CRCGN015_MCF10A_48H:A03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN015_MCF10A_48H:A03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.06312
CCNA1 cyclin A1 3.39987
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 3.01982
PSRC1 proline/serine-rich coiled-coil 1 2.84303
LORICRIN loricrin cornified envelope precursor protein 2.52133
MOSPD1 motile sperm domain containing 1 2.46514
RTL8A retrotransposon Gag like 8A 2.44149
PPOX protoporphyrinogen oxidase 2.37969
TMEM45A transmembrane protein 45A 2.36507
MTX2 metaxin 2 2.36214
FLG filaggrin 2.34165
SAE1 SUMO1 activating enzyme subunit 1 2.31593
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.30716
TUBA4B tubulin, alpha 4b 2.28626
NHEJ1 nonhomologous end-joining factor 1 2.23996
LCE2B late cornified envelope 2B 2.23739
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 2.23581
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.20307
CFAP45 cilia and flagella associated protein 45 2.11683
CDSN corneodesmosin 2.08591
IFT57 intraflagellar transport 57 2.08498
ZSCAN16 zinc finger and SCAN domain containing 16 2.08396
EFNA4 ephrin-A4 2.07976
ZNF239 zinc finger protein 239 2.0666
PARP16 poly (ADP-ribose) polymerase family, member 16 2.06467
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 2.0607
RAB17 RAB17, member RAS oncogene family 2.05899
SMAP1 small ArfGAP 1 2.04991
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.04894
KRT2 keratin 2, type II 2.04729
SMIM40 small integral membrane protein 40 2.03636
PANK2 pantothenate kinase 2 2.024
TTC23 tetratricopeptide repeat domain 23 2.02104
DTD1 D-tyrosyl-tRNA deacylase 1 2.01928
GMCL1 germ cell-less, spermatogenesis associated 1 2.00827
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 2.007
DSG1 desmoglein 1 2.00261

decreased expression

Symbol Name Standardized Value
DUSP6 dual specificity phosphatase 6 -6.09918
UFM1 ubiquitin-fold modifier 1 -5.47005
CCNB1 cyclin B1 -5.00482
S100A8 S100 calcium binding protein A8 -4.75963
EIF5 eukaryotic translation initiation factor 5 -4.55721
STXBP2 syntaxin binding protein 2 -3.60295
OAT ornithine aminotransferase -3.58278
SYPL1 synaptophysin-like 1 -3.41354
RB1 retinoblastoma 1 -3.11426
DUSP3 dual specificity phosphatase 3 -3.07563
HIPK3 homeodomain interacting protein kinase 3 -2.92843
CTSB cathepsin B -2.91046
ZMYM5 zinc finger, MYM-type 5 -2.67562
GRB2 growth factor receptor-bound protein 2 -2.55771
CERT1 ceramide transporter 1 -2.52905
BAG5 BCL2-associated athanogene 5 -2.48216
SAP18 Sin3A-associated protein, 18kDa -2.47942
VAT1 vesicle amine transport 1 -2.46109
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.42593
RFC3 replication factor C (activator 1) 3, 38kDa -2.41578
ZEB2 zinc finger E-box binding homeobox 2 -2.41242
KLC1 kinesin light chain 1 -2.40395
ELOF1 elongation factor 1 homolog (S. cerevisiae) -2.37153
LNPEP leucyl/cystinyl aminopeptidase -2.35503
RSRC1 arginine/serine-rich coiled-coil 1 -2.3504
TRAPPC13 trafficking protein particle complex 13 -2.33666
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -2.32355
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -2.31921
RCOR1 REST corepressor 1 -2.31144
FAM169A family with sequence similarity 169, member A -2.28701
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -2.27955
GPHN gephyrin -2.25891
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.25499
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.23914
PUF60 poly-U binding splicing factor 60KDa -2.21299
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.20439
XPO7 exportin 7 -2.18314
UBE2W ubiquitin-conjugating enzyme E2W (putative) -2.17929
LOC102724594 splicing factor U2AF 35 kDa subunit -2.177
DHFR dihydrofolate reductase -2.15763
TRIM25 tripartite motif containing 25 -2.15284
CANT1 calcium activated nucleotidase 1 -2.15261
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.14482
IPO8 importin 8 -2.14228
MED4 mediator complex subunit 4 -2.14022
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -2.13757
GPALPP1 GPALPP motifs containing 1 -2.12898
TPM3 tropomyosin 3 -2.12264
MTMR6 myotubularin related protein 6 -2.11261
DMAC2L distal membrane arm assembly component 2 like -2.09368
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -2.06
CYTH3 cytohesin 3 -2.05732
COG5 component of oligomeric golgi complex 5 -2.0491
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -2.04717
PALM2AKAP2 PALM2 and AKAP2 fusion -2.04405
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.03987
MRPS31 mitochondrial ribosomal protein S31 -2.03409
SERINC5 serine incorporator 5 -2.02325
MSH3 mutS homolog 3 -2.01457
TNIP1 TNFAIP3 interacting protein 1 -2.01374
TGFBR1 transforming growth factor, beta receptor 1 -2.01166
RHOH ras homolog family member H -2.01133
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -2.00774