| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | dibenzo[a,h]pyrene 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
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268 genes differentially expressed following the CRCGN015_MCF10A.WT.HP_24H:P23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 7.11666 |
| LAGE3 | L antigen family, member 3 | 6.64847 |
| IDE | insulin-degrading enzyme | 4.4857 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 3.87852 |
| KDM5D | lysine (K)-specific demethylase 5D | 3.73099 |
| ANO10 | anoctamin 10 | 3.68021 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 3.61919 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 3.38777 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.37297 |
| ACTR8 | ARP8 actin-related protein 8 homolog (yeast) | 3.22736 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 3.1988 |
| MELK | maternal embryonic leucine zipper kinase | 3.1986 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 3.07192 |
| KLHL21 | kelch-like family member 21 | 3.03339 |
| MAMLD1 | mastermind-like domain containing 1 | 3.02237 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 2.96868 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.96345 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 2.95583 |
| UBQLN2 | ubiquilin 2 | 2.95175 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.92183 |
| ABHD6 | abhydrolase domain containing 6 | 2.84908 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.83877 |
| RSRP1 | arginine/serine-rich protein 1 | 2.80124 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | 2.77739 |
| MEF2C | myocyte enhancer factor 2C | 2.75904 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.71988 |
| TXNRD1 | thioredoxin reductase 1 | 2.71403 |
| FCHO1 | FCH domain only 1 | 2.70902 |
| F8A2 | coagulation factor VIII-associated 2 | 2.66383 |
| BRCC3 | BRCA1/BRCA2-containing complex, subunit 3 | 2.6636 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 2.65333 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.62478 |
| MFN1 | mitofusin 1 | 2.58179 |
| IFT81 | intraflagellar transport 81 | 2.54828 |
| GOLGA8A | golgin A8 family, member A | 2.52374 |
| ZFC3H1 | zinc finger, C3H1-type containing | 2.50549 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 2.48232 |
| ZNF706 | zinc finger protein 706 | 2.48069 |
| CCNL1 | cyclin L1 | 2.48032 |
| LEMD3 | LEM domain containing 3 | 2.47679 |
| CHMP1B | charged multivesicular body protein 1B | 2.45836 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | 2.45545 |
| ZMAT3 | zinc finger, matrin-type 3 | 2.40566 |
| SEC23IP | SEC23 interacting protein | 2.38294 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 2.38095 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 2.36949 |
| B4GALT6 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | 2.36713 |
| YIPF5 | Yip1 domain family, member 5 | 2.36383 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 2.35828 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 2.35121 |
| TMEM135 | transmembrane protein 135 | 2.34898 |
| HOXA5 | homeobox A5 | 2.34067 |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | 2.33476 |
| NLRP4 | NLR family, pyrin domain containing 4 | 2.33195 |
| TBC1D19 | TBC1 domain family, member 19 | 2.32882 |
| SLC10A3 | solute carrier family 10, member 3 | 2.29914 |
| RAB11FIP2 | RAB11 family interacting protein 2 (class I) | 2.2961 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 2.28911 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.28653 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 2.2818 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 2.2764 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 2.27448 |
| FAM50A | family with sequence similarity 50, member A | 2.27384 |
