20B high mobility group 20B -3.36269
NCAPG2 non-SMC condensin II complex, subunit G2 -3.34144
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.33163
TAC4 tachykinin 4 (hemokinin) -3.33003
KIF20A kinesin family member 20A -3.30063
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.28446
CKS1B CDC28 protein kinase regulatory subunit 1B -3.25363
TUBG1 tubulin, gamma 1 -3.21256
HJURP Holliday junction recognition protein -3.20604
MEA1 male-enhanced antigen 1 -3.19863
MCM3 minichromosome maintenance complex component 3 -3.15745
ERCC6L excision repair cross-complementation group 6-like -3.14466
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.11241
MSMO1 methylsterol monooxygenase 1 -3.09571
CDCA8 cell division cycle associated 8 -3.06572
CDK4 cyclin-dependent kinase 4 -3.06445
PGM1 phosphoglucomutase 1 -3.01847
CDT1 chromatin licensing and DNA replication factor 1 -2.99685
TTK TTK protein kinase -2.99632
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.97709
AARS1 alanyl-tRNA synthetase 1 -2.97168
CYREN cell cycle regulator of NHEJ -2.96502
FOXM1 forkhead box M1 -2.95997
CDKN3 cyclin-dependent kinase inhibitor 3 -2.94882
PALB2 partner and localizer of BRCA2 -2.94023
PLK1 polo-like kinase 1 -2.93901
RPL39L ribosomal protein L39-like -2.91845
MRPS2 mitochondrial ribosomal protein S2 -2.91449
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.90435
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.90073
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.89334
MYG1 MYG1 exonuclease -2.87073
ACOT8 acyl-CoA thioesterase 8 -2.86943
ASF1B anti-silencing function 1B histone chaperone -2.86665
LYRM1 LYR motif containing 1 -2.82683
DCLRE1B DNA cross-link repair 1B -2.82636
NCAPH non-SMC condensin I complex, subunit H -2.82176
CDK1 cyclin-dependent kinase 1 -2.81559
MRPS16 mitochondrial ribosomal protein S16 -2.81077
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.80666
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.78913
ADNP2 ADNP homeobox 2 -2.78668
RNF167 ring finger protein 167 -2.78192
MIS18A MIS18 kinetochore protein A -2.76347
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.7506
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.73859
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.73617
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.72648
FAAP100 FA core complex associated protein 100 -2.70914
RNASEH2A ribonuclease H2, subunit A -2.7054
STX10 syntaxin 10 -2.69248
CCNA2 cyclin A2 -2.69013
CETN3 centrin, EF-hand protein, 3 -2.67813
CDCA3 cell division cycle associated 3 -2.6764
TACC3 transforming, acidic coiled-coil containing protein 3 -2.6722
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) -2.67173
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.65946
CANT1 calcium activated nucleotidase 1 -2.65561
AURKA aurora kinase A -2.64953
NHP2 NHP2 ribonucleoprotein -2.64841
MCM5 minichromosome maintenance complex component 5 -2.64264
NHLRC2 NHL repeat containing 2 -2.63767
INSIG1 insulin induced gene 1 -2.62688
RUSF1 RUS family member 1 -2.62526
CENPS-CORT CENPS-CORT readthrough -2.62504
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.61165
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.60665
GDF15 growth differentiation factor 15 -2.60603
AMZ2 archaelysin family metallopeptidase 2 -2.58875
MEPCE methylphosphate capping enzyme -2.56996
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.566
RBM12B RNA binding motif protein 12B -2.56293
PSMC3IP PSMC3 interacting protein -2.55372
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.55267
TUBA1C tubulin, alpha 1c -2.5447
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.53215
FANCI Fanconi anemia, complementation group I -2.52987
HAX1 HCLS1 associated protein X-1 -2.52517
PRC1 protein regulator of cytokinesis 1 -2.51659
SGSM3 small G protein signaling modulator 3 -2.51299
BRCA1 breast cancer 1, early onset -2.50183
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.49091
FIBP fibroblast growth factor (acidic) intracellular binding protein -2.4891
FASTKD5 FAST kinase domains 5 -2.46915
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.46585
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.46261
TIMP1 TIMP metallopeptidase inhibitor 1 -2.46111
KEAP1 kelch-like ECH-associated protein 1 -2.45318
CERT1 ceramide transporter 1 -2.45249
SAC3D1 SAC3 domain containing 1 -2.45169
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.44029
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.41334
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.41084
OXA1L oxidase (cytochrome c) assembly 1-like -2.39132
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.38884
KCTD12 potassium channel tetramerization domain containing 12 -2.38686
FARSA phenylalanyl-tRNA synthetase, alpha subunit -2.37566
APEH acylaminoacyl-peptide hydrolase -2.37091
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.36901
RFXANK regulatory factor X-associated ankyrin-containing protein -2.36532
TUBA1B tubulin, alpha 1b -2.36136
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.36006
TROAP trophinin associated protein -2.35995
THAP7 THAP domain containing 7 -2.35161
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.3513
TBC1D10B TBC1 domain family, member 10B -2.3448
SGF29 SAGA complex associated factor 29 -2.33875
CD320 CD320 molecule -2.33216
