| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 96.45 um perturbation at 48 h in MCF10A (Carcinogenome) |
| Similar Terms | |
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138 genes differentially expressed following the CRCGN015_MCF10A_48H:A13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| WIF1 | WNT inhibitory factor 1 | 5.53345 |
| STK25 | serine/threonine kinase 25 | 5.45064 |
| KIF5C | kinesin family member 5C | 5.10616 |
| CHMP6 | charged multivesicular body protein 6 | 4.2332 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 4.0832 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 4.00348 |
| TXNRD1 | thioredoxin reductase 1 | 3.20718 |
| IFRD1 | interferon-related developmental regulator 1 | 3.15567 |
| GLRX | glutaredoxin (thioltransferase) | 2.95429 |
| KLHL21 | kelch-like family member 21 | 2.94233 |
| SQSTM1 | sequestosome 1 | 2.84915 |
| RBM28 | RNA binding motif protein 28 | 2.7995 |
| HDLBP | high density lipoprotein binding protein | 2.77687 |
| HMOX1 | heme oxygenase 1 | 2.69286 |
| STC2 | stanniocalcin 2 | 2.66498 |
| NAV3 | neuron navigator 3 | 2.65665 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | 2.5852 |
| NBAS | neuroblastoma amplified sequence | 2.57708 |
| USP20 | ubiquitin specific peptidase 20 | 2.53873 |
| FAAP100 | FA core complex associated protein 100 | 2.53867 |
| CCNA1 | cyclin A1 | 2.53077 |
| SH3GLB2 | SH3-domain GRB2-like endophilin B2 | 2.5247 |
| STAP2 | signal transducing adaptor family member 2 | 2.52354 |
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | 2.51706 |
| ASB6 | ankyrin repeat and SOCS box containing 6 | 2.48921 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | 2.39447 |
| FOXK2 | forkhead box K2 | 2.39303 |
| CRCT1 | cysteine-rich C-terminal 1 | 2.35037 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 2.32359 |
| JMJD7 | jumonji domain containing 7 | 2.30891 |
| SPHK1 | sphingosine kinase 1 | 2.3035 |
| FBXO2 | F-box protein 2 | 2.28688 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 2.28368 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 2.27029 |
| CNPPD1 | cyclin Pas1/PHO80 domain containing 1 | 2.26358 |
| KRT16 | keratin 16, type I | 2.25785 |
| ANKRD27 | ankyrin repeat domain 27 (VPS9 domain) | 2.25666 |
| ADGRD2 | adhesion G protein-coupled receptor D2 | 2.25353 |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 2.2332 |
| SIL1 | SIL1 nucleotide exchange factor | 2.23207 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | 2.1972 |
| SIRT1 | sirtuin 1 | 2.19306 |
| GSTT1 | glutathione S-transferase theta 1 | 2.18792 |
| MACF1 | microtubule-actin crosslinking factor 1 | 2.18407 |
| LGALSL | lectin, galactoside-binding-like | 2.17385 |
| TALDO1 | transaldolase 1 | 2.172 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | 2.16596 |
| ATG4B | autophagy related 4B, cysteine peptidase | 2.14716 |
| CLUH | clustered mitochondria (cluA/CLU1) homolog | 2.13977 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 2.13531 |
| DUSP5 | dual specificity phosphatase 5 | 2.13128 |
| CHEK2 | checkpoint kinase 2 | 2.11845 |
| PLBD1 | phospholipase B domain containing 1 | 2.11622 |
| GDF2 | growth differentiation factor 2 | 2.08929 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 2.08202 |
| FMO1 | flavin containing monooxygenase 1 | 2.07116 |
| DIXDC1 | DIX domain containing 1 | 2.06518 |
| CYP2W1 | cytochrome P450, family 2, subfamily W, polypeptide 1 | 2.0577 |
| SLC36A1 | solute carrier family 36 (proton/amino acid symporter), member 1 | 2.04771 |
| ACVR1 | activin A receptor, type I | 2.04387 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 2.04066 |
| PLD2 | phospholipase D2 | 2.03581 |
| RASAL2 | RAS protein activator like 2 | 2.02891 |
| PDIA2 | protein disulfide isomerase family A, member 2 | 2.02681 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 2.02377 |
| TMEM40 | transmembrane protein 40 | 2.0237 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | 2.02215 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 2.01263 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 2.01259 |