| TDG | thymine-DNA glycosylase | 2.27278 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 2.26027 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 2.25989 |
| DLAT | dihydrolipoamide S-acetyltransferase | 2.25689 |
| CGGBP1 | CGG triplet repeat binding protein 1 | 2.25248 |
| APTX | aprataxin | 2.24293 |
| EGR3 | early growth response 3 | 2.23167 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 2.21855 |
| SPAG4 | sperm associated antigen 4 | 2.2173 |
| REV1 | REV1, polymerase (DNA directed) | 2.21407 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 2.21108 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 2.21102 |
| ATG2B | autophagy related 2B | 2.2018 |
| CWF19L1 | CWF19-like 1, cell cycle control (S. pombe) | 2.19563 |
| INTS6 | integrator complex subunit 6 | 2.18207 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 2.1792 |
| ANKRD17 | ankyrin repeat domain 17 | 2.17158 |
| TYR | tyrosinase | 2.16686 |
| ZFY | zinc finger protein, Y-linked | 2.15933 |
| COL16A1 | collagen, type XVI, alpha 1 | 2.1593 |
| SLC16A4 | solute carrier family 16, member 4 | 2.15542 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 2.15539 |
| TYW1 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) | 2.15176 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 2.14152 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 2.14116 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 | 2.13662 |
| FER | fer (fps/fes related) tyrosine kinase | 2.13576 |
| FOXJ1 | forkhead box J1 | 2.12958 |
| CALCA | calcitonin-related polypeptide alpha | 2.12833 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 2.11793 |
| VBP1 | von Hippel-Lindau binding protein 1 | 2.11566 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 2.11524 |
| ENTPD4 | ectonucleoside triphosphate diphosphohydrolase 4 | 2.11481 |
| AACS | acetoacetyl-CoA synthetase | 2.11323 |
| HMGB3 | high mobility group box 3 | 2.10601 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 2.1051 |
| TGFBR3 | transforming growth factor, beta receptor III | 2.10465 |
| PPM1A | protein phosphatase, Mg2+/Mn2+ dependent, 1A | 2.10024 |
| GRB10 | growth factor receptor-bound protein 10 | 2.09863 |
| F8 | coagulation factor VIII, procoagulant component | 2.0944 |
| CHEK1 | checkpoint kinase 1 | 2.0926 |
| TNNI2 | troponin I type 2 (skeletal, fast) | 2.09193 |
| RASA4B | RAS p21 protein activator 4B | 2.08808 |
| SRSF2 | serine/arginine-rich splicing factor 2 | 2.0834 |
| FNBP4 | formin binding protein 4 | 2.08084 |
| TSPYL4 | TSPY-like 4 | 2.07889 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 2.07721 |
| PRKCD | protein kinase C, delta | 2.07338 |
| ADPRH | ADP-ribosylarginine hydrolase | 2.06595 |
| CCDC6 | coiled-coil domain containing 6 | 2.06381 |
| TNNC2 | troponin C type 2 (fast) | 2.06002 |
| ECD | ecdysoneless homolog (Drosophila) | 2.05962 |
| FAM3A | family with sequence similarity 3, member A | 2.05958 |
| SLK | STE20-like kinase | 2.05645 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.05197 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.04529 |
| SDHD | succinate dehydrogenase complex, subunit D, integral membrane protein | 2.03826 |
| UFM1 | ubiquitin-fold modifier 1 | 2.03744 |
| WWC3 | WWC family member 3 | 2.03073 |
| TYRP1 | tyrosinase-related protein 1 | 2.0283 |
| COL1A1 | collagen, type I, alpha 1 | 2.02707 |
| CCL21 | chemokine (C-C motif) ligand 21 | 2.02424 |
| EFCAB14 | EF-hand calcium binding domain 14 | 2.02254 |
| AFG3L2 | AFG3-like AAA ATPase 2 | 2.02203 |
| KCTD20 | potassium channel tetramerization domain containing 20 | 2.02099 |
| ARGLU1 | arginine and glutamate rich 1 | 2.01317 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 2.01072 |
| USPL1 | ubiquitin specific peptidase like 1 | 2.00837 |
| CHRDL1 | chordin-like 1 | 2.00733 |
| TMF1 | TATA element modulatory factor 1 | 2.00632 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCCB | propionyl CoA carboxylase, beta polypeptide | -5.97042 |