OXLD1 oxidoreductase-like domain containing 1 -2.32999
PCCB propionyl CoA carboxylase, beta polypeptide -2.3298
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.32925
STXBP2 syntaxin binding protein 2 -2.32793
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.32407
CCNF cyclin F -2.31955
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.31633
PXMP4 peroxisomal membrane protein 4, 24kDa -2.31375
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.31145
EXO1 exonuclease 1 -2.29412
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.29314
MKI67 marker of proliferation Ki-67 -2.28659
GET3 guided entry of tail-anchored proteins factor 3, ATPase -2.2622
RBM14-RBM4 RBM14-RBM4 readthrough -2.25749
REXO5 RNA exonuclease 5 -2.25722
UBFD1 ubiquitin family domain containing 1 -2.25644
BLMH bleomycin hydrolase -2.25404
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.24833
RACGAP1 Rac GTPase activating protein 1 -2.23803
CENPA centromere protein A -2.23564
ZNF551 zinc finger protein 551 -2.22623
TMEM147 transmembrane protein 147 -2.2241
POGK pogo transposable element with KRAB domain -2.22342
SNX17 sorting nexin 17 -2.22324
COG2 component of oligomeric golgi complex 2 -2.21621
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.21601
DONSON downstream neighbor of SON -2.21321
KIF4A kinesin family member 4A -2.21148
MCM10 minichromosome maintenance complex component 10 -2.21083
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.20902
PIR pirin (iron-binding nuclear protein) -2.20879
KIF15 kinesin family member 15 -2.20772
HMGN2 high mobility group nucleosomal binding domain 2 -2.20475
CENPI centromere protein I -2.20342
PAIP1 poly(A) binding protein interacting protein 1 -2.19892
RFC2 replication factor C (activator 1) 2, 40kDa -2.19446
ZNF672 zinc finger protein 672 -2.18921
TOMM34 translocase of outer mitochondrial membrane 34 -2.18598
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -2.18089
LAS1L LAS1-like (S. cerevisiae) -2.174
TPX2 TPX2, microtubule-associated -2.17038
TXNL4A thioredoxin-like 4A -2.16842
KNOP1 lysine-rich nucleolar protein 1 -2.16442
CCNB1 cyclin B1 -2.16075
TSPAN4 tetraspanin 4 -2.15631
SPAG5 sperm associated antigen 5 -2.15561
NIBAN1 niban apoptosis regulator 1 -2.15406
FEN1 flap structure-specific endonuclease 1 -2.14675
NAGA N-acetylgalactosaminidase, alpha- -2.14324
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.14292
TRAPPC8 trafficking protein particle complex 8 -2.14181
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.13736
ANKMY2 ankyrin repeat and MYND domain containing 2 -2.12817
TRMT5 tRNA methyltransferase 5 -2.12648
KIF23 kinesin family member 23 -2.12538
ZNF200 zinc finger protein 200 -2.1224
RGS2 regulator of G-protein signaling 2 -2.12155
SPC25 SPC25, NDC80 kinetochore complex component -2.12005
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.11162
SKA1 spindle and kinetochore associated complex subunit 1 -2.10467
HAUS4 HAUS augmin-like complex, subunit 4 -2.10409
NTHL1 nth endonuclease III-like 1 (E. coli) -2.10351
TUFM Tu translation elongation factor, mitochondrial -2.10329
SSRP1 structure specific recognition protein 1 -2.10321
ALCAM activated leukocyte cell adhesion molecule -2.10198
PPP1R3D protein phosphatase 1, regulatory subunit 3D -2.10161
BCL7B B-cell CLL/lymphoma 7B -2.10135
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.09994
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.08758
RNF130 ring finger protein 130 -2.08578
BIRC5 baculoviral IAP repeat containing 5 -2.08325
MTG1 mitochondrial ribosome-associated GTPase 1 -2.07583
NUDC nudC nuclear distribution protein -2.07418
SYBU syntabulin (syntaxin-interacting) -2.07138
GPR65 G protein-coupled receptor 65 -2.06983
PTTG1 pituitary tumor-transforming 1 -2.0682
RMI1 RecQ mediated genome instability 1 -2.06684
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.06507
CD34 CD34 molecule -2.06298
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.05915
BCL7C B-cell CLL/lymphoma 7C -2.05733
EMC9 ER membrane protein complex subunit 9 -2.05728
FANCG Fanconi anemia, complementation group G -2.05492
DHCR7 7-dehydrocholesterol reductase -2.05469
TUBA1A tubulin, alpha 1a -2.05443
TMED3 transmembrane emp24 protein transport domain containing 3 -2.05255
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.05
DENND4B DENN/MADD domain containing 4B -2.04576
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.04445
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.04337
CGGBP1 CGG triplet repeat binding protein 1 -2.04116
FAM20B family with sequence similarity 20, member B -2.04091
PRPF6 pre-mRNA processing factor 6 -2.03995
EXOSC8 exosome component 8 -2.0389
NELFB negative elongation factor complex member B -2.03534
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -2.03269
PARN poly(A)-specific ribonuclease -2.03118
AURKB aurora kinase B -2.03022
LYSET lysosomal enzyme trafficking factor -2.02881
UBE2S ubiquitin-conjugating enzyme E2S -2.01645
ACOD1 aconitate decarboxylase 1 -2.01606
POLK polymerase (DNA directed) kappa -2.01398
SHCBP1 SHC SH2-domain binding protein 1 -2.01191
RALY RALY heterogeneous nuclear ribonucleoprotein -2.00965
SNRPC small nuclear ribonucleoprotein polypeptide C -2.00815
ADISSP adipose secreted signaling protein -2.00423
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.00252