| ZNF516 | zinc finger protein 516 | 2.00637 |
| LPAR1 | lysophosphatidic acid receptor 1 | 2.00443 |
| KRT31 | keratin 31, type I | 2.00392 |
| GLRB | glycine receptor, beta | 2.00133 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | 2.0011 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB1 | cyclin B1 | -5.7969 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | -5.01152 |
| SLC35F2 | solute carrier family 35, member F2 | -4.79913 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.89279 |
| ANXA3 | annexin A3 | -3.43429 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | -3.40373 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -3.28136 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -3.21516 |
| SNRPE | small nuclear ribonucleoprotein polypeptide E | -3.06374 |
| RBM34 | RNA binding motif protein 34 | -3.03998 |
| NLRP4 | NLR family, pyrin domain containing 4 | -2.88594 |
| RFC4 | replication factor C (activator 1) 4, 37kDa | -2.87057 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.86246 |
| RAB4A | RAB4A, member RAS oncogene family | -2.76617 |
| TP53RK | TP53 regulating kinase | -2.64363 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -2.59985 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.59674 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | -2.56797 |
| PLK1 | polo-like kinase 1 | -2.52527 |
| LEMD3 | LEM domain containing 3 | -2.51542 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | -2.51486 |
| ATL2 | atlastin GTPase 2 | -2.5083 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -2.46154 |
| ANKRD10 | ankyrin repeat domain 10 | -2.42164 |
| GRAMD1B | GRAM domain containing 1B | -2.39752 |
| KIF20A | kinesin family member 20A | -2.39023 |
| FOXJ2 | forkhead box J2 | -2.37512 |
| NUP62CL | nucleoporin 62kDa C-terminal like | -2.36895 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | -2.35588 |
| MNX1 | motor neuron and pancreas homeobox 1 | -2.3312 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | -2.32348 |
| SRP9 | signal recognition particle 9kDa | -2.30266 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -2.25253 |
| NUP37 | nucleoporin 37kDa | -2.25136 |
| GGPS1 | geranylgeranyl diphosphate synthase 1 | -2.24368 |
| PRKCB | protein kinase C, beta | -2.24015 |
| APEX1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | -2.22341 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -2.20846 |
| AIDA | axin interactor, dorsalization associated | -2.20023 |
| TM2D3 | TM2 domain containing 3 | -2.19173 |
| MCTS1 | malignant T cell amplified sequence 1 | -2.1603 |
| H2AZ1 | H2A.Z variant histone 1 | -2.13865 |
| LIMD1 | LIM domains containing 1 | -2.13338 |
| HADH | hydroxyacyl-CoA dehydrogenase | -2.12191 |
| DMBT1 | deleted in malignant brain tumors 1 | -2.1131 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | -2.10767 |
| PSME3IP1 | proteasome activator subunit 3 interacting protein 1 | -2.09594 |
| RPL26L1 | ribosomal protein L26-like 1 | -2.08955 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.08158 |
| AK6 | adenylate kinase 6 | -2.07938 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -2.07867 |
| GNPAT | glyceronephosphate O-acyltransferase | -2.07563 |
| COX7C | cytochrome c oxidase subunit VIIc | -2.07025 |
| OIP5 | Opa interacting protein 5 | -2.06881 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -2.06573 |
| ARHGAP15 | Rho GTPase activating protein 15 | -2.06222 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -2.05539 |
| MRPL11 | mitochondrial ribosomal protein L11 | -2.05306 |
| DCLRE1B | DNA cross-link repair 1B | -2.05204 |
| SULT1B1 | sulfotransferase family, cytosolic, 1B, member 1 | -2.0329 |
| BFAR | bifunctional apoptosis regulator | -2.03196 |
| IRF8 | interferon regulatory factor 8 | -2.01553 |
| F8 | coagulation factor VIII, procoagulant component | -2.01118 |
| LOC107986346 | mitochondrial import receptor subunit TOM7 homolog | -2.00065 |
