CRCGN015_MCF10A_48H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole 10.72 um perturbation at 48 h in MCF10A (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN015_MCF10A_48H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HYOU1 hypoxia up-regulated 1 4.82938
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.64941
CCNA1 cyclin A1 3.64155
PAPPA pregnancy-associated plasma protein A, pappalysin 1 3.06374
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.73305
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.72788
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.50274
MYLK3 myosin light chain kinase 3 2.47238
NMRK2 nicotinamide riboside kinase 2 2.46393
TGM3 transglutaminase 3 2.37347
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.37033
CAV3 caveolin 3 2.34067
FPGS folylpolyglutamate synthase 2.33933
ACTN2 actinin, alpha 2 2.30002
PRR16 proline rich 16 2.2689
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.26575
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.24804
DUSP13A dual specificity phosphatase 13A 2.24664
MYOM1 myomesin 1 2.20063
LCN1 lipocalin 1 2.17894
MNMIP1 manchette microtubule inner protein 1 2.17061
IFNB1 interferon, beta 1, fibroblast 2.15671
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.1566
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.14563
ENO3 enolase 3 (beta, muscle) 2.12169
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.10332
PDIA5 protein disulfide isomerase family A, member 5 2.086
KRT3 keratin 3, type II 2.07818
CES1 carboxylesterase 1 2.06784
TREH trehalase (brush-border membrane glycoprotein) 2.06222
SKA1 spindle and kinetochore associated complex subunit 1 2.05959
SORBS1 sorbin and SH3 domain containing 1 2.04328
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.03817
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.03505
PAX9 paired box 9 2.02046
MOK MOK protein kinase 2.01757
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.00962
IL17B interleukin 17B 2.00728
SYNPO2L synaptopodin 2-like 2.00548
PRR15L proline rich 15-like 2.00203

decreased expression

Symbol Name Standardized Value
SNX7 sorting nexin 7 -5.71023
IGFBP7 insulin-like growth factor binding protein 7 -4.61888
ANXA3 annexin A3 -4.55305
MT2A metallothionein 2A -3.66821
REEP5 receptor accessory protein 5 -3.32297
VIM vimentin -3.14515
LDHB lactate dehydrogenase B -2.78805
IFI27 interferon, alpha-inducible protein 27 -2.63427
GTPBP8 GTP-binding protein 8 (putative) -2.33994
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.33367
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.31328
ATP9A ATPase, class II, type 9A -2.29354
KDM3A lysine (K)-specific demethylase 3A -2.26973
MKNK1 MAP kinase interacting serine/threonine kinase 1 -2.19812
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.16972
MELK maternal embryonic leucine zipper kinase -2.14884
BAG3 BCL2-associated athanogene 3 -2.08648
EIF2D eukaryotic translation initiation factor 2D -2.06866
SLC35A5 solute carrier family 35, member A5 -2.04831
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.0273
FZD6 frizzled class receptor 6 -2.02721
FSTL1 follistatin-like 1 -2.01987
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.01202
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 -2.00325