| MRPS2 | mitochondrial ribosomal protein S2 | -4.50818 |
| EXOSC4 | exosome component 4 | -4.04292 |
| TRAPPC3 | trafficking protein particle complex 3 | -3.92919 |
| NGRN | neugrin, neurite outgrowth associated | -3.91759 |
| TKT | transketolase | -3.74057 |
| KIF14 | kinesin family member 14 | -3.58479 |
| NELFB | negative elongation factor complex member B | -3.39134 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | -3.36239 |
| CD44 | CD44 molecule (Indian blood group) | -3.34124 |
| CANT1 | calcium activated nucleotidase 1 | -3.21226 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.0766 |
| SMC1A | structural maintenance of chromosomes 1A | -2.92702 |
| NUDC | nudC nuclear distribution protein | -2.89254 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.87159 |
| ZNF593 | zinc finger protein 593 | -2.83803 |
| SF3A2 | splicing factor 3a, subunit 2, 66kDa | -2.8245 |
| PUDP | pseudouridine 5'-phosphatase | -2.80726 |
| REXO4 | REX4, RNA exonuclease 4 homolog (S. cerevisiae) | -2.79277 |
| ACP2 | acid phosphatase 2, lysosomal | -2.78929 |
| MTX1 | metaxin 1 | -2.7335 |
| TTC38 | tetratricopeptide repeat domain 38 | -2.6834 |
| CORO1A | coronin, actin binding protein, 1A | -2.63711 |
| SURF2 | surfeit 2 | -2.6313 |
| PRSS21 | protease, serine, 21 (testisin) | -2.60242 |
| TSPAN4 | tetraspanin 4 | -2.60006 |
| CLPP | caseinolytic mitochondrial matrix peptidase proteolytic subunit | -2.59016 |
| MRPS15 | mitochondrial ribosomal protein S15 | -2.5754 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -2.57381 |
| NKIRAS2 | NFKB inhibitor interacting Ras-like 2 | -2.57169 |
| PGAP3 | post-GPI attachment to proteins 3 | -2.56059 |
| CCL5 | chemokine (C-C motif) ligand 5 | -2.55627 |
| PUF60 | poly-U binding splicing factor 60KDa | -2.54729 |
| FBXO7 | F-box protein 7 | -2.53958 |
| YARS1 | tyrosyl-tRNA synthetase 1 | -2.53493 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.52398 |
| PEX26 | peroxisomal biogenesis factor 26 | -2.48466 |
| BYSL | bystin-like | -2.47982 |
| MCAT | malonyl CoA:ACP acyltransferase (mitochondrial) | -2.44873 |
| RBM34 | RNA binding motif protein 34 | -2.44784 |
| MMP10 | matrix metallopeptidase 10 | -2.40546 |
| CD247 | CD247 molecule | -2.39307 |
| DPYS | dihydropyrimidinase | -2.38683 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -2.38683 |
| BID | BH3 interacting domain death agonist | -2.37992 |
| PAEP | progestagen-associated endometrial protein | -2.37461 |
| LOC124905557 | eukaryotic translation initiation factor 1A, X-chromosomal | -2.36696 |
| ZNF16 | zinc finger protein 16 | -2.36635 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -2.36558 |
| SORBS3 | sorbin and SH3 domain containing 3 | -2.35814 |
| FAAP100 | FA core complex associated protein 100 | -2.34663 |
| MEA1 | male-enhanced antigen 1 | -2.34218 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -2.32593 |
| FOXM1 | forkhead box M1 | -2.32026 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -2.3147 |
| ZNF580 | zinc finger protein 580 | -2.31132 |
| MED15 | mediator complex subunit 15 | -2.29912 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.29826 |
| HBG1 | hemoglobin, gamma A | -2.29678 |
| MRM3 | mitochondrial rRNA methyltransferase 3 | -2.29256 |
| CD53 | CD53 molecule | -2.28764 |
| TIMCC | TIM double twin CX3C motif chaperone | -2.275 |
| WBP2 | WW domain binding protein 2 | -2.27165 |
| CERS2 | ceramide synthase 2 | -2.25953 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -2.24066 |
| TNIP1 | TNFAIP3 interacting protein 1 | -2.23947 |
| ERP29 | endoplasmic reticulum protein 29 | -2.23319 |
| RABEPK | Rab9 effector protein with kelch motifs | -2.22539 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -2.21812 |
| ORM1 | orosomucoid 1 | -2.21395 |
