CRCGN015_MCF10A_48H:A14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 32.15 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN015_MCF10A_48H:A14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 3.62887
WIF1 WNT inhibitory factor 1 3.59924
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.4331
SNX11 sorting nexin 11 3.31514
TXNRD1 thioredoxin reductase 1 2.86203
HBA1 hemoglobin, alpha 1 2.75948
CDPF1 cysteine-rich, DPF motif domain containing 1 2.73418
BHMT2 betaine--homocysteine S-methyltransferase 2 2.67006
GLRX glutaredoxin (thioltransferase) 2.56781
STIMATE STIM activating enhancer 2.53747
UPP1 uridine phosphorylase 1 2.51744
SQSTM1 sequestosome 1 2.4915
CALB1 calbindin 1, 28kDa 2.3637
GRWD1 glutamate-rich WD repeat containing 1 2.3572
MATN2 matrilin 2 2.34284
PUDP pseudouridine 5'-phosphatase 2.25487
FAT1 FAT atypical cadherin 1 2.21076
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.17582
LYPD3 LY6/PLAUR domain containing 3 2.17249
BCAR3 breast cancer anti-estrogen resistance 3 2.15362
ZNF593 zinc finger protein 593 2.14424
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.13988
KLHL21 kelch-like family member 21 2.13562
DYSF dysferlin 2.10878
CYB5R1 cytochrome b5 reductase 1 2.10172
FSD1 fibronectin type III and SPRY domain containing 1 2.10013
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.02692
MDFI MyoD family inhibitor 2.0172
AEN apoptosis enhancing nuclease 2.01002
IL4R interleukin 4 receptor 2.00753
SREK1IP1 SREK1-interacting protein 1 2.00038

decreased expression

Symbol Name Standardized Value
MCUR1 mitochondrial calcium uniporter regulator 1 -4.48305
NPDC1 neural proliferation, differentiation and control, 1 -4.19528
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.95377
LDHB lactate dehydrogenase B -3.49001
NKX2-2 NK2 homeobox 2 -2.68842
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.59343
MELK maternal embryonic leucine zipper kinase -2.56872
ANXA3 annexin A3 -2.55402
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.4616
DDIT4 DNA-damage-inducible transcript 4 -2.45548
TROAP trophinin associated protein -2.42223
GNAS GNAS complex locus -2.41971
TTC13 tetratricopeptide repeat domain 13 -2.3272
ZNF184 zinc finger protein 184 -2.30174
JMJD6 jumonji domain containing 6 -2.26568
FOXM1 forkhead box M1 -2.24656
PRKCB protein kinase C, beta -2.24515
RANBP9 RAN binding protein 9 -2.18182
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -2.15609
CD69 CD69 molecule -2.11013
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 -2.08794
MDC1 mediator of DNA-damage checkpoint 1 -2.02102
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -2.01258