| ARHGAP8 | Rho GTPase activating protein 8 | -2.21123 |
| DEXI | Dexi homolog (mouse) | -2.20617 |
| GPR65 | G protein-coupled receptor 65 | -2.19381 |
| EIF2D | eukaryotic translation initiation factor 2D | -2.17818 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -2.17772 |
| SERPINF2 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | -2.17769 |
| MAN1B1 | mannosidase, alpha, class 1B, member 1 | -2.17212 |
| FADD | Fas (TNFRSF6)-associated via death domain | -2.16477 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.16388 |
| WDR18 | WD repeat domain 18 | -2.1576 |
| DMAC2 | distal membrane arm assembly component 2 | -2.15731 |
| KIFBP | kinesin family binding protein | -2.15658 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -2.15621 |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | -2.15535 |
| MCM5 | minichromosome maintenance complex component 5 | -2.15512 |
| SF3A3 | splicing factor 3a, subunit 3, 60kDa | -2.15112 |
| YJU2 | YJU2 splicing factor homolog | -2.14854 |
| MRPS18A | mitochondrial ribosomal protein S18A | -2.14483 |
| ORM2 | orosomucoid 2 | -2.14356 |
| HABP2 | hyaluronan binding protein 2 | -2.13727 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -2.13538 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | -2.12472 |
| EIF2B2 | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | -2.11304 |
| IL18RAP | interleukin 18 receptor accessory protein | -2.11205 |
| TACO1 | translational activator of mitochondrially encoded cytochrome c oxidase I | -2.11174 |
| ENTR1 | endosome associated trafficking regulator 1 | -2.10899 |
| TMEM184B | transmembrane protein 184B | -2.10858 |
| RCC1 | regulator of chromosome condensation 1 | -2.10635 |
| ZNF629 | zinc finger protein 629 | -2.10597 |
| KLRC4-KLRK1 | KLRC4-KLRK1 readthrough | -2.10509 |
| ADSL | adenylosuccinate lyase | -2.10347 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | -2.10293 |
| SPECC1L | sperm antigen with calponin homology and coiled-coil domains 1-like | -2.10055 |
| GCAT | glycine C-acetyltransferase | -2.08646 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | -2.08426 |
| HOMER3 | homer scaffolding protein 3 | -2.08216 |
| CNPY3 | canopy FGF signaling regulator 3 | -2.08059 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D | -2.07935 |
| GNLY | granulysin | -2.07929 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -2.07625 |
| ZNF768 | zinc finger protein 768 | -2.07395 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | -2.07276 |
| KDM5C | lysine (K)-specific demethylase 5C | -2.0703 |
| SMYD5 | SMYD family member 5 | -2.0647 |
| AHSP | alpha hemoglobin stabilizing protein | -2.06385 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | -2.05999 |
| PTPRC | protein tyrosine phosphatase, receptor type, C | -2.05772 |
| UFD1 | ubiquitin recognition factor in ER associated degradation 1 | -2.05573 |
| UGT2B4 | UDP glucuronosyltransferase 2 family, polypeptide B4 | -2.05151 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | -2.04995 |
| ZNF696 | zinc finger protein 696 | -2.04848 |
| ARID5A | AT rich interactive domain 5A (MRF1-like) | -2.04119 |
| TENT4A | terminal nucleotidyltransferase 4A | -2.0362 |
| HDAC3 | histone deacetylase 3 | -2.03462 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | -2.03415 |
| G6PC1 | glucose-6-phosphatase catalytic subunit 1 | -2.02798 |
| STXBP2 | syntaxin binding protein 2 | -2.02347 |
| ATF5 | activating transcription factor 5 | -2.01869 |
| RANGAP1 | Ran GTPase activating protein 1 | -2.01629 |
| IGSF6 | immunoglobulin superfamily, member 6 | -2.01484 |
| NAA60 | N(alpha)-acetyltransferase 60, NatF catalytic subunit | -2.01472 |
| ATXN10 | ataxin 10 | -2.01438 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | -2.01363 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -2.012 |
| IL2RB | interleukin 2 receptor, beta | -2.00053 |
